Thin Luu originally trained as a Pharmacologist and is interested in inflammation and atherosclerosis. She is an expert in setting up complex mono- and multi-cellular models of cell culture in understanding the processes of cell adhesion and migration, and the effects of blood flow on these processes, by application of well-defined, quantitative, in vitro models.
Thin is a member of British Microcirculation Society and British Cardiovascular Society.
Thin did her PhD at Harefield Hospital under the supervision of Professor Sir. Magdi Yacoub. As one of his first PhD students she demonstrated that arterial vessels used for bypass had greater vasodilatation than saphenous vein in response to acetylcholine/ substance P, which may explain why arterial bypass has better patency when arterial rather than venous grafts are used. The differential response between arteries and veins was due to their endothelial cell function, vessel structure, and also receptor localisation.
The intriguing results led her to take different approaches in studying how each component of a blood vessel wall (smooth muscle cells and endothelial cells) behaved in culture. she joined the cardiovascular rheology group led by Professor Gerard Nash, which specialises in using flow-based models to study molecular mechanisms of leukocyte recruitment through endothelium in specific tissues. Here, she developed an interest in the molecular control of leukocyte adhesion and migration through the endothelium, and how disruption of these processes occurs in vascular inflammatory diseases. Thin has special skills in setting up complex mono- and multi-cellular models using isolated primary endothelial cells from human umbilical cords, mouse hearts and lungs, with leukocytes and/or stem cells. She has adapted a number of new molecular approaches to study the molecular control of leukocyte adhesion and migration through the endothelium, and how disruption of these processes occurs in vascular inflammatory diseases.
At the present Thin is taking day-to-day lead in a new collaborative project on investigating the immunomodulatory effect of mesenchymal stem cells between Gerard Nash, Jon Frampton (Professor in Molecular Stem Cell Biology), Chris Buckley (Professor in Rheumatoid Arthritis), Phil Newsome (Professor in Liver Transplant Unit) & Ed Rainger (Reader in Inflammation), funded by BHF and started last year. She has developed new culture models which is a new initiative requiring advanced culture skill for multi-cellular models using primary human cells. It also requires incorporation of co-cultures into flow models of leukocyte recruitment.
NT. Luu, Madden J, Calder PC, Grimble RF, Shearman CP, Chan T, Dastur N, Rainger GE, Nash GB. Dietary supplementation with fish oil modifies the ability of human monocytes to induce an inflammatory response. J of Nutrition. 137:1-6, 2007
Mura M, Swain RK, Zhuang X, Vorschmitt H, Reynolds G, Durant S, Beesley JF, Herbert JM, Sheldon H, Andre M, Sanderson S, Glen K, Luu NT, McGettrick HM, Antczak P, Falciani F, Nash GB, Nagy ZS, Bicknell R. Identification and angiogenic role of the novel tumor endothelial marker CLEC14A. Oncogene. 2011 Jun 27
NT. Luu, Madden J, Calder PC, Grimble RF, Shearman CP, Chan T, Rainger GE, Nash GB. Comparison of the pro-inflammatory potential of monocytes from healthy adults and those with peripheral vascular disease using an in vitro culture model. Atherosclerosis. 193, 235-468, 2006
Luu NT. Rainger GE. Buckley CD. Nash GB. Cd31 regulates direction and rate of neutrophil migration over and under endothelial cells. Journal of Vascular Research. 40:467-479, 2003.
Radford DJ. Luu NT. Hewins P. Nash GB. Savage CO. Anti-neutrophil cytoplasmic antibodies stabilise adhesion and promote migration of flowing neutrophils on endothelial cells. Arthritis & Rheumatism. 44:2851-61, 2001 Dec.
Luu NT. Rainger GE. Nash GB. Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils. Journal of Immunology. 164:5961-9, 2000 Jun 1
Luu NT. Dashwood MR. Chester AH. Tadjkarimi S. Yacoub MH. Action of vasoactive intestinal peptide and distribution of its binding sites in vessels used for coronary artery bypass grafts. American Journal of Cardiology. 71:1278-82, 1993 Jun 1.
Luu NT. Chester AH. O'Neil GS. Tadjkarimi S. Pepper JR. Yacoub MH. Different responses of the human gastroepiploic and internal mammary arteries to vasoactive peptides. American Journal of Physiology. 264:H583-7, 1993 Feb.