Michael Overduin is the Professor of Structural Biology within the School of Cancer Sciences of the University of Birmingham, and Executive Director of The Henry Wellcome Building for Biomolecular NMR Spectroscopy.
Michael graduated with a BSc in Biology from Wilfrid Laurier University, Canada in 1988. He received his PhD in Biochemistry, Genetics and Physical Chemistry from The Rockefeller University in 1993. Michael then post-doctored at the University of Toronto for two years, prior to joining the University of Colorado Health Sciences Center as an Assistant Professor of Pharmacology in 1995. While there, Michael helped to establish a new NMR spectroscopy facility with funding from the Howard Hughes Medical Institute and the Program in Biomolecular Structure. He was promoted to Associate Professor by the University of Colorado School of Medicine in 2002.
In 2003, Michael moved to Birmingham as the Professor of Structural Biology, and was awarded JREI and Joint Infrastructure funding from HEFCE and the Wellcome Trust to establish the UK’s national 900 MHz NMR facility. He serves as Executive Director of the Henry Wellcome Building for Biomolecular NMR Spectroscopy (HWB•NMR), which is now an internationally recognised, large scale scientific facility with a global community of users and collaborators.
Since moving to the UK in 2003, Michael has been awarded over £12m in research funding from the BBSRC, Cancer Research UK, European Commission, MRC, and Wellcome Trust. In 2009, he became the Head of the Structural Biology & Biomarkers Theme in order to develop the University’s translational activities, including building drug discovery partnerships, and stimulate collaborative research into biodiagnostics. Michael led international EU PRISM and Japan Partnering consortia to broaden the take-up of membrane protein analysis and production technologies, and initiated the WW-NMR consortium of international large scale NMR facilities, which has been awarded funding from the EU’s IRSES program.
Commercial outputs include the patented styrene maleic acid lipid particle (SMALP) system, which has been used by a range of academic and industry groups for the analysis and exploitation of transmembrane protein targets. He formed Science Capital in 2010 to help bring together scientists, investors and business experts, and organises meetings to enable partnerships to be formed.
Among Michael’s awards are a Royal Society Wolfson Research Merit Award (2004-2009), University of Birmingham Chair of Structural Biology (2003), University of Colorado Department of Pharmacology Faculty Excellence in Research Award (2001), National Institutes of Health FIRST Award (1998), Pew Scholar Award (1998), Basil O'Conner Award (1998), Howard Hughes Medical Institute Junior Faculty Award (1997), Wilfrid Laurier University Alumnus of the Year (1995), National Cancer Institute of Canada Postdoctoral Fellowship (1993), and Wilfrid Laurier University Gold Medal in Biology (1988).
Kiran, MR, SM Di Pietro, JM. Olson, GS Payne, M Overduin (2007) Solution structure of Sla1 Homology domain 1 and NPFxD motif recognition responsible for endocytic cargo internalisation, EMBO J, 26(7):1963-71
Kami, K, T Dafforn, M Chidgey, M Overduin (2009) The desmoglein specific cytoplasmic region is intrinsically disordered in solution, J Mol Biol, 386(2):531-43.
Knowles, TJ, R Finka, C Smith, YP Lin, T Dafforn, M Overduin (2009) Membrane proteins solubilized intact in lipid containing nanoparticles bounded by styrene maleic acid copolymer, J Amer Chem Soc, 131(22):7484-5.
Cao, X, Ü Coskun, SB Buschhorn, M Grzybek, M Roessle, TR Dafforn, M Lenoir, M Overduin, K Simons (2009) The Golgi protein FAPP2 tubulates membranes, PNAS USA 106(50):21121-21125.
Lenoir, M, Ü Coskun, M Grzybek, X Cao, SB Buschhorn, J James, K Simons, M Overduin, (2010) Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains, EMBO R,11(4):279-84.
Rajesh, S. TJ Knowles, M Overduin (2011) Production of membrane proteins without cells or detergents, N Biotechnology 28(3):250-4.
Wolny MD, Grzybek M, Bok E, Chorzalska AD, Czogalla A, Lenoir M, Adamczyk K, Kolondra A, Diakowski W, Overduin M, Sikorski AF (2011) Key amino acid residues of ankyrin-sensitive phosphatidylethanolamine/ phosphatidylcholine-lipid binding site of βI–spectrin, PLoS One. 2011;6(6):e21538
Knowles, TJ, DF Browning, M Jeeves, R Maderbocus, S Rajesh, P Sridhar, E Manoli, D Emery, U Sommer, A Spencer, DL Leyton, D Squire, RR Chaudhuri, MR Viant, AF Cunningham, IR Henderson, M Overduin (2011) Structure and function of BamE within the outer membrane and the β-barrel assembly machine, EMBO R, 12(2):123-8.
Al-Jassar C, Knowles T, Jeeves M, Kami K, Bikker H, Overduin M, Chidgey M (2011) The nonlinear structure of the desmoplakin plakin domain and the effects of cardiomyopathy-linked mutations, J Mol Biol, 411(5):1049-61
Rajesh S, Bago R, Odintsova E, Muratov G, Sridhar P, Rajesh S, Overduin M, Berditchevski F (2011) Binding to syntenin-1 defines a new mode of ubiquitin-based interactions regulated by phosphorylation, J Biol Chem. 286(45):39606-14.