Constanze Bonifer studied Biology at the University of Cologne, Germany and graduated 1980 with a first class degree in Biochemistry, Chemistry and Genetics. She then went on to do a PhD in Biochemistry and Molecular Biology, first at the University of Cologne, then at the Centre for Molecular Biology (ZMBH), University of Heidelberg.
This was followed by Postdoctoral training periods at the Karolinska Institute, Stockholm, and the National Institute for Medical Research in London where she started to work on gene regulation.
1990 she became Assistant Professor and independent group leader at University of Freiburg, Germany, where she worked on gene regulation in the hematopoietic system.
1997 she went back to the UK and became a group leader at the Molecular Medicine Unit, University of Leeds, where she started to work not only on basic mechanisms controlling blood cell development, but also on epigenetic mechanisms controlling leukemogenesis.
She became a Reader in 2000, a Professor in 2003 and in 2004 became a full Professor and Chair of Experimental Haematology. In 2006 she was appointed Head of Section of Expeirmental Haematology at the Leeds Institute of Molecular Medicine.
Since August 2011, Constanze is in Birmingham as Chair of Experimental Haematology at the Institute of Biomedical Research.
Selected peer reviewed publications in the last five years:
Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia. Zhang H, Alberich-Jorda M, Amabile G, Yang H, Staber PB, Diruscio A, Welner RS, Ebralidze A, Zhang J, Levantini E, Lefebvre V, Valk PJ, Delwel R, Hoogenkamp M, Nerlov C, Cammenga J, Saez B, Scadden DT, Bonifer C, Ye M, Tenen DG (2013). Cancer Cell 24(5):575-88.
Piper, J., Elze, M., Cauchy, P., Cockerill, P.N*., Bonifer, C*. and Ott, S*. (*corr. Authors) (2013). Wellington: A novel method for the accurate identification of digital genomic footprints from DNase-seq data. Nucleic Acids Research. 41(21):e201
Lineage-inappropriate PAX5 expression in t(8;21) acute myeloid leukemia requires signaling-mediated abrogation of polycomb repression. Ray D, Kwon SY, Tagoh H, Heidenreich O, Ptasinska A, Bonifer C. Blood. 2013 Aug 1;122(5):759-69.
Ladopoulos, V., Hofemeister, H., Hoogenkamp, M., Riggs, A.D. Stewart, A.F. and Bonifer, C. (2013) Mechanistic insights into the function of MLL2 in CpG island promoter regulation. Mol Cell Biol. 33(7):1383-139
Lichtinger, M., Ingram, R.M., Hannah, R., Clarke, D., Müller, D., Lie-A-Ling, M., Noailles, L., Zhang, P., Wu, M., Tenen, D.G., Assi, S., Westhead, D.R., Kouskoff, V., Lacaud, G., Göttgens, B., and Bonifer, C. (2012) RUNX1 reshapes the epigenetic landscape at the onset of haematopoietic development. EMBO J. 31, 4318 - 4133
Ptasinska, A.; Assi, S.A., James, S.R.,Williamson, D.,Hoogenkamp, M., Mengchu, W., Care, M., McNeill, H., Cullen, M., Tooze, R., Tenen, D.G., Cockerill, P.N. Westhead, D.R.,Heidenreich, O. and Bonifer, C. (2012). Reversible genome-wide epigenetic reprogramming by the leukemia-initiating fusion protein RUNX1/ETO. Leukemia 26:1829-41
Lamprecht, B., Walter, K., Kreher, S., Kumar, R., Hummel, M., Lenze, D., Köchert, K., Bouhlel, M.A., Richter, J., Soler, E., Stadhouders, R., Jöhrens, C., Wurster, K.D., Callen, C., Harte, M.F., Giefing, M., Barlow, R., Stein, H., Anagnostopoulos, I., Janz, M., Cockerill, P.N., Siebert, R., Dörken, B., Bonifer, C.*, and Mathas, S.* (2010). (*Joint corresponding authors). De–repression of an endogenous long terminal repeat activates the CSF1R proto–oncogene in human lymphoma. Nature Medicine. 16, 571 – 579
Hoogenkamp, H.; Lichtinger, M.; Krysinska, H.; Lancrin, C.; Clarke, D.; Williamson, A.; Mazzarella,L.; Ingram, R.; H. Jorgensen, A. Fisher, D,G. Tenen, Kouskoff, V.; G.Lacaud, and C.Bonifer (2009). Early chromatin unfolding by Runx1 - a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program. Blood 114; 299-309.
And many more since 1986