Dr Melanie Madhani graduated from the University of Wales College Of Medicine in 1998 with a BSc (Hons) in Pharmacology. She obtained a PhD in Cardiovascular Sciences from the Ivy League School, Dartmouth College, New Hampshire, USA and University of Wales in 2002. She then joined University College London (UCL) as a post-doctoral research fellow, to work under Dr. Adrian Hobbs. Here, she investigated the role of cGMP in cardiovascular diseases. During her time at UCL, she was awarded a UCL Bogue Fellowship to work with Nobel Laureate Dr Louis Ignarro, University of California, Los Angeles, USA. In 2005, she joined Dr. Philip Eaton's research group at The Rayne Institute, King's College London, where she broadened her experience in cardiac physiology in order to complement her vascular knowledge and skills into cGMP regulation during myocardial ischaemia reperfusion injury. In 2009, Dr. Madhani was appointed as a Lecturer in Cardiovascular Medicine at the University of Birmingham. Currently, Melanie collaborates with Prof Frenneaux (University of Aberdeen), Prof Horowitz (Queen Elizabeth Hospital, University of Adelaide, Australia), and Prof Bonser (Queen Elizabeth Hospital, University of Birmingham). Melanie is currently an associate editor for Pharmacology and Therapeutics and Bulletin Editor for the British Society for Cardiovascular Research.
Madhani M, Hall AR, Cuello F, Burgoyne JR, Fuller W, Hobbs AJ, Shattock MJ & Eaton P. Ser-69 phosphorylation of phospholemman contributes to Sildenafil-induced cardioprotection against reperfusion injury. Am J Physio Heart 2010; June 11
Baliga RS, Zhao L, Madhani M, Lopez-Torondel B, Visintin C, Selwood D, Wilkins MR, MacAllister RJ, Hobbs AJ. (2008) Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension. Am J Respir Crit Care Med.15;178:861-9.
Burgoyne J, Madhani M, Cuello F, Brennan JP, Charles R L, Browning D and Eaton P. (2007) Interprotein disulfide bond formation activates PKGI independently of cGMP. Science, 317:1393-7.
Villar IC, Panayiotou CM, Sheraz A, Madhani M, Scotland RS, Nobles M, Kemp-Harper B, Ahluwalia A and Hobbs AJ. (2007) Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor Cardiovasc Res 74:515-25.
Leiper J, Nandi M, Torondel B, Murray-Rust J, Malaki M, O'hara B, Rossiter S, Anthony S, Madhani M, Selwood D, Smith C, Wojciak-Stohard B, Rudiger A, Stidwell R, McDonald N Q, Vallance P. (2007) Disruption of methylarginine metabolism impairs vascular homeostasis.Nat Med ;13:198-203.