Ana Maria Gonzalez received her BSc degree in Biology from Universidad de Los Andes in Bogota, Colombia in 1981. After working for 3 years as a research fellow in Hospital Ramon y Cajal in Madrid, Spain, she moved to the US where she worked in the Laboratories for Neuroendocrinology at the Salk and Scripps Institutes in La Jolla, California. In 1991 she obtained her PhD from Universidad Autonoma de Madrid. She went back to California and in 1995 joined "Selective Genetics" - a biotechnology company in San Diego where she worked as a Senior Scientist for 6 years. In 2001 she moved to London and was appointed Senior Lecturer in the Division of Physiology, School of Biomedical Sciences at King's College London. In 2004, she joined the University of Birmingham.
Dr Ana Maria Gonzalez is a principal Investigator in the CSF Disorders Research Group (http://www.birmingham.ac.uk/research/activity/mds/domains/cardio-resp-neuro/neurotrauma/cerebrospinal-fluid-disorders/index.aspx).
She has a long standing research interest on the roles played by the growth factors and neuropeptides in the injured CNS as well as in other conditions such as intracranial idiopatic hypertension and hydrocephalus.
In collaboration with Professor Andrew Baird at the University of California, San Diego and Professors Conrad Johanson and Ed Stopa at Brown University in Providence, she has been investigating the role that novel peptide hormones may play in CNS homeostasis after trauma. A case of point is a newly recognised neuropeptide encoded by the oesophageal related gene-4 (Ecrg4). These studies clearly suggest this peptide (augurin) plays a role in CSF homeostasis.
Due to her great interest in the field of histology and microscopy and as manager of the Neucar Histology and Microscopy Core Facility she has research collaborations with various research groups across the College.
Ahmed Z, Bansal D, Tizzard K, Surey S, Esmaeili M, Douglas MR, Gonzalez AM, Berry M and Logan A (2013) Decorin blocks scarring and cystic cavitation in acute and induces scar dissolution in chronic spinal cord wounds. Neurobiol Dis 64:163-76
Chan SY, Hancox LA, Martin-Santos A, Loubiere LS, Walter MN, Gonzalez AM, Cox PM, Logan A, McCabe CJ, Franklyn JA and Kilby M (2013) MCT8 in human fetal cerebral cortex is reduced in severe intrauterine growth restriction. J Endocrinol 220(2):85-95
Johanson CE, Gonzalez AM, Miller M, Podvin S, Stopa E and Baird A (2013) Augurin in choroid plexus-cerebrospinal fluid: Implications for subependymal neurogenesis. In The Handbook of Biologically Active Peptides, 2nd edition, A. Kastin, ed., Elsevier Press, 2013
Botfield H, Gonzalez AM, Abdullah O, Skjolding AD, Berry M, McAllister JP II and Logan A (2013) Decorin prevents the development of juvenile communicating hydrocephalus. Brain 136(Pt 9):2842-58
Gonzalez AM, Podvin S, Lin SY, Miller MC, Botfield H, Leadbeater WE, Roberton A, Dang X, Knowling SE, Cardenas-Galindo E, Donahue JE, Stopa EG, Johanson CE, Coimbra R, Eliceiri BP and Baird A (2011) Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury. Fluids Barriers CNS 8(1):6
Podvin S, Gonzalez AM, Miller MC, Dang X, Botfield H, Donahue JE, Kurabi A, Boissaud-Cooke M, Rossi R, Leadbeater WE, Johanson CE, Coimbra R, Stopa EG, Eliceiri BP and Baird A (2011) Esophageal cancer related gene-4 is a choroid plexus-derived injury response gene: evidence for a biphasic response in early and late brain injury. PLoS One 6(9):e24609
Sawada R, Peterson CY, Gonzalez AM, Potenza BM, Mueller B, Coimbra R, Eliceiri BP and Baird A (2011) A phage-targeting strategy for the design of spatiotemporal drug delivery from grafted matrices. Fibrogenesis Tissue Repair 4:7
Susarla R, Gonzalez AM, Watkinson JC and Eggo MC (2011) Expression of receptors for VEGFS on normal human thyroid follicular cells and their role in follicle formation. J Cell Physiol 227(5):1992-2002
For a full list of Dr Gonzalez' publications click here.