Dr Siân Lax BSc (Hons), PhD

 

Research Fellow

Cardiovascular and Respiratory Sciences

Lax,Sian-Cropped-110x146

Contact details

School of Clinical and Experimental Medicine
Centre for Translational Inflammation Research
University of Birmingham Research Laboratories
Queen Elizabeth Hospital
Mindelsohn Way
Birmingham, B15 2WB

About

Siân Lax is a post-doctoral research fellow working in Doctor David Thickett’s Lung Injury Group. Her current project involves understanding the role of glucocorticoids and Vitamin D in the severity and persistence of acute lung injury (ALI) using in vivo models of lung inflammation and injury. Her previous post-doctoral work involved elucidating the in vivo role of mesenchymal stromal cells in lymphoid tissues following infection. Siân obtained her PhD from Birmingham University in 2005 where she researched the function of Rho-kinase II in regulated keratinocyte differentiation.

Qualifications

  • PhD in biochemistry
  • BSc (Hons) in molecular and cellular biochemistry

Publications

Hardie DL, Baldwin MJ, Naylor A, Haworth OJ, Hou TZ, Lax S, Curnow SJ, Willcox N, MacFadyen J, Isacke CM, Buckley CD. (2011) The stromal cell antigen CD248 (endosialin) is expressed on naive CD8+ human T cells and regulates proliferation. Immunology, 133:288-95.

Lax S, Hardie DL, Wilson A, Douglas MR, Anderson G, Huso D, Isacke CM, Buckley CD. (2010) The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion. Eur J Immunol, 40:11884-9

Ross EA, Freeman S, Zhao Y, Dhanjal TS, Ross EJ, Lax S, Ahmed Z, Hou TZ, Kalia N, Egginton S, Nash G, Watson SP, Frampton J, Buckley CD. (2008) A novel role for PECAM-1 (CD31) in regulating haematopoietic progenitor cell compartmentalization between the peripheral blood and bone marrow. PLoS One, 3:e2338

Flavell SJ, Hou TZ, Lax S, Filer AD, Salmon M, Buckley CD. (2008) Fibroblasts as novel therapeutic targets in chronic inflammation. Br J Pharmacol, 153:S241-6

Parsonage G, Filer A, Bik M, Hardie D, Lax S, Howlett K, Church LD, Raza K, Wong SH, Trebilcock E, Scheel-Toellner D, Salmon M, Lord JM, Buckley CD.(2008) Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha. Arthritis Res Ther, 10:R47

Lax S, Hou TZ, Jenkinson E, Salmon M, MacFadyen JR, Isacke CM, Anderson G, Cunningham AF, Buckley CD. (2007) CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair. FEBS Lett, 581:3550-6

McMullan R, Lax S, Robertson VH, Radford DJ, Broad S, Watt FM, Rowles A, Croft DR, Olson MF, Hotchin NA. (2003) Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway. Curr Biol, 13:2185-9

Dawson J, Hotchin N, Lax S, Rumsby M. (2003) Lysophosphatidic acid induces process retraction in CG-4 line oligodendrocytes and oligodendrocyte precursor cells but not in differentiated oligodendrocytes. J Neurochem, 87:947-5

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