Mr Lee Middleton BSc, MSc

 

Senior Statistician

School of Cancer Sciences

Contact details

Birmingham Clinical Trials Unit
Robert Aitken Institute
School of Cancer Sciences
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

About

Lee Middleton is a Senior Medical Statistician at the Birmingham Clinical Trials Unit.

He is currently involved with numerous randomised controlled trials, diagnostic accuracy studies and systematic reviews. The majority of this work is focused on obstetric and gynaecological health issues in collaboration with the Birmingham Women’s Hospital.

Qualifications

  • MSc Statistics, University of Kent, 2001
  • BSc Mathematics, University of Manchester, 1998

Biography

After qualifying with an MSc in Statistics, Lee worked as a Statistician at Syngenta Central Toxicology Laboratory (formerly Zeneca Agrochemicals) in the Regulatory Toxicity department. Here he provided statistical support on toxicological and pre-clinical studies.

After six years at Syngenta Lee took his first University role as a Medical Statistician at the Birmingham Clinical Trials Unit (BCTU). Lee is now a Senior Statistician at BCTU and is the Statistics Lead for the growing portfolio of Women's Health studies.

Teaching

  • MBChB Cancer ‘causes to cures’ tutor, School of Cancer Sciences 
  • MBChB statistics tutor, School of Health and Population Sciences 
  • Research Methods Course, Birmingham Clinical Trials Unit

Publications

Morris RK, Malin GL, Quinlan-Jones E, Middleton LJ, Hemming K, Burke D, et al. Percutaneous vescioanniotic shunting versus conservative management for fetal lower urinary tract obstruction (PLUTO): a randomised trial. Lancet 2013 Aug 13 epub ahead of print

Senapati A, Gray RG, Middleton LJ, Harding J, Hills RK, Armitage NCM, et al PROSPER: a randomised comparison of surgical treatments for rectal prolapse. Colorectal Disease 2013 epub ahead of print

Gupta J, Kai J, Middleton LJ, Pattison H, Gray R, Daniels JP. Levonorgestrel Intrauterine System versus medical therapy for menorrhagia. N Engl J Med 2013;368:128-37

Powell R, Pattison HM, Bhoyar A, Furmston AT, Middleton LJ, Daniels JP, et al. Pulse oximetry screening for congenital heart defect in newborn infants: an evaluation of acceptability to mothers. Arch Dis Child 2012; 2013;98:F59-63

Daniels JP, Middleton LJ, Champaneria R, Khan KS, Cooper K, Mol BWJ, et al. Second generation endometrial ablation techniques for heavy menstrual bleeding: network meta-analysis. BMJ 2012;344:e2564

Roberts TE, Barton PM, Auguste PE, Middleton LJ, Furmston AT, Ewer AK. Pulse oximetry as a screening rest for congenital heart defects in newborn infants: a cost-effectiveness analysis. Arch Dis Child 2012;97:221-226

Ewer AK, Middleton LJ, Furmston AT, Bhoyar A, Daniels JP, Thangaratinam S. Pulse oximetry as a screening rest for congenital heart defects in newborn infants: the PulseOx test accuracy study. Lancet 2011;378:785-94

Roberts TE, Tsourapas A, Middleton LJ, Champaneria R, Daniels JP, Cooper KG, et al. Hysterectomy, endometrial ablation, and levonorgestrel releasing intrauterine system (Mirena) for treatment of heavy menstrual bleeding: cost effectiveness analysis. BMJ 2011;342:d2202

Clark TJ, Samuel N, Malick S, Middleton LJ, Daniels J, Gupta JK. Bipolar radiofrequency compared with thermal balloon endometrial ablation in the office: a randomised controlled trial. Obstet Gynecol 2011;117:109-118

Daniels JP, Middleton LJ, Xiong T, Champaneria R, Johnson NP, Lichten EM, et al. Individual patient data meta-analysis of randomized evidence to assess the effectiveness of laparoscopic uterosacral nerve ablation in chronic pelvic pain. Hum Reprod Update 2010;16:568-76

Middleton LJ, Champaneria R, Daniels JP, Bhattacharya S, Cooper KG, Hilken NH, et al. Hysterectomy, endometrial destruction, and levonorgestrel releasing intrauterine system (Mirena) for heavy menstrual bleeding: systematic review and meta-analysis of data from individual patients. BMJ 2010;341:c3929

Moore J, Middleton LJ, Cockwell P, D Adu, Ball S, Little M, et al. Calcineurin Inhibitor Sparing with Mycophenolate in Kidney Transplantation: A Systematic Review and Meta-Analysis. Transplantation 2009;87:591-605

Back to top