Medical Statistics, Clinical Trials, Screening Studies, Observational studies, Pilot studies, Standardisation Methods, Cardiovascular Disease (Heart Failure, Stroke), Exercise, Thyroid Disease, Gastrointestinal disease (Dyspepsia, Irritable bowel disease)
Andrea is lead statistician for BAFTA. This trial of thrombo-prophylaxis in elderly patients with atrial fibrillation (AF) showed that even among elderly patients with AF, anticoagulation with warfarin was superior to aspirin for primary stroke prevention. The BAFTA follow-up study is currently underway.
Andrea is currently lead statistician on exercise intervention trials for reducing menopausal symptoms (ACTIVE WOMEN) and postnatal depression (PAMPeRS). She is also an applicant on several other funded physical activity trials.
ECHOES (Echocardiographic Heart of England Screening study)
Andrea continues to work on ECHOES, one of the world’s largest, intensively phenotyped and well cited cohorts of heart failure and left ventricular systolic dysfunction. Information was collected on over 6000 participants in the West Midlands including data on diagnosis, quality of life and mortality. The follow-up screening study of these participants, ECHOES-X, is due to be completed in 2011.
The MICE rule
Andrea was heavily involved with the development and validation of a clinical decision tool, to optimise referral for echocardiography of people identified in primary care with suspected heart failure. Research is now focusing on the prospective validation of the rule in GP practices (REFER).
As a key member of the Birmingham Irritable Bowel Syndrome Research Group, Andrea was involved with the development and validation of the Birmingham IBS Symptom Questionnaire. This tool is currently being utilised in clinical trials in the UK, Germany, Canada, Australia and the USA.