Joanne Croudace qualified with a BSc (Hons) in Biochemistry and Neuroscience from Keele University, Staffordshire in 2004. She went on to specialise in the field of cellular immunology, studying a Masters of Research (awarded in 2005) at the University of Birmingham’s Institute for Biomedical Research. The major focus was the role of invariant Natural Killer T (iNKT) cell ligands as adjuvants for dendritic cell (DC) immunotherapy. This interest was continued through to PhD level with her doctorate, awarded in 2009, titled ‘The iNKT cell ligand alpha-Galactosylceramide as an adjuvant for human dendritic cell immunotherapy’.
Following her doctorate, Joanne continued her work in the field of human cellular immunology in the group of Professor Paul Moss at the Institute for Cancer Research, School of Cancer Sciences. The major focus of her studies is the pathogenesis of Graft versus Host disease (GVHD) post allogeneic stem cell transplantation, a tissue-specific disease resulting in destruction of the skin, gut and liver.
Stem cell transplantation, Graft versus Host disease, Graft versus Leukaemia, chemokines, dendritic cell immunotherapy.
Graft-versus-host disease (GVHD)
Over the last 2 years, the main emphasis of Joanne’s work has been on determining the pathogenesis of Graft versus Host disease (GVHD) and in particular the role that chemokines and their receptors play in this tissue-specific disease.
The work focuses on the identification of specific chemokines, and their receptors, that are involved in the development and control of skin GVHD and on the potential of these chemokines to be targets for therapy.
Croudace JE, Curbishley S, Mura M, Willcox C, Illarionov PE, Besra GS, Adams DH, Lammas DA, (2008), Identification of Distinct Human Invariant Natural Killer T-Cell Response Phenotypes To α-galactosylceramide, BMC Immunol, 9:71.
Debasis Biswas,Omar S Qureshi, Wing-Yiu Lee, Joanne E Croudace, Manuela Mura, and David A Lammas, (2008). ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages, BMC Immunol, 9:35.
Ma H, Croudace JE, Lammas DA, May RC. Direct cell-to-cell spread of a pathogenic yeast (2007), BMC Immunol, 8:15.
Mutalithas K*, Croudace J*, Guillen C, Siddiqui S, Thickett D, Wardlaw A, Lammas D, Brightling C, (2007), Bronchoalveolar lavage invariant natural killer T cells are not increased in asthma, J Allergy Clin Immunol, 119(5):1274-6. *Authors contributed equally.
Ma H, Croudace JE, Lammas DA, May RC, (2006), Expulsion of live pathogenic yeast by macrophages, Curr Biol, 16(21):2156-60.
Joe M, Sun D, Taha H, Completo GC, Croudace JE, Lammas DA, Besra GS, Lowary TL, (2006), The 5-deoxy-5-methylthio-xylofuranose residue in mycobacterial lipoarabinomannan. absolute stereochemistry, linkage position, conformation, and immunomodulatory activity, J Am Chem Soc, 128(15):5059-72.