Recent publications
Article
Fennell, É, Taylor, GS, Leahy, CI, Ross, AM, Reynolds, G, Perry, T, Youd, E, Skidmore, J, Ramzi, R, Darwish, R, Hunter, KJ, Willcox, BE, Jermann, P, Arif Jahangir, C, Rahman, A, Gallagher, WM, Nikulina, N, Ben Cheikh, B, Braubach, O, Mayer, AT, Young, LS, Grammatopoulos, D, Faustini, S, Richter, A, Dowell, AC, Venith, T, Thein, OS, Parekh, D, Belchamber, KBR, Thickett, DR, Scott, A, Attanoos, R, Mundo, L, Lazzi, S, Leoncini, L, Leopold, G, Steven, N, Marie, J, Sand, B, Karsdal, MA, Julie Leeming, D, Dojcinov, S, Culhane, A, Murray, PG & Pugh, MR 2025, 'Multi-omic spatial profiling reveals the unique SARS-CoV-2 lung microenvironment and collagen VI as a predictive biomarker in severe COVID-19', The European respiratory journal, vol. 66, no. 3, 2301699. https://doi.org/10.1183/13993003.01699-2023
Syrimi, E, Khan, N, Murray, P, Willcox, C, Haigh, T, Willcox, B, Masand, N, Bowen, C, Dimakou, DB, Zuo, J, Barone, SM, Irish, JM, Kearns, P & Taylor, GS 2024, 'Defects in NK cell immunity of pediatric cancer patients revealed by deep immune profiling', iScience. https://doi.org/10.1016/j.isci.2024.110837
Brooks, JM, Zheng, Y, Hunter, K, Willcox, BE, Dunn, J, Nankivell, P, Gevaert, O & Mehanna, H 2024, 'Digital Spatial Profiling identifies distinct patterns of immuno-oncology-related gene expression within oropharyngeal tumours in relation to HPV and p16 status', Frontiers in Oncology, vol. 14, 1428741. https://doi.org/10.3389/fonc.2024.1428741
Xu, Q, Sharif, M, James, E, Dismorr, JO, Tucker, JHR, Willcox, BE & Mehellou, Y 2024, 'Phosphonodiamidate prodrugs of phosphoantigens (ProPAgens) exhibit potent Vγ9/Vδ2 T cell activation and eradication of cancer cells', RSC Medicinal Chemistry, vol. 15, no. 7, pp. 2462-2473. https://doi.org/10.1039/d4md00208c
Talhouni, S, Fadhil, W, Mongan, NP, Field, L, Hunter, K, Makhsous, S, Maciel-Guerra, A, Kaur, N, Nestarenkaite, A, Laurinavicius, A, Willcox, BE, Dottorini, T, Spendlove, I, Jackson, AM, Ilyas, M & Ramage, JM 2023, 'Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers', Frontiers in immunology, vol. 14, 3389. https://doi.org/10.3389/fimmu.2023.1057292
Karunakaran, MM, Subramanian, H, Jin, Y, Mohammed, F, Kimmel, B, Juraske, C, Starick, L, Nöhren, A, Länder, N, Willcox, CR, Singh, R, Schamel, WW, Nikolaev, VO, Kunzmann, V, Wiemer, AJ, Willcox, BE & Herrmann, T 2023, 'A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human γδ T cell phosphoantigen sensing', Nature Communications, vol. 14, no. 1, 7617 . https://doi.org/10.1038/s41467-023-41938-8
Degirmencay, A, Thomas, S, Mohammed, F, Willcox, BE & Stauss, HJ 2023, 'Modifications outside CDR1, 2 and 3 of the TCR variable β domain increase TCR expression and antigen-specific function', Frontiers in immunology, vol. 14, 1148890. https://doi.org/10.3389/fimmu.2023.1148890
Willcox, CR, Salim, M, Begley, CR, Karunakaran, MM, Easton, EJ, von Klopotek, C, Berwick, KA, Herrmann, T, Mohammed, F, Jeeves, M & Willcox, BE 2023, 'Phosphoantigen sensing combines TCR-dependent recognition of the BTN3A IgV domain and germline interaction with BTN2A1', Cell Reports, vol. 42, no. 4, 112321. https://doi.org/10.1016/j.celrep.2023.112321
McMurray, J, von Borstel, A, Taher, T, Syrimi, E, Taylor, G, Sharif, M, Rossjohn, J, Remmerswaal, E, Bemelman, F, Vieira Braga, FA, Chen, X, Teichmann, SA, Mohammed, F, Berry, A, Lyke, K, Williamson, K, Stubbington, M, Davey, M, Willcox, C & Willcox, B 2022, 'Transcriptional profiling of human Vδ1 T cells reveals a pathogen-driven adaptive differentiation program', Cell Reports, vol. 39, no. 8, 110858. https://doi.org/10.1016/j.celrep.2022.110858
Faustini, S, Jossi, S, Perez-Toledo, M, Shields, A, Allen, JD, Watanabe, Y, Newby, ML, Cook, A, Willcox, C, Salim, M, Goodall, M, Heaney, J, Marcial Juarez, E, Morley, G, Torlinska, B, Wraith, D, Veenith, T, Harding, S, Jolles, S, Mark, PJ, Plant, T, Huissoon, A, O’Shea, MK, Willcox, B, Drayson, M, Crispin, M, Cunningham, A & Richter, A 2021, 'Development of a high-sensitivity ELISA detecting IgG, IgA and IgM antibodies to the SARS-CoV-2 spike glycoprotein in serum and saliva', Immunology, vol. 164, no. 1, pp. 135-147. https://doi.org/10.1111/imm.13349
Chapter (peer-reviewed)
Willcox, B & Willcox, C 2024, Exploiting fundamental γδ T cell immunobiology in cancer immunotherapy. in M Barisa (ed.), γδ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation. 1 edn, Elsevier, pp. 1-33. https://doi.org/10.1016/B978-0-443-21766-1.00004-7
Letter
Perez-Toledo, M, Faustini, SE, Jossi, SE, Shields, AM, Marcial‐Juarez, E, Kanthimathinathan, HK, Allen, JD, Watanabe, Y, Goodall, M, Willcox, BE, Willcox, CR, Salim, M, Wraith, DC, Veenith, TV, Syrimi, E, Drayson, MT, Jyothish, D, Al‐Abadi, E, Chikermane, A, Welch, SB, Masilamani, K, Hackett, S, Crispin, M, Scholefield, BR, Cunningham, AF & Richter, AG 2021, 'SARS‐CoV‐2‐specific IgG1/IgG3 but not IgM in children with Pediatric Inflammatory Multi‐System Syndrome', Pediatric allergy and immunology, vol. 32, no. 5, pp. 1125-1129. https://doi.org/10.1111/pai.13504
Literature review
Mohammed, F, Willcox, C & Willcox, B 2025, 'A triple take on antigen receptor recognition of PE', Structure, vol. 33, no. 10, pp. 1625-1627. https://doi.org/10.1016/j.str.2025.08.014
Preprint
Pugh, M, Fennell, E, Leahy, CI, Perry, T, Hargitai, B, Marton, T, Hunter, K, Halford, G, Yilmaz, HO, Stamataki, Z, Reynolds, G, Hill, HJ, Willcox, BE, Steven, N, Thornton, CA, Dojcinov, SD, Culhane, A, Murray, PG & Taylor, GS 2022 'Multi-omic spatial profiling reveals the unique virus-driven immune landscape of COVID-19 placentitis' bioRxiv. https://doi.org/10.1101/2022.11.14.516398
Review article
Gunn, JL, Rubina, A, Fielding, CA, Mohammed, F, Wang, ECY, Willcox, CR & Willcox, BE 2026, 'Auguries of adaptivity: LES γδ-TCR ligand recognition revisited', Trends in Immunology, vol. 47, no. 2, pp. 106-118. https://doi.org/10.1016/j.it.2025.10.006
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