Dr Christina Yap MSci, PhD, CStat

Institute of Cancer and Genomic Sciences
Principal Biostatistician

Contact details

Cancer Research UK Clinical Trials Unit (CRCTU)
Institute of Cancer and Genomic Sciences
College of Medical and Dental Sciences
University of Birmingham
B15 2TT

Dr Christina Yap is a Principal Biostatistician at Cancer Research UK Clinical Trials Unit (CRCTU), within the Institute of Cancer and Genomic Sciences. Her main expertise comprises of development and practical implementation of efficient designs in clinical trials. This includes innovative adaptive designs in early phase dose-finding trials, joint evaluation of safety and activity and randomized Phase II selection designs; as well as late-phase randomised (multi-stage) Phase II/III trials. Her other key areas of expertise include Bayesian designs and analysis in clinical trial and joint modelling of quality of life and survival.
She is the statistical lead for trials in various disease areas, which includes liver, head and neck, skin and leukaemia within the trials unit. 


  • Chartered Statistician 2010
  • PhD in Statistics, University of Glasgow, 2004
  • Associate Practitioner of the Higher Education Academy 2006
  • Master in Science (Mathematics and Statistics), University of Glasgow, 1999


  • Medicine and Surgery MBChB Year 2 Medical Statistics small group teaching
  • MSc in Clinical Oncology


  • Adaptive Trial Designs
  • Early Phase I/II trial designs, with a focus on dose-finding designs such as Continual Reassessment Method, joint evaluation of safety and activity and randomized Phase II selection designs
  • Implementation and analysis of innovative, efficient designs in clinical trials in various disease areas including leukaemia, head and neck, skin and liver
  • Bayesian designs and analysis in clinical trial
  • Flexible modelling
  • Acute and Chronic Health Effects of Air Pollution
  • Detecting discontinuity in time series and spatial data using nonparametric regression techniques

Other activities

  • Member of NCRI Non-Melanoma Skin Cancer Subgroup
  • Member of NCRI Clinical and Translational Radiotherapy Research Working Group (CTRad)
  • Member of the MRC Hub Network Adaptive Designs Working Group
  • West Midlands Research Design Service Advisor
  • Data Monitoring Committee Member


  • Craddock C, Jilani N, Siddique S, Yap C, Khan J, Nagra S, Ward J, Ferguson P, Hazlewood P, Buka R, Vyas P (2015). Tolerability and clinical activity of post-transplantation azacitidine in patients allografted for acute myeloid leukemia treated on the RICAZA trial. Biology of Blood and Marrow Transplantation. 29;22(2):385-90.
  • Mussai, F. J., Yap, C., Mitchell, C., & Kearns, P. (2015): Challenges of Clinical Trial Design for Targeted Agents Against Pediatric Leukemias. Frontiers in Oncology, 4, 374
  • Yap, C., Lin, X., & Cheung, Y. K. K. (2015). Sequential Elimination in Multi-Arm Selection Trials. Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects, 81, 411-426, edited by Sverdlov, A (ed)
  • Yap C, Pettitt A and Billingham L (2013):  Screened selection design for randomised phase II oncology trials: an example in chronic lymphocytic leukaemia.  BMC Med Res Methodol. 2013; 13: 87.
  • Yap C, Beverland IJ, Heal MR, Cohen GR, Robertson C, Henderson DEJ, Ferguson NS, Hart CL, Morris G and Agius RM (2012): Association between long-term exposure to air pollution and specific causes of mortality in Scotland. Occupational and Environmental Medicine, 2012, 69:916-924
  • Beverland I, Robertson C, Yap C, Heal, M.R. Cohen, G.R. Henderson, D.E.J, Hart, C.L. and Agius, R.M. (2012) Comparison of models for estimation of long-term exposure to air pollution in cohort studies. Atmospheric Environment, 62. 530-539.
  • Tho LM, Glegg M, Paterson J, Yap C, MacLeod A, McCabe M, McDonald AC (2006) Acute small bowel toxicity and preoperative chemoradiotherapy for rectal cancer: investigating dose-volume relationships and role for inverse planning. International Journal of Radiation Oncology, Biology, Physics 66(2): 505-13
  • Beverland IJ, Cohen GR,  Heal MR, Carder M,  Yap C, Robertson C, Hart CL and Agius RM (2012): A Comparison of Short-term and Long-term Air Pollution Exposure Associations with Mortality in Two Cohorts in Scotland Environ Health Perspect. 2012; 120(9): 1280–1285.
  • Walji N, Chue A L, Yap C,  Rogers L J, El-Modir A, Chan K K, Singh K, Fernando. I N (2010): Is There a Role for Adjuvant Hysterectomy after Suboptimal Concurrent Chemoradiation in Cervical Carcinoma? Clinical Oncology 2010, 22(2), 140–146
  • King A, Barton D, Beard H, Moore J, Than N, Corbett C, Thomas J, Guo K, Guha I, Hollyman D, Stocken D, Yap C, Fox R,  Forbes SJ and Newsome PN (2015): Repeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC), a multicentre, phase II, open-label, randomised controlled trial of repeated autologous infusions of granulocyte colony stimulating factor (GCSF) mobilised CD133+ bone marrow stem cells in patients with cirrhosis: study protocol for a randomised controlled trial. BMJ open 5.3 (2015): e007700.
  • Tho LM, McIntyre A, Rosst A, Gallagher C, Yap C, Ritchie DM, Canney PA (2006) Acute Supraclavicular Skin Toxicity in Patients Undergoing Radiotherapy for Breast Cancer; An Evaluation of the “T” Grip Method of Patient Positioning. Clinical Oncology 18(2):133-8