Dr Larissa Fabritz

Dr Larissa Fabritz

Institute of Cardiovascular Sciences
Senior Clinical Lecturer in Cardiovascular Sciences

Contact details

Address
Institute of Cardiovascular Sciences
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Larissa Fabritz studies novel mechanisms of heart disease and performs translational research towards mechanism-based therapies of cardiovascular diseases. As a clinical consultant, she sees patients in the department of Cardiology at UHB. Dr Larissa Fabritz engages in research on molecular mechanisms of cardiomyopathies and arrhythmias as well as molecular cardiovascular imaging with her working group at the University of Birmingham, collaborations at the University of Muenster, Germany and throughout Europe and the United States.

Qualifications

  • 2012 Fellow of the European Society of Cardiology
  • 2012 Habilitation Internal Medicine “Towards molecular mechanism-based therapy of cardiomyopathies and arrhythmias”
  • 2011 GMC accreditation
  • 2010 Board Certification in Medicine
  • 1998 Thesis summa cum laude
  • 1997 Graduation from Medical School

Research

  • Molecular mechanisms of arrhythmias and cardiomyopathies
  • Molecular mechanisms of atrial fibrillation and atrial thrombosis
  • Sodium channel dysfunction
  • Desmosomal proteins

Publications

Fabritz L, Guasch E, Antoniades C, Bardinet I, Benninger G, Betts TR, Brand E, Breithardt G, Bucklar-Suchankova G, Camm AJ, Cartlidge D, Casadei B, Chua WW, Crijns HJ, Deeks J, Hatem S, Hidden-Lucet F, Kääb S, Maniadakis N, Martin S, Mont L, Reinecke H, Sinner MF, Schotten U, Southwood T, Stoll M, Vardas P, Wakili R, West A, Ziegler A, Kirchhof P. Expert consensus document: Defining the major health modifiers causing atrial fibrillation: a roadmap to underpin personalized prevention and treatment. Nat Rev Cardiol. 2015 Dec 24. doi: 10.1038/nrcardio.2015.194. [Epub ahead of print]


Fabritz L. The power of P in the elderly: Small biphasic wave, big impact. Heart Rhythm. 2015 Nov 18. pii: S1547-5271(15)01434-4. doi: 10.1016/j.hrthm.2015.11.027. [Epub ahead of print] No abstract available.

Kirchhof P, Breithardt G, Bax J, Benninger G, Blomstrom-Lundqvist C, Boriani G, Brandes A, Brown H, Brueckmann M, Calkins H, Calvert M, Christoffels V, Crijns H, Dobrev D, Ellinor P, Fabritz L, Fetsch T, Freedman SB, Gerth A, Goette A, Guasch E, Hack G, Haegeli L, Hatem S, Haeusler KG, Heidbüchel H, Heinrich-Nols J, Hidden-Lucet F, Hindricks G, Juul-Möller S, Kääb S, Kappenberger L, Kespohl S, Kotecha D, Lane DA, Leute A, Lewalter T, Meyer R, Mont L, Münzel F, Nabauer M, Nielsen JC, Oeff M, Oldgren J, Oto A, Piccini JP, Pilmeyer A, Potpara T, Ravens U, Reinecke H, Rostock T, Rustige J, Savelieva I, Schnabel R, Schotten U, Schwichtenberg L, Sinner MF, Steinbeck G, Stoll M, Tavazzi L, Themistoclakis S, Tse HF, Van Gelder IC, Vardas PE, Varpula T, Vincent A, Werring D, Willems S, Ziegler A, Lip GY, Camm AJ. A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference. Europace. 2015 Oct 18. pii: euv304. [Epub ahead of print] Review.

Schotten U, Hatem S, Ravens U, Jaïs P, Müller FU, Goette A, Rohr S, Antoons G, Pieske B, Scherr D, Oto A, Casadei B, Verheule S, Cartlidge D, Steinmeyer K, Götsche T, Dobrev D, Kockskämper J, Lendeckel U, Fabritz L, Kirchhof P, Camm AJ; EUTRAF investigators. The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results. Europace. 2015 Oct;17(10):1457-66. doi: 10.1093/europace/euv252. Epub 2015 Sep 12. Review.

Poulet C, Wettwer E, Grunnet M, Jespersen T, Fabritz L, Matschke K, Knaut M, Ravens U. Late Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial Fibrillation. PLoS One. 2015 Jun 29;10(6):e0131432. doi: 10.1371/journal.pone.0131432. eCollection 2015.

Zhang M, Schulte JS, Heinick A, Piccini I, Rao J, Quaranta R, Zeuschner D, Malan D, Kim KP, Röpke A, Sasse P, Araúzo-Bravo M, Seebohm G, Schöler H, Fabritz L, Kirchhof P, Müller FU, Greber B. Universal cardiac induction of human pluripotent stem cells in two and three-dimensional formats: implications for in vitro maturation. Stem Cells. 2015 May;33(5):1456-69. doi: 10.1002/stem.1964.

Kirchhof P, Tal T, Fabritz L, Klimas J, Nesher N, Schulte JS, Ehling P, Kanyshkova T, Budde T, Nikol S, Fortmueller L, Stallmeyer B, Müller FU, Schulze-Bahr E, Schmitz W, Zlotkin E, Kirchhefer U. First report on an inotropic peptide activating tetrodotoxin-sensitive, "neuronal" sodium currents in the heart. Circ Heart Fail. 2015 Jan;8(1):79-88. doi: 10.1161/CIRCHEARTFAILURE.113.001066. Epub 2014 Nov 25.

Fabritz L, Franz MR, Carmeliet E and Kirchhof P (2014) To the Editor-Propranolol, aβ-adrenoreceptor blocker, prevents arrhythmias also by its sodium channel blocking effect. Heart Rhythm11(3):e1

Yu TY, Syeda F, Holmes AP, Osborne B, Dehghani H, Brain KL, Kirchhof P and Fabritz L (2014) An automated system using spatial oversampling for optical mapping in murine atria. Development and validation with monophasic and transmembrane action potentials. Prog Biophys Mol Biol[Epub ahead of print]

Fabritz L and Kirchhof P (2013) Selective atrial profibrotic signalling in mice and man. Cardiovasc Res 99(4):592-4

Laakmann S, Fortmüller L, Piccini I, Grote-Wessels S, Schmitz W, Breves G, Kirchhof P and Fabritz L (2013) Minimally invasive closed-chest ultrasound-guided substance delivery into the pericardial space in mice.Naunyn Schmiedebergs Arch Pharmacol 386(3):227-38

Fabritz L, Fortmüller L, Yu TY, Paul M and Kirchhof P (2012) Can preload-reducing therapy prevent disease progression in arrhythmogenic right ventricular cardiomyopathy? Experimental evidence and concept for a clinical trial. Prog Biophys Mol Biol 110(2-3):340-6

Riley G, Syeda F, Kirchhof P and Fabritz L (2012) An introduction to murine models of atrial fibrillation. Front Physiol 3:296

Froese A, Breher SS, Waldeyer C, Schindler RFR, Nikolaev VO, Rinne S, Wischmeyer E, Schlueter J, Becher J, Simrick S, Vauti F, Kuhtz J, Meister P, Kreissl S, Torlopp A, Liebig SK, Laakmann S, Mueller TD, Neumann J, Stieber J, Ludwig A, Maier SK, Decher N, Arnold HH, Kirchhof P, Fabritz L* and Brand T* (2012) Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice. J Clin Invest122(3):1119-30

Fabritz L*, Hoogendijk M*, Scicluna BP, Van Amersfoorth SC, Fortmueller L, Wolf S, Laakmann S, Kreienkamp N, Piccini I, Breithardt G, Ruiz P, Witt H, Ebnet K, Wichter T, Levkau B, Franke WW, Pieperhoff S, de Bakker J, Coronel R and Kirchhof P (2011) Load-reducing therapy prevents development of arrhythmogenic right ventricular cardiomyopathy in plakoglobin-deficient mice. J Am Coll Cardiol 57(6):740-50

Blana A, Kaese S, Fortmüller L, Laakmann S, Damke D, van Bragt K, Eckstein J, Piccini I, Kirchhefer U, Nattel S, Breithardt G, Carmeliet P, Carmeliet E, Schotten U, Verheule S, Kirchhof P and Fabritz L (2010) Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability. Heart Rhythm 7(12):1862-9

Fabritz L, Damke D, Emmerich M, Kaufmann SG, Theis K, Blana A, Fortmüller L, Laakmann S, Hermann S, Aleynichenko E, Steinfurt J, Volkery D, Riemann B, Kirchhefer U, Franz MR, Breithardt G, Carmeliet E, Schäfers M, Maier SKG, Carmeliet P and Kirchhof P (2010) Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3. Cardiovascular Research 87(1):60-72

Wittköpper K, Fabritz L, Neef S, Ort KR, Grefe C, Unsöld B, Kirchhof P, Maier LS, Hasenfuss G, Dobrev D, Eschenhagen T and El-Armouche (2010) A Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging. J Clin Invest 120(2):617-26