Shahrad qualified in medicine from St Bartholomew’s Medical College (Barts), London University. He trained in diabetes and endocrinology at Barts, the Hammersmith hospital, and Bristol Royal Infirmary. He obtained his PhD as a Wellcome Trust research fellow in neuroendocrinology at Imperial College, London University. His research focused on the hypothalamic orexin peptide neurons, which are important in regulation of sleep and wakefulness, appetite, and energy expenditure. This was followed by training in sleep research at Stanford University as a Howard Hughes Medical Institute research associate. His work with the Wisconsin Sleep Cohort Study showed, for the first time, a major link between sleep and obesity, and sleep and metabolic hormones, in a large population. He returned to the UK in 2003 as Lecturer in medicine at Bristol University.
Shahrad has had several national and international awards for his research and is a reviewer for several journals and funding bodies. His research ranges from basic laboratory to population research and service delivery reorganization.
Research interest spans all age groups and covers clinical and scientific areas that are important to healthy ageing and chronic disorders. These include sleep, metabolism, and immunity. My research into the sleep-endocrine-metabolic interface uses multiple approaches: basic laboratory, human laboratory, and population studies. Additionally, I have a major interest in pharmacotherapy for obesity, metabolic disorders and sleep disorders, and bariatric surgery and its metabolic consequences.
Major research areas – physiology and pharmacology of: Sleep, metabolism, neuroendocrinology and ageing; Sleep and its interaction with metabolism; Obesity and metabolism; Nutrition and health; Metabolic surgery.
Clinical research interests are in diabetes service development and evaluation.
Lead Clinician (Honorary Consultant Physician) and Research LeadWeight Management Services, Heart of England NHS Foundation Trust.
Co-Director, Heartlands Biomedical Research Centre (HBMRC)
Clinical Research Network CLRN: priority lead for the Birmingham and Black Country BBC CLRN for metabolism, endocrinology and obesity and sit on the UK national committee.
National CLRN Specialty Board: member of the national CLRN board for metabolism, endocrinology and obesity. I assess protocols for national studies and assess potential for study implementation.
Jose B, Ali A, Begum S, Banerjee D, Taheri S. Obstructive sleep apnoea as a cause of headache presenting to the emergency department. QJM. 2010 Dec 7. [Epub ahead of print] PubMed PMID: 21138944.
Taheri S, Mignot E. Sleep well and stay slim: dream or reality? Ann Intern Med. 2010 Oct 5;153(7):475-6. PubMed PMID: 20921547.
Thomas GN, Jiang CQ, Taheri S, Xiao ZH, Tomlinson B, Cheung BM, Lam TH, Barnett AH, Cheng KK. A systematic review of lifestyle modification and glucose intolerance in the prevention of type 2 diabetes. Curr Diabetes Rev. 2010 Nov;6(6):378-87. PubMed PMID: 20879973.
Deville-Almond J, Tahrani AA, Grant J, Gray M, Thomas GN, Taheri S. Awareness of obesity and diabetes: a survey of a subset of british male drivers. Am J Mens Health. 2011 Jan;5(1):30-7. Epub 2010 Apr 21. PubMed PMID: 20413385.
Lam KB, Jiang CQ, Thomas GN, Arora T, Zhang WS, Taheri S, Adab P, Lam TH Cheng KK. Napping is associated with increased risk of type 2 diabetes: the Guangzhou Biobank Cohort Study. Sleep. 2010 Mar 1;33(3):402-7. PubMed PMID: 20337199; PubMed Central PMCID: PMC2831435.
Honda M, Eriksson KS, Zhang S, Tanaka S, Lin L, Salehi A, Hesla PE, Maehlen J, Gaus SE, Yanagisawa M, Sakurai T, Taheri S, Tsuchiya K, Honda Y, Mignot E. (2009) IGFBP3 colocalizes with and regulates hypocretin (orexin). PLoS One. 4(1):e4254. Epub 2009 Jan 22.
Taheri S, Thomas GN. (2008) Is sleep duration associated with obesity-where do U stand? Sleep Med Rev. Aug;12(4):299-302.
Taheri S, Austin D, Lin L, Nieto FJ, Young T, Mignot E. (2007) Correlates of serum C-reactive protein (CRP)--no association with sleep duration or sleep disordered breathing. Sleep. Aug 1;30(8):991-6.