Lee Middleton is a Medical Statistician at the Birmingham Clinical Trials Unit.
He is currently involved with numerous randomised controlled trials, diagnostic accuracy studies and systematic reviews. The majority of this work is focused on obstetric and gynaecological health issues in collaboration with the Birmingham Women’s Hospital.
After qualifying with an MSc in Statistics in 2001, Lee worked as a Statistician at Syngenta Central Toxicology Laboratory (formerly Zeneca Agrochemicals) in the Regulatory Toxicity department. Here he provided statistical support on toxicological and pre-clinical studies.
After six years at Syngenta Lee took his first University role as a Medical Statistician at the Birmingham Clinical Trials Unit.
Lee is currently working on a number of NIHR HTA funded randomised controlled trials and diagnostic studies in obstetrics and gynaecology which are at various stages of completion. This portfolio of studies continues to grow with recent funding awards. He has also recently completed large individual patient data meta-analysis projects in this field.
Lee is also the statistician in randomised controlled trials of knee cartilage repair by autologous chondrocyte transplantation and surgical treatments for rectal prolapse.
Clark TJ, Samuel N, Malick S, Middleton LJ, Daniels J, Gupta JK. Bipolar radiofrequency compared with thermal balloon endometrial ablation in the office: a randomised controlled trial. Obstet Gynecol 2011;117:109-118
Daniels JP, Middleton LJ, Xiong T, Champaneria R, Johnson NP, Lichten EM, et al. Individual patient data meta-analysis of randomized evidence to assess the effectiveness of laparoscopic uterosacral nerve ablation in chronic pelvic pain. Hum Reprod Update 2010;16:568-76
Middleton LJ, Champaneria R, Daniels JP, Bhattacharya S, Cooper KG, Hilken NH, et al. Hysterectomy, endometrial destruction, and levonorgestrel releasing intrauterine system (Mirena) for heavy menstrual bleeding: systematic review and meta-analysis of data from individual patients. BMJ 2010;341:c3929
Moore J, Middleton LJ, Cockwell P, D Adu, Ball S, Little M, et al. Calcineurin Inhibitor Sparing with Mycophenolate in Kidney Transplantation: A Systematic Review and Meta-Analysis. Transplantation 2009;87:591-605.