Selected Recent Publications
"X-ray Studies of Cavern Sizes and Mixing Performance with Fluids Possessing a Yield Stress", (with TP Elson and DJ Cheesman), Chem. Eng. Sci., 41, (1986), 2555-2562 voted one of the 21 most influential papers on mixing by the AIChE’s North American Mixing Forum, 2011.
Harnby, N., Edwards, M.F. and Nienow, A.W., (Eds), "Mixing in the Process Industries", 2nd Edition (in paperback), Butterworth Heinemann, London, 1997, 414 pages.
"Hydrodynamics of Stirred Bioreactors", in "Fluid Mechanics Problems in Biotechnology", R. Pohorecki, ed., App.Mech.Rev., 51, (1998), 3-32.
"Aeration-Biotechnology", Kirk Othmer Encyclopedia of Chemical Technology, 5th Edition, Wiley, New York, on-line edition 2003.
“Blending of Miscible Liquids” (with R. K. Grenville), in “Handbook of Industrial Mixing; Science and Practice”, (Eds. E.L Paul, V.A Atiemo-Obeng and S.M. Kresta), Wiley-Interscience, N.Y., 2003, Ch. 9, pp 507-539.
”Mixing in the Fermentation and Cell Culture Industries” (with A. Amanullah and B.C. Buckland), in “Handbook of Industrial Mixing; Science and Practice”, (Eds. E.L Paul, V.A Atiemo-Obeng and S.M. Kresta), Wiley-Interscience, N.Y., 2003, Ch. 18, pp 1071-1157.
“A Vessel for Mixing a Cell Lysate”, (with A.G. Hitchcock and G.L. Riley);. European patent 1159062, 12th November 2003, 14 pages.
“Further Studies Related to the Scale-up of High Cell Density Escherichia coli Fed-batch Fermentations: the Additional Effect of a Changing Micro-environment When Using Aqueous Ammonia to Control pH”, (with H. Onyeaka and C J. Hewitt), Biotechnol. Bioeng.,84, (2003), 474 –484.
“Break-up, Coalescence and Catastrophic Phase Inversion in Turbulent Contactors”, Advances in Colloid and Interface Science, 108-109C, (2004), 95-103.
“The Versatility of Up-Pumping Hydrofoil Agitators”, (with W. Bujalski), Chem. Eng. Res. Des. (Trans. I. Chem. E, Part A), 82, (2004), 1073-1081.
“The Suspension of Microcarriers for Cell Culture with Axial Flow Impellers”, (with S. Ibrahim), Chem. Eng. Res. Des. (Trans. I. Chem. E, Part A), 82, (2004), 1082-1088.
“Intensifying Micromixing in a Semi-Batch Reactor Using a Rushton Turbine”, (with M. Assirelli, W. Bujalski, A. Eaglesham), Chem. Eng. Sci., 60, (2005), 2333-2339.
The Impact of Fluid Mechanical Stress on Corynebacterium glutamicum During Continuous Cultivation in an Agitated Bioreactor”, (with S. Chamsartra and C. J. Hewitt), Biotech. Letters, 27, (2005), 693-700.
“Reactor Engineering in Large Scale Animal Cell Culture”, Cytotechnology, 50, (2006), 9-33.
“Bubble Sizes In Agitated Solvent/Reactant Mixtures Used In Heterogeneous Catalytic Hydrogenation of 2-Butyne-1, 4-diol”, (with Binjie Hu, E Hugh Stittand Andrzej W. Pacek), Chem. Eng. Sci., 61, (2006) 6765-6774.
“A Comparison of High Cell Density Fed-Batch Fermentations Involving Both Induced and Non-Induced Recombinant Escherichia Coli Under Well-Mixed Small-Scale and Simulated Poorly-Mixed Large-Scale Conditions” (with C J. Hewitt, H Onyeaka, G Lewis and I W. Taylor), Biotechnol. Bioeng., 96, (2007), 495–505.
“Simultaneous Measurement of In-situ Bubble Size and Reaction Rates with a Heterogeneous Catalytic Hydrogenation Reaction” (with B. Hu, R.P. Fishwick, A.W. Pacek, J.M.Winterbottom, J.Wood and E.H. Stitt), Chem. Eng. Sci. 62, (2007), 5392 – 5396.
“Mixing in Bioreactors using Agitators with a High Solidity Ratio and Deep Blades”, (with M. J. H. Simmons, H. Zhu, W. Bujalski and C. J. Hewitt), Chem. Eng. Res. Des. (Trans. I. Chem. E., Part A), 85, (2007), 551-559.
“The Scale-Up of Microbial Batch and Fed-Batch Fermentation Processes”, (with C. J. Hewitt), (Eds A. L. Laskin, S. Sariaslani, G. M. Gadd), Elsevier/Academic Press, (ISBN:978-0-12-373669-7); Adv. in Applied Microbiology, 62, (2007), 105-136.
“Bubble Sizes in Agitated Water-Hydrophilic Organic Solvents for Heterogeneous Catalytic Reactions”, (with B. Hu, E. H. Stitt and A. W. Pacek), Ind. Eng. Chem. Res., 46. (2007), 4451-4458.
“Macro- and Micro-Mixing Studies in an Unbaffled Vessel Agitated by a Rushton Turbine”, (with M. Assirelli; W. Bujalski; A. Eaglesham), Chem. Eng. Sci, 63, (2008), 35– 46.
"An Extension to the Incorporation Model of Micromixing and its Use in Estimating Local Specific Energy Dissipation Rates", (with M. Assirelli, E. J. W. Wynn, W Bujalski and A. Eaglesham), Ind. Eng. Chem. Res. 47,(2008), 3460-3469.
“Mixing by Rotary Jet Heads: Indications of the Benefits of Head Rotation Under Turbulent and Transitional Flow Conditions”, (with M. Nordkvist, M. Vognsen, J. Villadsen and K. V. Gernaey), Chem. Eng. Res. Des., (Trans. I Chem Eng. Part A),. 86, (2008), 1454-1461.
“Mixing Studies in a Model Aerated Bioreactor Equipped with an Up- or a Down-Pumping 'Elephant Ear' Agitator; Power, Hold-up and Aerated Flow Field Measurements”, (with H. Zhu, W Bujalski and M. J. H. Simmons), Chem. Eng. Res. Des. (Trans. I. Chem. E., Part A) 87, (2009), 307-317.
“Use of angle resolved PIV to estimate local specific energy dissipation rates for up- and down-pumping pitched blade agitators in a stirred tank”, (with A. Gabriele and M.J.H. Simmons), Chem. Eng. Sci., 64, (2009), 126-143.
“Positron Emission Particle Tracking in a Mechanically Agitated Solid-Liquid Suspension of Coarse Particles” (withA. Guida, X. Fan, D.J. Parkerand M. Barigou), Chem. Eng. Res. Des., (Trans. I Chem Eng. Part A), 87, (2009), 421-429.
“Using Positron Emission Particle Tracking (PEPT) to Study Mixing in Stirred Vessels: Validation and Tackling Unsolved Problems in Opaque Systems”, (with M. Barigou, F. Chiti, P. Pianko-Oprych, A. Guida, L. Adams,X. Fan and D. J. Parker), J. Chem. Eng., Japan, 42, (2009), 839 -846.
“Scale-Up Considerations Based on Studies at the Bench Scale in Stirred Bioreactors”, J. Chem. Eng., Japan, 42, (2009), 789 -796.
“The Effect of Viscosity on Particle Suspension in an Aerated Stirred Vessel with Different Impellers and Bases”, (with S. Ibrahim), Chem. Eng. Comm., 197, (2010), 434 – 454.
“Stirred Tank Reactors”. In: Ullmann's Encyclopedia of Industrial Chemistry (7th Edition), Wiley-VCH Verlag GmbH & Co. Weinheim, Germany, CD and Online Posting Date: January 15, 2010; DOI: 10.1002/14356007.b04_167.pub2.
“Impeller Selection: Animal Cell Culture”. In: Encyclopedia of Industrial Biotechnology, John Wiley & Sons, Inc., Hoboken, NJ, USA, DOI: 10.1002/9780470054581.eib636 Online Posting Date: April 15, 2010; Vol. 5, pp 2959-2971.
“Scale-Up, Stirred Tank Reactors”. In: Encyclopedia of Industrial Biotechnology, John Wiley & Sons, Inc., Hoboken, NJ, USA, DOI: 10.1002/9780470054581.eib535 Online Posting Date: April 15, 2010; Vol. 7, pp 4328 – 4341.
“PEPT Measurements of Solid–Liquid Flow Field and Spatial Phase Distribution in Concentrated Monodisperse Stirred Suspensions”, (withA. Guida and M. Barigou), Chem. Eng. Sci., 65, (2010), 1905-2264;.
“Shannon Entropy for Local and Global Description of Mixing by Lagrangian Particle Tracking”, (with A. Guida and M. Barigou), Chem. Eng. Sci., 65, (2010), 2865-2883:
“The Effects of the Azimuthal Position of the Measurement Plane on the Flow Parameters Determined by PIV within a Stirred Vessel”, (with A. Guida and M. Barigou), Chem. Eng. Sci., 65, (2010), 2454-2463.
“Micromixing in Two-phase (g-l and s-l) Systems in a Stirred Vessel”, (with J. Hofinger, R. W. Sharpe, W. Bujalski, S. Bakalis, M. Assirelli and A. Eaglesham), Can. J. Chem. Eng., 89, (2011), 1029-1039.
“Using Positron Emission Particle Tracking (PEPT) to Study the Turbulent Flow in a Baffled Vessel Agitated by a Rushton Turbine: Improving Data Treatment and Validation”, (with F. Chiti, S. Bakalis, W. Bujalski, M. Barigou and A. Eaglesham), Chem. Eng. Res. Des., (Trans. I Chem Eng. Part A), 89, (2011), 1947 -1960.
"Scale-Down/Scale-up Studies Leading to Improved Commercial Beer Fermentation", (with M. Nordkvist and C. J. Boulton), Biotechnol. J., 6, (2011), 911 – 925
“Expansion of Human Mesenchymal Stem Cells on Microcarriers”, (with C. J. Hewitt, K. Lee, R. J. Thomas, M. Smith and C. R. Thomas), Biotechnol. Letters, 33, (2011), 2325-2335
"Further Studies of Micromixing: Scale-up, Baffling and Feed Pipe Backmixing", (with M. Assirelli and S. P. Lee), J. Chem. Eng., Japan, 44, (2011), 901 -907.
“Lagrangian Tools for the Analysis of Mixing in Single- and Multi-Phase Flow Systems” (with A. Guida and M. Barigou), AIChE Journal, 58, (2012), 31 – 45.
“The Large Scale Expansion and Exploitation of Pluripotent Stem Cells for Regenerative Medicine Purposes: Beyond the T-Flask”, (with A. J. Want, C. J. Hewitt and K. Coopman), Regen. Med., 7, (2012), 71–84.
“On the Generation of Hydrogen Gas during the Catalytic Oxidation of Sodium Lignosulphonate to Vanillin: Initial Results”, (with P. Ding, M. Garrett, Ø. Loe and A.W. Pacek), Ind. Eng. Chem. Res., 51, (2012),184-188