Part of the School Seminar Series
Speaker: Dr Charlotte Stagg, FMRIB, University of Oxford
Abstract: There has been a recent surge of interest in the use of non-invasive techniques such as Magnetic Resonance Spectroscopy (MRS) to quantify neurotransmitters within the brain. Increasing evidence from human MRS studies suggests that local GABA levels are behaviourally relevant in task performance and that various forms of plasticity can be linked to local decreases in inhibition. I will review the role of the modulation of inhibitory processing in plasticity, both in terms of motor learning and the recovery after stroke. I will also discuss some recent data demonstrating that transcranial stimulation approaches modulate local GABA levels and how that modulation can be related both to local and network-level function. Finally, I will put these findings in the context of the potential use of transcranial stimulation for rehabilitation after stroke.