Professor Charles Craddock is Director of the Blood and Marrow Transplant Unit at the Queen Elizabeth Hospital, Birmingham and Professor of Haemato-oncology at the University of Birmingham. He studied medicine at Oxford University and underwent postgraduate training in haematology at the Hammersmith Hospital, London, the Institute of Molecular Medicine at the University of Oxford and the Fred Hutchinson Cancer Research Centre at the University of Washington, Seattle.
In 1999 he was appointed Director of the Blood and Marrow Transplant Unit at the Queen Elizabeth Hospital, Birmingham and in 2004 took up a newly created Chair of Haemato-oncology at the University of Birmingham. In the last decade the BMT unit at the Queen Elizabeth Hospital has grown rapidly to become the second largest adult transplant programme in the United Kingdom. Over the same period he has led the development of a translational haemato-oncology programme in Birmingham and is Director of the recently established Centre for Clinical Haematology which houses an integrated clinical leukaemia and transplant programme and an early phase trial unit serving one of the largest catchment areas in Europe.
Professor Craddock is Chair of UK Stem Cell Strategic Forum which was established in 2010 to advise the Department of Health on the strategic development of alternative donor stem cell transplantation in the UK. In 2010 he was appointed Medical Director of the Anthony Nolan- one of the largest unrelated donor registries in the world. In 2011 he led a successful bid to establish a national haemato-oncology early phase trials programme- the Therapy Acceleration Programme.
He is a recent President of the British Society of Blood and Marrow Transplantation and is an active member of the NCRN Acute Myeloid Leukaemia Working Party. His main research interests include the development of novel drug and transplant therapies in myeloid leukaemias with particular reference to epigenetic and targeted therapies either prior to transplant or as adjunctive post-transplant therapy.
Craddock C. Epigenetic manipulation of the immune response: a novel treatment strategy in hematologic malignancies. Cytotherapy. 2011 May;13(5):516-7
Craddock, C. Labopin, M. Pillai, S. Finke, J. Bunjes, D. Greinix, H. Ehninger, G. Steckel, NK. Zander, AR. Schwerdtfeger,R. Buchholz, S. Kolb, HJ. Volin, L. Frauser, A. Polge, E. Schmid, C. Mohty, M. Rocha, V. (2011) Factors predicting outcome after unrelated donor stem cell transplantation in primary refractory acute myeloid leukaemia. Leukemia 2011 Feb 22 [Epub ahead of print]
Goardon, N. Marchi, E. Atzberger, A. Quek, L. Schuh, A. Soneji, S. Woll, P. Mead, A. Alford, KA. Rout, R. Chaudhury,S. Gilkes, A. Knapper,S. Beldjord, K. Begum, S. Rose, S. Geddes, N. Griffiths, M. Standen, G. Sternberg, A. Cavenagh, J. Hunter, H. Bowen, D. Killick, S. Robinson, S. Price, a. Macintyre, E. Virgo, P. Burnett, A. Craddock, C. Enver, T. Jacobsen, SE. Porcher, C. Vyas, P. Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia. Cancer Cell 2011 Jan 18;19(1):138-52.
Goodyear, O. Agathanggelou, A, Novitzky-Baso, I. Siddique, S. McSkeane, T. Ryan, G. Vyas, P. Cavenagh, J. Stankovic, T. Moss, P. (2010) Induction of a T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valporate in patients with acute myeloid leukaemia and myelodysplasia. Blood 2010 Sep 16; 116(11):1908-18 Epub 2010 Jun 8.
McLarnon, A. Piper, KP. Goodyear, OC. Arrazi, JM. Mahendra, P. Cook, M. Clark, F. Pratt, G, Craddock, C. Moss, PA. (2010) CD8(+) T-Cell immunity against cancer testis antigens develops following allogeneic stem cell transplantation and reveals a potential mechanism for the graft-versus-leukemia effect. Haematologica 2010 sep;95(9):1572-8. Epub 2010 May 11.
Craddock, C. Nagra, S. Peniket, A. Brookes, C. Buckley, L. Nikolousis, E. Duncan, N. Tauro, S. Yin, J. Liakopoulou, E. Kottaridis, P. Snowden, J. Milligan, D. Cook, G. Tholouli, E. Littlewood, T. Peggs, K. Vyas, P. Clark, P. Cook, M. Mackinnon, S Russell, N. (2009), Factors Predicting Long Term Survival After T Cell Depleted Reduced Intensity Allogeneic Stem Cell Transplantation for Acute Myeloid Leukaemia. Haematologica Nov 30 [Epub ahead of print]
Olavarria, E. Siddique, S. Griffiths, M. Avery, S. Byren, JL. Piper, K. Lennard, A. Pallan, L. Arrazi, K. Perz, J. O’Shea, D. Goldman, J. Apperley, JF. Craddock, C. (2008), Post- transplant Imatir as a Strategy to Postpone the Requirement for Immunotherapy in Patients undergoing Reduced Intensity Allografts for Chronic Myeloid Leukemaia. Blood Dec 15;110(13):4614
Craddock, C. Chakraverty, R. (2011), "Stem Cell Transplantation", In: Hoffbrand, V. Catovsky D, Edward GD. Tuddenham. Green, AR. (eds.) Postgraduate Haematology. Wiley-Blackwell, pp. 722-745