Dr. Delgado-Saborit’s research interests are the measurement and modelling of inhalation doses and personal exposures to air pollutants and related health effects; the use of biomarkers as tracers of exposure and effects to air pollution; the monitoring and assessment of air pollution in indoor microenvironments and ambient air; the characterization of airborne nanoparticle exposures and related health effects; the implementation of real-time sensors and passive samplers to assess air quality and human exposures to airborne pollutants; and the study of sources and processes determining airborne pollutant concentrations in indoor and ambient air.
Her recent research projects are:
Use of real-time sensors to assess misclassification and to identify the contribution of main sources to peak and chronic exposures funded by the Health Effects Institute 2011 Walter A. Rosenblith New Investigator Award. The aim is to assess the degree of misclassification associated with the use of surrogate measures of exposure — such as measurements made at central monitors — and to identify key activities and sources of these pollutants. A panel study will be conducted to improve methods of estimating human exposure to the air pollutant mixture (specifically ultrafine particulate matter [PM], fine PM, black carbon, and nitrogen dioxide). The subjects will wear personal monitoring equipment for four consecutive days in winter and summer. A novel feature of this study is the use of sensors that can provide detailed data on pollutant concentrations over time and accelerometers to estimate subjects’ physical activity level so that equivalent respiration rates and inhaled doses can be calculated.
Development of in-vivo and in-vitro methodologies to assess oxidative stress caused by ambient pollutants funded by the Wellcome Trust Institutional Support Fund. The aim is to develop an analytical methodology suitable to detect multiple oxidative stress biomarkers both in-vivo and in-vitro systems and to apply this methodology to assess the association between oxidative stress and inhaled exposures to pollutants.
In Quest of New Fingerprints of Exposure to Air Toxics (FIXAT Project) funded by the Cefic 2010 LRI Innovative Science Award and subsidized by the Division of Environmental Health and Risk Management. The aims of the project are to characterise human exposures to a range of air toxics emitted from consumer products (VOCs) and combustion sources (PM2.5, PAH, quinones and black carbon); and to find suitable biomarkers to monitor the exposure and effects to low-level of VOCs, especially benzene, and other air toxics using novel analytical and cutting-edge methodologies
From Airborne exposures to BiologicaL Effects (FABLE): the impact of nanoparticles on health funded by NERC/MRC Environment and Health. This linked programme of work begins with measurement and identification of metallic nanoparticles in the air, focusing on those from vehicle exhausts, manufacturing particles in the lab which have similar properties to ambient levels, using these in the lab to see how they enter cells and move within cells and then what effects these particles have on cellular function. We will use real life doses which we will have obtained from our ambient measures. Throughout the grant we will interact with policy makers in a range of Government departments and agencies so that these findings can influence policy development in nanoparticle exposure
SPADE Project: Sources and atmospheric Processes determining Airborne concentrations of polycyclic aromatic hydrocarbons and their DEgradation products funded by NERC. The major goals of this project are to study the rates and mechanisms of degradation of airborne PAH and to evaluate concentrations of their reaction products.
Health Implications of Polycyclic Aromatic Hydrocarbons in Indoor Environments funded by the National Institute for Health Research Central Commissioning Facility (NIHR-CCF). Research on the Health Effects of Outdoor and Indoor Air Pollution and Policy Research Programme. The aims of the project are to characterize PAH indoors and to compare whether indoor profile and carcinogenic potency are similar to those outdoors.
MATCH Project: Measurement and modelling of exposure to Air Toxic Concentrations for Health effect studies & verification by biomarker funded by the Health Effects Institute. The major goals of this project are to characterize exposures to VOC and PAH in personal, indoor and outdoor environments; to develop models to predict those exposures; to assess relationship between personal exposures and biomarker concentrations to VOCs and PAHs.
Massimiliano Mascelloni, Juana Maria Delgado-Saborit, Nikolas J. Hodges and Roy M. Harrison. Study of Gaseous Benzene Effects Upon A549 Lung Epithelial Cells Using a Novel Exposure System. Toxicology Letters. Accepted on 25/05/2015. 10.1016/j.toxlet.2015.05.015
Brett Gantt, Shamia Hoque, Kathleen M. Fahey, Robert D. Willis, Juana Maria Delgado-Saborit, Roy M. Harrison, K. Max Zhang, David A. Jefferson, Markus Kalberer, Kristin L. Bunker, Joseph M. Conny, Prakacsh V. Bhave, Jason P. Weinstein, and Havala O. T. Pye (2015) Factors Affecting the Ambient Physicochemical Properties of Cerium-Containing Particles Generated by Nanoparticle Diesel Fuel Additive Use. Aerosol Science and Technology. 49:371–380
Delgado-Saborit JM, Stark CP and Harrison RM (2014) Use of a Versatile High Efficiency Multiparallel Denuder for the Sampling of PAHs in Ambient Air: Gas and Particle Phase Concentrations, Particle Size Distribution and Artifact Formation.Environmental Science and Technology, 48 (1), pp 499–507
Delgado-Saborit JM, Park HD and Cwiertny DM (2014) Emerging investigators: challenges and opportunities for research independence and innovation. Environ. Sci.: Processes Impacts, 16, 1169-1170
Brett Gantt, Shamia Hoque, Robert D. Willis, Kathleen Fahey, Juana M. Delgado-Saborit, Roy M. Harrison, Garnet B. Erdakos, Prakash V. Bhave, K. Max Zhang, Kasey Kovalcik, Havala O.T. Pye. (2014) Near-road modeling and measurement of cerium-containing particles generated by nanoparticle diesel fuel additive use. Environmental Science and Technology, 48, 10607−10613
Sanderson P, Delgado-Saborit JM, Harrison RM (2014) A Review of Chemical and Physical Characterisation of Atmospheric Metallic Nanoparticles. Atmospheric Environment. doi: 10.1016/j.atmosenv.2014.05.023 (Author’s copy)
Alam MS, Delgado-Saborit JM, Stark CP and Harrison RM (2014) Investigating PAH relative reactivity using congener profiles, quinone measurements and back trajectories. Atmos Chem and Phys, 14, 2467–2477. (Author’s copy)
Claudio Sartini, Stefano Zauli Sajani, Isabella Ricciardelli, Juana Mari Delgado-Saborit, Fabiana Scotto, Arianna Trentini, Silvia Ferrari and Vanes Poluzzi (2013) Ultrafine particle concentrations in the surroundings of an urban area: comparing downwind to upwind conditions using Generalized Additive Models (GAMs). Environmental Science: Processes & Impacts, 15, 2087-2095
Delgado-Saborit JM, Alam MS, Godri Pollitt KJ, Stark CP and Harrison RM (2013)Analysis of atmospheric concentrations of quinones and polycyclic aromatic hydrocarbons in vapour and particulate phases. Atmospheric Environment, 77, 974-982. (Author’s copy)
García-Aleix JR, Delgado-Saborit JM, Verdú-Martín G, Amigó-Descarrega JM and Esteve-Cano V (2013). Trends in arsenic levels in PM10 and PM2.5 aerosol fractions in an industrialized area. Environmental Science and Pollution Research,published online 11/07/2013.
Alam MS, Delgado-Saborit JM, Stark CP and Harrison RM (2013) Using atmospheric measurements of PAH and quinone compounds at roadside and urban background sites to assess sources and reactivity. Atmospheric Environment, 77, 24-35 (Author’s copy)
Abdullahi LK, Delgado-Saborit JM, Harrison RM (2013). Emissions and indoor concentrations of particulate matter and its specific chemical components from cooking: A review. Atmospheric Environment, 71: 260-294 (Author’s copy)
Delgado-Saborit (2012), Use of real-time sensors to characterise human exposures to combustion related pollutants. J. Environ. Monit., 14, 1824-1837
Delgado-Saborit JM, Stark CP, Harrison RM (2011) Carcinogenic potential, levels and sources of polycyclic aromatic hydrocarbon mixtures in indoor and outdoor environments and their implications for air quality standards. Environment International, Volume 37, Issue 2, Pages 383-392, Volume 37, Issue 2, Pages 383-392 , Volume 37, Issue 2, Pages 383-392
Delgado-Saborit JM, Aquilina NJ, Baker SJ, Meddings C, Harrison RM. (2011) “Relationship of personal exposure to volatile organic compounds to home, work and fixed site outdoor concentrations”. Science of the Total Environment, 409 478–488, 409 478–488 , 409 478–488
Harrison, RM, JM Delgado-Saborit, F Dor, R Henderson (2010) WHO Guidelines for Indoor Air Quality: Selected pollutants. Chapter 1 – Benzene. World Health Organization, Copenhagen, Denmark. Pp 15-54
H Choi, RM Harrison, H Komulainen, JM Delgado-Saborit (2010) WHO Guidelines for Indoor Air Quality: Selected pollutants. Chapter 6 – PAH. World Health Organization, Copenhagen, Denmark. Pp 289-346
Aquilina NJ, Delgado-Saborit JM, Gauci AP, Baker S, Meddings C, Harrison RM (2010). “Comparative modeling approaches for personal exposure to particle-associated PAH”. Environmental Science and Technology, 44: 9370–9376
Delgado-Saborit JM, Aquilina NJ, Baker SJ, Meddings C, Harrison RM (2010). "Determination of atmospheric particulate-phase polycyclic aromatic hydrocarbons from low volume air samples" Anal Methods, 2:231-242
Aquilina, NJ, Delgado-Saborit, JM, Meddings, C, Baker, S, Harrison, RM, Jacob Iii, P, Wilson, M, Yu, L, Duan, M & Benowitz, NL (2010) “Environmental and biological monitoring of exposures to PAHs and ETS in the general population”, Environ Int , 36 (7): 763-771
Harrison, R.M., Delgado-Saborit, J.M., Baker, S.J., Aquilina, N., Meddings, C., Harrad, S., Matthews, I., Vardoulakis, S. and Anderson, R. (2009). ). “Measurement and Modeling of Exposure to Selected Air Toxics for Health Effects Studies and Verification by Biomarkers”. HEI Research Report 143. Health Effects Institute, Boston, MA. . Health Effects Institute, Boston, MA.
Delgado-Saborit JM, Aquilina NJ, Baker SJ, Meddings C, Harrison RM. "Model development and validation of personal exposure to volatile organic compound concentrations". Environmental Health Perspectives. 117:1571-1579. doi:10.1289/ehp.0900561 117:1571-1579. doi:10.1289/ehp.0900561
Delgado-Saborit, JM, N. Aquilina, C. Meddings, S. Baker, Vardoulakis, S and R. M. Harrison. (2009) "Measurement of personal exposure to volatile organic compounds and particle associated PAH in three UK regions". Environmental Science and Technology, 43 (12), 4582-4588
Delgado-Saborit, J.M. (2009) Effects of Air Pollution on Citrus Trees. In: Tennant P, Benkeblia N (Eds) Citrus II. Tree and Forestry Science and Biotechnology 3 (Special Issue 1), 92-104.
Delgado-Saborit, J.M and V.J. Esteve-Cano (2008) Assessment of tropospheric ozone effects on citrus crops using passive samplers in a western Mediterranean area. Agriculture, Ecosystems & Environment, 124, 147-153
Delgado-Saborit, J.M and V.J. Esteve-Cano (2007) Field comparison of passive samplers versus UV-photometric analyser to measure surface ozone in a Mediterranean area. J. Environ. Monit., 9, 610 - 615
Delgado-Saborit, J.M. and Esteve-Cano, V (2006) Field Study of Diffusion Collection Rate Coefficients of a No2 Passive Sampler in a Mediterranean Coastal Area. Environmental Monitoring and Assessment. 02.06.2006, vol. 120, no. 1, pp. 327-345
Seung Joo Lee, Philip Demokritou, Petros Koutrakis and Juana M. Delgado-Saborit (2006) Development and evaluation of personal respirable particulate sampler (PRPS).Atmospheric Environment, Volume 40, Issue 2, January 2006, Pages 212-224