Research Theme within School of Biosciences: Molecular Microbiology
Bacterial chromosome biology, pathogenicity and stress response; high-throughput analysis of DNA binding events; single molecule analysis
DNA can be envisaged as a long piece of string and, just like string, if not carefully wound, DNA becomes a tangled mess. This presents a problem for living organisms because they have to package their string of DNA within the confines of a small compartment (the cell). Cells have evolved numerous mechanisms to package DNA and, for more complicated organisms (for example humans and plants) we have a reasonably good understanding of how these mechanisms work. However, our understanding of chromosome folding in bacteria (such as the familiar organisms E. coli and Salmonella) is less well developed.
David's laboratory is focused on understanding mechanisms of DNA folding in bacteria. David is also interested in how this process impinges upon gene expression, DNA replication and pathogenicity.