Dr Siân Lax BSc (Hons), PhD

Dr Siân Lax

Institute of Cardiovascular Sciences
Post-doctoral Research Fellow

Contact details

Address
Institute of Cardiovascular Sciences
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Siân Lax is a post-doctoral research fellow working in Professor Steve Watson’s platelet Group. Her current project involves understanding the role of the platelet receptor CLEC-2 in regulating the severity of acute lung injury using in vivo models of lung inflammation and injury. Her previous post-doctoral work involved elucidating the in vivo role of hormones in lung injury and the role of mesenchymal stromal cells in lymphoid tissues following infection. Siân obtained her PhD from Birmingham University in 2004 where she researched the function of Rho-kinase II in regulated keratinocyte differentiation.

Qualifications

  • PhD in biochemistry
  • BSc (Hons) in molecular and cellular biochemistry

Publications

Parekh D, Patel J, Scott A, Lax S, Dancer RCA, D’Souza V, Greenwood H, Fraser WD, Gao F, Sapey E, Perkins GD, Thickett DR. (2017) Vitamin D deficiency in human and murine sepsis. Crit Care Med: 45:282-89

Hitchcock JR, Cook CN, Bobat S, Ross EA, Flores-Langarica A, Lowe KL, Khan M, Dominguez-Medina CC, Lax S, Carvalho-Gaspar M, Hubscher S, Rainger E, Cobbold M, Buckley CD, Mitchell T, Mitchell A, Jones ND, Van Rooijen N, Kirchhofer D, Henderson IR, Adams DH, Watson SW, Cunnigham AF. (2015) Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets. J Clin Invest; 125(12):4429-46

Dancer RCA, Parekh D, Lax S, D’Souza V, Zheng S, Bassford CR, Park D, Turner AM, Sapey E, Naidu B, Stewart PM, Fraser WD, Cooper MS, Gao F, Martineau A, Perkins GD, Thickett DR. (2015) Vitamin D deficiency contributes directly to acute lung injury. Thorax; 70:617-24

Lax S, Wilson MR, Takata M, Thickett DR. (2014) Using a non-invasive assessment of lung injury in a murine model of acute lung injury. BMJ Open Resp Res;1:e000014

Parekh D, Dancer R, Lax S, Cooper M, Martineau, Fraser W, Tucker O, Alderson D, Perkins GD, Gao-Smith F, Thickett DR. (2013) Vitamin D to prevent acute lung injury following oesophagectomy (VINDALOO) – a randomised placebo controlled trial. Trials, 14(1):100.

Ross EA, Coughlan RE, Flores-Langarica A, Lax S, Nicholson J, Desanti GE, Marshall JL, Bobat S, Hitchcock J, White A, Jenkinson WE, Khan M, Henderson IR, Lavery GG, Buckley CD, Anderson G, Cunningham AF. (2012) Thymic Function Is Maintained during Salmonella-Induced Atrophy and Recovery. J Immunol, 189:4266-74

Simonavicius N, Ashenden M, van Weverwijk A, Lax S, Huso DL, Buckley CD, Huijber IJ, Yarwood H, Isacke CM.(2012) Pericytes promote selective vessel regression to regulate vascular patterning. Blood, 120:1516-27

Lax S, Ross EA, White A, Marshall JL, Jenkinson WE, Isacke CM, Huso DL, Cunningham AF, Anderson G, Buckley CD. (2012) CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration. FEBS open bio, 2:187-90.