Dr Roger Grand

Dr Roger Grand

Institute of Cancer and Genomic Sciences
Reader In Experimental Cancer Sciences

Contact details

Address
Institute of Cancer and Genomic Sciences
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Roger Grand is a Reader in Experimental Cancer Studies.  Roger has published over 160 research papers, mainly in the fields of adenovirus virology and muscle biochemistry.  He has held numerous research grants including those from Cancer Research UK, MRC, Breast Cancer Campaign and AICR. 

His research has always been focused on the underlying causes of human disease with an emphasis on understanding the structure/function relationship of the proteins involved. Most recently, he has concentrated on understanding the role on novel proteins involved in the DNA damage response.

Qualifications

D.Sc. 1986, University of Birmingham
Ph.D. 1972 University of Leeds
B.Sc. 1969 Biochemistry, University of Sheffield

Biography

Roger Grand gained his B.Sc. in biochemistry at the University of Sheffield, in a department much influenced by Professor Hans Krebs.  Roger moved to Leeds for his Ph.D. in the field of physical biochemistry.  After a short post-doctoral fellowship at the University of London (Royal Holloway College) he joined Professor Sam Perry’s ‘muscle research group’ in the Department of Biochemistry in Birmingham. 

A decade later Roger changed tack and moved to the Department of Cancer Studies to join the `adenovirus research group’ with Professor Phil Gallimore.  They directed the group together until Phil Gallimore retired, since which time Roger has lead a group, mainly focussed on adenovirus research, but latterly with a considerable interest in the DNA damage response.

Teaching

MSc Clinical Oncology
MRes Cancer Sciences
BMedSci  Y3 Virology Module
BMedSci Y2 AMEG Module (director)
BMedSci Y1 IMEG Module
MBChB Cancer: Causes to Cures Module

Postgraduate supervision

Roger Grand has supervised about 20 PhD students, all of whom have successfully gained their degrees and most have gone on to do post-doctoral research.

He has also supervised a number of Masters students

Research

Roger Grand’s main research interest for the past thirty years has been in adenovirology with particular emphasis on the role of the early region1 (E1) proteins in viral infection and in adenovirus-mediated cell transformation.  While this has led to considerable progress in our understanding of the modes of action of the E1 proteins – in particular the E1A and E1B55K oncoproteins it has also helped in our understanding of various cellular pathways which are affected during infection or cellular transformation. 

Thus Roger has also published research papers dealing with the properties of p53, the retinoblastoma protein Rb, Ras, C-terminal binding protein (CtBP), C-terminal binding protein interacting protein (CtIP) and hnRNPUL-1.  He has also had a continuing interest in apoptosis.  Over the last five years Roger developed an interest in the DNA damage response, in both adenovirus and KSHV infected cells and in the absence of viral infection.  This work has concentrated on the characterization of a relatively recently isolated proteins hnRNPUL-1 (also known as E1B-AP5) and Tab182, both of which appear to function in RNA metabolism, transcriptional regulation and the DNA damage response.

Publications

Publications since 2010

 

Blackford,  A.N., Patel, R.N., Forrester, N.A., Theil, K., Groitl, P., Stewart, G.S., Taylor, A.M., Morgan, I.M., Dobner, T., Grand R.J., and Turnell, A.S. (2010) Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation. Proc Natl. Acad Sci USA, 107  12251-6.

Ablack, J.N., Pelka, P., Yousef, A.F., Turnell, A.S., Grand, R.J. and Mymryk, J.S. (2010) Comparison of E1ACR3 transcriptional activation across 6 different human adenovirus subgroups. J. Virol. 84, 12771-12781.

Forrester, N.A., Sedgwick, G.G., Thomas, A., Blackford, A.N., Speiseder, T., Dobner, T., Byrd, P.J., Stewart, G.S., Turnell, A.S. and Grand, R.J. (2010) Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection. J. Virol. 85, 2201-2211.

Berhane S., Aresté C., Ablack J.N., Ryan G.B., Blackbourn D.J., Mymryk J.S., Turnell A.S., Steele J.C., Grand R.J.(2011). Adenovirus E1A interacts directly with, and regulates the level of expression of, the immunoproteasome component MECL1. Virology. 421, 149-58.

Miller M.S., Pelka P., Fonseca G.J., Cohen M.J., Kelly J.N., Barr S.D., Grand R.J., Turnell A.S.,Whyte P., Mymryk J.S.(2012) Characterization of the 55-residue protein encoded by the 9S E1A mRNA of species C adenovirus. J Virol., 86, 4222-33.

 Turnell AS, Grand RJ. (2012) DNA viruses and the cellular DNA-damage response.   J Gen Virol.  2012 ;93(Pt 10):2076-97.

Polo S.E., Blackford A.N., Chapman J.R., Baskcomb L., Gravel S., Rusch A., Thomas A., Blundred R., Smith P., Kzhyshkowska J., Dobner T., Taylor A.M., Turnell A.S., Stewart G.S., Grand R.J., Jackson S.P.(2012) Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair. Mol Cell, 45, 505-4.

Forrester N.A., Patel R.N., Speiseder T., Groitl P., Sedgwick G.G., Shimwell N.J., Seed R.I., Catnaigh P.Ó., McCabe C.J., Stewart G.S., Dobner T., Grand R.J., Martin A., Turnell A.S. (2012) Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection. J Virol. 86, 3167-79.

Sedgwick G.G., Townsend K., Martin A., Shimwell N.J., Grand R.J.,  Stewart G.S., Nilsson J., Turnell A.S. (2014) Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome to regulate mitosis. Oncogene 32. 4622-33.

ThomasA., Perry T., Berhane S., OldreiveC. ,Zlatanou A., Williams L. R., Weston    V.J., StankovicT., KearnsP., Pors K., GrandR.J., StewartG.S. The dual acting anthraquinone Alchemix induces cell death independently ATM   and p53. Oncogene  34, 3336-48

Olcina M.M., Grand R.J. Hammond E.M. (2014) ATM activation in hypoxia-causes  and consequences. Mol Cell Onc . 1:1, e29903.

Hollingworth R, Skalka GL, Stewart GS, Hislop AD, Blackbourn DJ, Grand RJ.(2015)  Activation  of DNA Damage Response Pathways during Lytic Replication of  KSHV  Viruses; 7(6):2908-27.

Hollingworth R, Grand RJ. (2015)Modulation of DNA damage and repair pathways by human tumour viruses. Viruses.;7(5):2542-91

Grand RJ, Stewart GS. (2015) Alchemix, p53 and topoisomerase. Aging (Albany NY).;7(9):601-2

Ryan EL, Hollingworth R, Grand RJ. (2016) Activation of the DNA damage resp[onse by RNA viruses Biomolecules. ;6(1). pii: E2. doi: 10.3390/biom6010002