Samantha has several years experience as a non-clinical cell biologist working primarily on human hematopoietic and endothelial cells. Throughout her career, she has investigated how the normal and pathological functions of cells are regulated by their biochemical, cellular and physical microenvironments.
She has returned to her roots in the cardiovascular sciences, recently joining the Fabritz/Kirchhof group, where she focuses on the molecular side of the group’s research with some links to clinical studies.
She previously worked within Prof Roy Bicknell’s research team. His group investigates (i) the location, targeting and possible function/s of tumour endothelial markers in specific cancers at the cellular/ molecular level. The ultimate aim of this research is to develop new or improved cancer treatments.
Her previous research focused on how alterations in endothelial behaviour mediate the underlying inflammatory processes which occur during development of chronic cardiovascular and renal diseases. She has utilised these cells predominantly in static and flow based adhesion assays to determine the molecular events governing adhesive interactions and affecting the development of chronic inflammatory diseases of the vasculature.
After entering the field of renal immunobiology, she supervised and/or mentored two PhD studentships. This small research group investigated the role of neutrophil derived proteases in vasculitis. This work was expanded to study cross-talk between glomerular cells and its role in vasculitis. As a part of this research, they explored deeper in the role of microenvironments in vasculitis, studying (i) endothelial-stromal interactions (ii) neutrophil and macrophage recruitment (iii) the lipid environment (lipid composition, antioxidants, signaling) and (iv) and the counter-play between these factors and neutrophil-derived proteases.
Two scientific papers were published from the renal study in:
- PLoS One (a 1st authorship), and
- Nephrology Dialysis Transplantation (a last authorship)
Before entering the renal field, her previous research focused on cardiovascular disease. This earlier period was even more productive as she set up or was directly involved in projects whose findings were published in the following journals: Atherosclerosis; Blood; Journal of Vascular Surgery; British Journal of Surgery; Annals of Clinical Biochemistry; International Journal of Experimental Pathology and Kidney International (impact factor 7.916, 6.968);
Most noteworthy papers include:
- Journal of Nutrition (impact factor 4.196, 5 year 4.686- joint first authorship)
- PLOS biology (impact factor 12.690, 5 year 13.447- first authorship)
- Circulation Research (5yr Impact Factor= 9.857 - first authorship)