Roger Grand’s main research interest for the past thirty years has been in adenovirology with particular emphasis on the role of the early region1 (E1) proteins in viral infection and in adenovirus-mediated cell transformation. While this has led to considerable progress in our understanding of the modes of action of the E1 proteins – in particular the E1A and E1B55K oncoproteins it has also helped in our understanding of various cellular pathways which are affected during infection or cellular transformation. Thus Roger has also published research papers dealing with the properties of p53, the retinoblastoma protein Rb, Ras, C-terminal binding protein (CtBP), C-terminal binding protein interacting protein (CtIP) and hnRNPUL-1. He has also had a continuing interest in apoptosis. Over the last five years Roger developed an interest in the DNA damage response, in both adenovirus infected cells and in the absence of viral infection. This work has concentrated on the characterization of a relatively recently isolated protein hnRNPUL-1 (also known as E1B-AP5), which appears to function in RNA metabolism, transcriptional regulation and the DNA damage response.