Cardiovascular Research, Respiratory Health
David runs the lung injury and fibrosis treatment (LIFT) reseach programme. His research centres around inflammatory lung diseases especially acute lung injury, interstitial lung disease and recently COPD. He has a basic science interest in the role of growth factors e.g. VEGF in lung epithelial repair as well as the relationship between infection and inflammation in acute lung injury / ILD. He has clinical trials experience in asthma, COPD, idiopathic pulmonary fibrosis and acute lung injury. He is a steering group member for NIHR BALTI-prevention and ASEPSIS. He currently has funding from the Wellcome Trust, and the Intensive care society.
Richter, A.G., S. McKeown, S. Rathinam, L. Harper, P. Rajesh, D.F. McAuley, R. Heljasvaara, and D.R. Thickett,2009 'Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosi's. Thorax. 64(2): p. 156-61.
McKeown, S., A.G. Richter, C. O'Kane, D.F. McAuley, and D.R. Thickett,2009 'MMP expression and abnormal lung permeability are important determinants of outcome in IPF'. Eur Respir J. 33(1): p. 77-84.
Shyamsundar, M., S.T. McKeown, C.M. O'Kane, T.R. Craig, V. Brown, D.R. Thickett, M.A. Matthay, C. Taggart, J.T. Backman, J.S. Elborn, and D.F. McAuley,2009 'Simvastatin Decreases Lipopolysaccharide Induced Pulmonary Inflammation in Healthy Volunteers'. Am J Respir Crit Care Med.
O'Kane, C.M., S.W. McKeown, G.D. Perkins, C.R. Bassford, F. Gao, D.R. Thickett, and D.F. McAuley,2009 'Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome'. Crit Care Med. 37(7): p. 2242-9.
Richter, A.G., R.A. Stockley, L. Harper, and D.R. Thickett,2009 'Pulmonary infection in Wegener granulomatosis and idiopathic pulmonary fibrosis'. Thorax. 64(8): p. 692-7.
Perkins, G.D., N. Nathani, A.G. Richter, D. Park, M. Shyamsundar, R. Heljasvaara, T. Pihlajaniemi, M. Manji, W. Tunnicliffe, D. McAuley, F. Gao, and D.R. Thickett,2009 'Type XVIII collagen degradation products in acute lung injury'. Crit Care. 13(2): p. R52.
Gao, F., L. Linhartova, A.M. Johnston, and D.R. Thickett,2008 'Statins and sepsis'. Br J Anaesth. 100(3): p. 288-98.
Perkins, G.D., F. Gao, and D.R. Thickett,2008 'In vivo and in vitro effects of salbutamol on alveolar epithelial repair in acute lung injury'. Thorax. 63(3): p. 215-20.