CK2 abrogates the inhibitory effects of PRH/HHEX on prostate cancer cell migration and invasion and acts through PRH to control cell proliferation. Siddiqui YH, Kershaw RM, Humphreys EH, Marcolino de Assis Junior E, Chaudhri S, Padma-Jayaraman PS and Gaston K. Oncogenesis 2017 Jan 30;6(1):e293. doi: 10.1038/oncsis.2016.82.
Urokinase-type plasminogen activator (uPA) promotes angiogenesis by attenuating Proline-rich homeodomain protein (PRH) transcription factor activity and de-repressing vascular endothelial growth factor (VEGF) receptor expression. Stepanova V, Jayaraman PS, Zaitsev SV, Lebedeva T, Bdeir K, Kershaw R, Holman KR Parfyonova YV, Semina EV, Beloglazova EB, Tkachuk VA, and Cines, DB. Journal of Biological Chemistry 2016 Jul 15;291(29):15029-45. doi: 1074/jbc.M115.678490
Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion. Gaston K, Tsitsilianos MA, Wadey K and Jayaraman PS. Cell and Bioscience 2016 6:12 DOI 10.1186/s13578-016-0077-7.
PRH/Hhex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin. Kershaw, R M. Siddiqui Y H, Roberts, D., Jayaraman PS, and Gaston K. Oncogene 2014 Dec 4;33(49):5592-600. doi: 10.1038/onc.2013.496..
Proline Rich Homeodomain (PRH/HHEX) protein in the control of haematopoiesis and myeloid cell proliferation and its potential as a therapeutic target in myeloid leukaemias and other cancers. R.M. Kershaw, K. Gaston and P-S. Jayaraman. Book Chapter: Myeloid Cells: Biology & Regulation, Role in Cancer Progression and Potential Implications for Therapy (Peer reviewed) 2013. Editors: Spencer A. Douglas Nova Publishers ISBN: 978-1-62948-046-6
Dasatinib inhibits leukaemic cell survival by decreasing PRH/HHex phosphorylation resulting in increased repression of VEGF signalling genes. Noy PJ, Gaston KL and Jayaraman PS. Leukaemia Research 2012 36(11):1434-7.
Protein kinase CK2 inactivates PRH/Hhex using multiple mechanisms to derepress VEGF signalling genes and promote cell survival. Noy P, Williams H, Sawasdichai A, Jayaraman PS., and Gaston K. Nucleic Acids Research (IF 9.1) 2012 40:9008-20
The Proline-Rich homeodomain protein PRH/Hhex forms stable oligomers that are highly resistant to denaturation. Shukla A., Burton N., Jayaraman PS. and Gaston K. Plos One 2012 7(4): e35984.
The Transcription Factor Encyclopedia. Dimas Yusuf, Stefanie L Butland, et al., Noy P. and Jayaraman P.-S (Haematopoietically expressed homeobox) Genome Biology 2012 13 (3):R24
PRH/Hhex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling. Noy P, Williams H, Sawasdichai A, Gaston K, and Jayaraman PS. Mol. Cell Biol. 2010 30(9):2120-34
A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients. Oram SH, Thoms JA, Pridans C, Janes ME, Kinston SJ, Anand S, Landry JR, Lock RB, Jayaraman PS, Huntly BJ, Pimanda JE, and Göttgens B. Oncogene. 2010 29(43):5796-808
DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers. Soufi A, Sawasdichai A, Shukla A, Noy P, Dafforn T, Smith C, Jayaraman PS, and Gaston K. Nucleic Acids Research 2010 38(21):7513-25.
In situ subcellular fractionation of adherent and non-adherent mammalian cells. Sawasdichai A, Chen HT, Abdul Hamid N, Jayaraman PS, and Gaston K. J Vis Exp. 2010 Jul 23;(41).
Activation of Proteinase-Activated Receptor 2 Stimulates Soluble Vascular Endothelial Growth Factor Receptor 1 Release via Epidermal Growth Factor Receptor Transactivation in Endothelial Cells. Al-Ani B, Hewett PW, Cudmore MJ, Fujisawa T, Saifeddine M, Williams H, Ramma W, Sissaoui S, Jayaraman PS, Ohba M, Ahmad S, Hollenberg MD, and Ahmed A. Hypertension 2010 55(3):689-97.