Professor Prem Kumar

Professor of Physiological Science

Cardiovascular and Respiratory Sciences

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Contact details

School of Clinical and Experimental Medicine
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

About

Prem Kumar is a Professor of Physiological Science. He is also Phase 1 Lead for the MBChB programme and is the Director of Education for the College of Medical and Dental Sciences.

His research interests are in the field of chemoreception, with a particular emphasis on carotid body and pulmonary artery chemotransduction mechanisms in health and disease and in the reflex responses to hypoxia and changes in blood glucose concentrations.

Professor Kumar has served on a number of Journal Editorial Boards, including the Journal of Physiology, Respiratory Physiology & Neurobiology and the Journal of Applied Physiology. In addition, he has served on the Executive Committee of the Physiological Society, where he chaired the Meetings Committee with responsibility for organising major International Conferences and he is presently serving on the 2013 IUPS Committee. He is also a member of the International Committee of the American Physiological Society.

Professor Kumar is an enthusiastic teacher and holds key positions in the delivery and administration of undergraduate and postgraduate medical training at Birmingham as well as performing duties as an External Examiner at other UK and International Universities.

Qualifications

  • D.Phil (Oxon) 1986
  • B.Sc (Hons) Physiology (Leeds) 1982

Biography

Prem Kumar graduated (B.Sc Hons) as a Physiologist from the University of Leeds in 1982 and went on to compete a D.Phil (Ph.D) at the University of Oxford, working with Drs Bob Torrance and Piers Nye, where he became interested in understanding how the body senses and responds to changes in its blood chemical composition. He followed this with a brief postdoctoral position at the University of Reading where, under the leadership of Professor Mark Hanson, he extended his interests into an understanding of the development of chemoreception during fetal and neonatal life. This led to a Lectureship appointment at the University of Birmingham in 1990, where he moved via a Senior Lectureship to the Readership position he now holds. A 5-year Lister Institute Fellowship was awarded to him between 1995-2000 and during this period he worked to develop an in vitro carotid body preparation that has allowed him to examine transduction processes that would not have been possible to study in vivo. He has been invited to speak at a number of national and international meetings, including the Nobel Conference on Oxygen Biology at the Karolinska Institute in Stockholm, as well as at major meetings in Brazil, China, Japan and North America.

He is proud to be a physiologist and has worked in a number of key positions within the Physiological Society of UK and Ireland to help promote the subject. In addition to serving as a Council Member of the Society, he has also held the Chair position of the Meetings Committee, where he took a lead role in the development of the Society’s strategy for Conference organisation and delivery and in the organising of a number of International Meetings and has been a member of the Society’s Executive Committee.  

He has worked for a number of Journals in Editorial positions – holding roles as Reviewing Editor and Deputy Editor-in Chief for The Journal of Physiology as well as Editorial positions for Respiratory Physiology and Neurobiology and International Consulting Editor for the Journal of Applied Physiology.

He holds key roles in the administration of Education in the College of Medical and Dental Sciences and in the 5-year medical (MBChB) course at the University of Birmingham, working with colleagues to ensure its appropriate delivery and assessment.

Teaching

  • Module Lead: Introduction to Respiratory Medicine – Yr 1 MBChB
  • Module Lead: Integrated Problems – Yrs 1-2 MBChB
  • Module Lead: Cardiorespiratory Sysytem II: 3rd Year B.Med. Sci
  • SGT tutor – B.Med.Sci , MBChB, BDS

Postgraduate supervision

Prem has successfully supervised a number of Ph.D students and is interested in supervising further doctoral research students in the following broad area:

Hypoxia sensing and cardiorespiratory control in health and disease – to include a range of approaches from single cell to whole animal; from electrophysiology to reflex measurement.

Full and appropriate training will be given.

If you are interesting in studying this subject area, please contact Prem on the contact details above, or for any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk or call +44 (0)121 414 5005.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.   

Research

Dr Prem Kumar’s research interests are in the area of cardiorespiratory physiology with a particular emphasis on chemotransduction mechanisms and the postnatal development of chemoreceptor sensitivity. The general approach he has adopted in the laboratory is to utilise a number of models ranging from in vivo to molecular-based from which hypotheses can be tested through various levels of organisation. 

Major research presently undertaken involves:

  1. Glucose sensing by peripheral chemoreceptors – are these receptors more than 'just' oxygen sensors? Could they play a role in sensing systemic metabolism and hence act to match ventilation to metabolism? Might this function be impaired in certain disease states eg diabetes, heart failure, COPD?
  2. Role of AMPK in chemoreception (collaboration with colleagues in Edinburgh, Leeds and Dundee). Could O2 sensing in the carotid body be mediated via a fall in the AMP/ATP ratio as detected by the AMP-activated protein kinase (AMPK)? Could this be a particular sensitive detection of cellular metabolism in O2-sensitive tissue, mediated perhaps by specific isoforms of the catalytic subunits of AMPK?
  3. Role of ATP in mediating vasomotion. Could vasomotion – or its lack – be implicated in the aetiology of pre-eclampsia? Might ATP release from blood or cells of the umbilicus / placenta be involved in its control?
  4. Catecholaminergic mediation of exercise hyperpnea. Ventilation increase in hypoxia without change in blood gas tensions. This suggests that either the chemical sensing of blood is not involved or that the carotid body sensitivity to other stimuli acts to augment discharge during exercise. This study is also examining a possible link between catecholamines and ventilatory impairment in chronic heart failure.
  5. Apnea and the control of breathing. The intermittent hypoxia of recurrent sleep apnoea appears to be able to induce a form of long-term facilitation in carotid body function (perhaps via ROS) and this augmented chemodischarge could underlie the increased sympathetic drive that leads to hypertension in these patients. This study utilises models of intermittent hypoxia.

Other activities

1998 - 2006   Editor, Journal of Physiology

1999 - 2001   Ethical Editor, Journal of Physiology

2001 - 2003   Senior Editor, Journal of Physiology

2003 - 2006   Deputy Editor-in-Chief, The Journal of Physiology

2003 - 2011   Editor, Respiratory Physiology and Neurobiology

2008 - 2011   International Consulting Editor, Journal of Applied Physiology

2005 - 2013   IUPS UK Executive planning Committee

2006 - 2010   Chair, Meeting Committee – The Physiological Society

2006 - 2010   Member of Executive Committee  – The Physiological Society

2006 - 2007   Council Member – The Physiological Society

Publications

Hauton D, Holmes A, Ziff O, Kumar P. (2013) The impact of acute and chronic catecholamines on respiratory responses to hypoxic stress in the rat. Pflugers Arch. 465: 209-19

Kumar P, Prabhakar NR. (2012) Peripheral chemoreceptors: function and plasticity of the carotid body Compr Physiol.  2(1):141-219

Holmes AP, Hauton D, Kumar P. (2012) The interaction between low glucose and hypoxia in the in vitro, rat carotid body Adv Exp Med Biol. 758:123-7.

Kumar P. (2012) The carotid body in cardiovascular disease: more chicken and egg than horse and cart? J Physiol. 590: 4123

Kumar P, Peers C. (2012) The emergence of carbon monoxide (CO) and hydrogen sulphide (H2S) as biologically active gases. Respir Physiol Neurobiol. 184:115-6.

Griffin HS, Pugh K, Kumar P, Balanos GM. (2012). Long-term facilitation of ventilation following acute continuous hypoxia in awake humans during sustained hypercapnia. J Physiol. 590:5151-65.

Lykidis CK, Kumar P, Vianna LC, White MJ, Balanos GM. (2010) A respiratory response to the activation of the muscle metaboreflex during concurrent hypercapnia in man. Exp Physiol. 95: 194-201

Kumar P. (2009) Systemic effects resulting from carotid body stimulation. Adv Exp Med Biol. 648: 223-33.

Wyatt CN, Mustard KJ, Pearson SA, Dallas ML, Atkinson L, Kumar P, Peers C, Hardie DG, Evans AM. (2007) AMP-activated protein kinase mediates carotid body excitation by hypoxia. J Biol Chem, 282: 8092-8098

Kumar, P. & Bin Jaliah, I. (2007) Adequate stimuli of the carotid body: more than an oxygen sensor? Respiratory Physiology & Neurobiology, 157, 12-21

Kumar, P. (2007) Sensing hypoxia in the carotid body: from stimulus to response. In: Essays in Biochemistry Oxygen Sensing And Hypoxia-Induced Responses. Edited by C. Peers. Portland Press 43-58

Meng, F., To, W., Kirkman-Brown,J., Kumar,P. & Gu, Y. (2007) Calcium oscillation induced by ATP in human umbilical cord smooth muscle cells. J Cell Physiol

Bin Jaliah, I., Maskell, P.D & Kumar, P. (2005) – Carbon dioxide sensitivity during hypoglycaemia-induced, elevated metabolism in the anaesthetized rat. Journal of Physiology, 563.3, 883-893, 563.3, 883-893

Evans, A.M., Mustard, K.J.W., Wyatt, C.N., Peers, C., Dipp, M., Kumar, P., Kinnear, N.P., Hardie, D.G. (2005). Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells? The Journal of Biological Chemistry, 280, 41504-4151

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