Dr Alexandra Mazharian obtained her PhD in 2007 in Blood cell Biology from the University Denis-Diderot, Paris 7, investigating the role of MAPKs in platelet activation. Her PhD thesis was under the supervision of Dr Marijke Bryckaert at the Cardiovascular Research centre of Lariboisiere in Paris. She then undertook postdoctoral training in the laboratory of Prof Steve Watson at the University of Birmingham, UK, investigating novel signalling mechanisms regulating megakaryocyte development, migration and platelet production. She also investigated the molecular basis of thrombocytopenia and haemorrhaging caused by the Src family kinase inhibitor Dasatinib, used in the treatment of chronic myeloid leukaemia. In 2011, Dr Mazharian joined the laboratory of Prof Yotis Senis as a postdoctoral fellow, at the University of Birmingham, UK, investigating the functional roles of the novel platelet ITIM-containing receptor G6b-B and the structurally-related protein-tyrosine phosphatases Shp1 and Shp2 in megakaryopoiesis. In 2013, Alexandra was awarded a British Heart Foundation Project Grant investigating the regulation of megakaryocyte and platelet hyperactivity and prothrombotic activity by the ITIM-containing collagen receptor LAIR-1 and PECAM-1. In 2015, Dr Mazharian was awarded a British Heart foundation Intermediate Basic Science Research Fellowship to investigate the regulation of the MAPKs Erk1/2 in platelets by the dual-specificity phosphatases (DUSP) 1 and 6 in megakaryopoiesis and platelet production.
Dr Mazharian has several peer-reviewed publications in leading scientific and biomedical research journals. She has written book chapters on megakaryocyte migration and signalling events regulating platelet production. She has been an invited speaker at national and international conferences on platelets and megakaryocytes.