Dan Tennant is a Lecturer in the School of Cancer Sciences.
He has recently moved to Cancer Sciences to set up his group to study hypoxia and cancer metabolism. Dan has already attracted funding from the Royal Society to support his work. He has published reviews in top journals, such as Cell and Nature Reviews Cancer, as has been invited to speak at International Conferences.
Dan’s area of expertise is in the oxygen sensing and the hypoxic regulation of metabolism. His laboratory contains the specialised equipment necessary to carry out this work, including a Don Whitley Hypoxystation. His close collaborations with Ulrich Günther at the UK’s largest NMR facility (Henry Wellcome Building) and Mark Viant at the Advanced Mass Spectrometry Facility, both of which are situated in Birmingham, allows him to perform cutting edge metabolic flux analysis research to study cellular metabolism.
Dan Tennant graduated with a BA (Hons) and MSci from the University of Cambridge in 2002. He went on to Manchester University to study for his PhD with Professors Caroline Dive and David Tomlinson. During this time, he developed a strong interest in low oxygen (hypoxia) and the means by which cells survive these conditions.
He then undertook a post-doctoral research post in the laboratory of Professor Eyal Gottlieb, studying tumour hypoxia and metabolism, and in particular a family of enzymes that sense cellular oxygen levels, known as Prolyl Hydroxylases (PHDs).
After just over five years, Dan started his own group at the University of Birmingham to investigate the ways in which cells alter their metabolism in order to survive hostile environments.
Heiserich L., Caswell P.T., Unwin R.D., Campbell A.D., Knevels E., Schwartz J.P., Tennant D.A., Bienvenut W., Anderson K.I., Carmeliet P., Machesky L.M., Norman J.C., Gottlieb E., (2011), Inhibition of prolyl hydroxylation and polymerisation of β-actin drives hypoxia-induced cell migration and invasion, Nature Cell Biology, submitted
Frezza C., Zheng L., Tennant D.A., Gottlieb E., (2011), Metabolic profiling of hypoxic cells revealved a catabolic profile required for cell survival, PLoS ONE, 6(9):e24411
Tennant D.A., (2011), PK-M2 makes cells sweeter on HIF1, Cell, 145:647-9
Tennant D.A. and Gottlieb E., (2010), HIF Prolyl Hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression, Journal of Molecular Medicine, 88:839-49
Tennant D.A. and Gottlieb E., (2010), Targeting metabolic transformation for cancer therapy, Nature Reviews Cancer, 10:267-77
Frezza C., Tennant D.A., Gottlieb E., (2010), IDH1 mutations in gliomas: when an enzyme loses its grip, Cancer Cell, 17:7-9
Tennant D.A., Frezza C., MacKenzie E.D., Nguyen Q.D., Zheng L., Selak M.A., Roberts D.L., Dive C., Watson D.G., Aboagye E.O., Gottlieb E., (2009), Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death, Oncogene, 28:4009-21
Tennant D.A., Durán R.V., Boulahbel H., Gottlieb, E., (2009), Metabolic transformation in cancer, Carcinogenesis, 30:1269-80