Recent publications
Article
Jasper, A, Faniyi, A, Davis, L, Grudzinska, F, Halston, R, Hazeldine, J, Parekh, D, Sapey, E, Thickett, D & Scott, A 2024, 'E-cigarette vapor renders neutrophils dysfunctional due to filamentous actin accumulation', Journal of Investigational Allergology and Clinical Immunology, vol. 153, no. 1, pp. 320-329.e8. https://doi.org/10.1016/j.jaci.2023.08.025
Patel, A, Caruana, EJ, Hodson, J, Morrison, R, Khor, B, Gysling, S, Trevis, J, Mangel, T, Benson, R, Zakeri, R, Manders, J, Vaja, R, Rogers, L, Baker, P, Pournaras, DJ, Thickett, D, Hewison, M, Naidu, B & Lim, E 2024, 'Role of vitamin D supplementation in modifying outcomes after surgery: a systematic review of randomised controlled trials', BMJ open, vol. 14, no. 1, e073431. https://doi.org/10.1136/bmjopen-2023-073431
Quarton, S, McGee, K, Cumley, N, Behruznia, M, Jeff, C, Belchamber, K, Cox, M, Thickett, D, Scott, A, Parekh, D, McNally, A & Sapey, E 2024, 'Towards personalised anti-microbial and immune approaches to infections in acute care. Can real-time genomic-informed diagnosis of pathogens, and immune-focused therapies improve outcomes for patients? An observational, experimental study protocol', PLoS ONE, vol. 19, no. 3, e0298425. https://doi.org/10.1371/journal.pone.0298425
Mahida, RY, Lax, S, Bassford, CR, Scott, A, Parekh, D, Hardy, RS, Naidu, B, Matthay, MA, Stewart, PM, Cooper, MC, Perkins, GD & Thickett, DR 2023, 'Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS', Frontiers in immunology, vol. 14, 1159831. https://doi.org/10.3389/fimmu.2023.1159831
Grudzinska, FS, Faniyi, AA, Scott, A, Sapey, E & Thickett, DR 2023, 'Observational cohort study protocol: neutrophil function and energetics in adults with pneumonia and sepsis: Pneumonia Metabolism in Ageing (PUMA)', BMJ Open Respiratory Research, vol. 10, no. 1, e001806. https://doi.org/10.1136/bmjresp-2023-001806
Thein, OS, Ali, NA, Mahida, RY, Dancer, RCA, Ostermann, M, Amrein, K, Martucci, G, Scott, A, Thickett, DR & Parekh, D 2023, 'Raised FGF23 Correlates to Increased Mortality in Critical Illness, Independent of Vitamin D', Biology, vol. 12, no. 2, 309. https://doi.org/10.3390/biology12020309
Grudzinska, F, Jasper, A, Sapey, E, Thickett, D, Mauro, C, Scott, A & Barlow, J 2023, 'Real-time assessment of neutrophil metabolism and oxidative burst using extracellular flux analysis', Frontiers in immunology, vol. 14, 1083072. https://doi.org/10.3389/fimmu.2023.1083072
PHOSP-COVID study collaborative group 2023, 'Residual Lung Abnormalities after COVID-19 Hospitalization Interim Analysis of the UKILD Post-COVID-19 Study', American Journal of Respiratory and Critical Care Medicine, vol. 207, no. 6, pp. 693-703. https://doi.org/10.1164/rccm.202203-0564OC
Ahmad, S, Wrennall, JA, Goriounova, AS, Sekhri, M, Iskarpatyoti, JA, Ghosh, A, Abdelwahab, SH, Voeller, A, Rai, M, Mahida, RY, Krajewski, K, Ignar, DM, Greenbaum, A, Moran, TP, Tilley, SL, Thickett, DR, Sassano, MF & Tarran, R 2023, 'Specific Inhibition of Orai1-mediated Calcium Signalling Resolves Inflammation and Clears Bacteria in an ARDS Model', American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.202308-1393OC
Mahida, RY, Price, J, Lugg, ST, Li, H, Parekh, D, Scott, A, Harrison, P, Matthay, MA & Thickett, DR 2022, 'CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome', American journal of physiology. Lung cellular and molecular physiology, vol. 322, no. 4, pp. L617-L624. https://doi.org/10.1152/ajplung.00052.2022
Belchamber, KBR, Thein, OS, Hazeldine, J, Grudzinska, FS, Faniyi, A, Hughes, M, Jasper, A, Yip, KP, Crowley, LE, Lugg, ST, Sapey, E, Parekh, D, Thickett, DR & Scott, A 2022, 'Dysregulated neutrophil phenotype and function in hospitalised non-ICU COVID-19 pneumonia', Cells, vol. 11, no. 18, 2901. https://doi.org/10.3390/cells11182901
CATALYST investigators, Fisher, B, Veenith, T, Slade, D, Gaskell, C, Rowland, M, Whitehouse, T, Scriven, J, Parekh, D, Balasubramaniam, M, Cooke, G, Morley, N, Gabriel, Z, Wise, M, Porter, J, McShane, H, Ho, L-P, Newsome, P, Rowe, A, Sharpe, R, Thickett, D, Bion, J, Gates, S, Richards, D, Kearns, P & Mussai, F 2022, 'Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial', The Lancet Respiratory Medicine, vol. 10, no. 3, pp. 255-266. https://doi.org/10.1016/S2213-2600(21)00460-4, https://doi.org/10.1016/s2213-2600(21)00460-4
Ahmed, A, Alderazi, SA, Aslam, R, Barkat, B, Barker, BL, Bhat, R, Cassidy, S, Crowley, LE, Dosanjh, DP, Ebrahim, H, Elndari, N, Gardiner, C, Gogokhia, A, Grudzinska, FS, Gurung, MT, Hughes, T, Ismail, I, Iredale, N, Irshad, S, Johnson, S, Kavanagh, D, Knight, T, Livesey, A, Lugg, ST, Marathe, M, Mcdougall, A, Nawaz, W, Nettleton, K, O’flynn, L, Okoth, K, Parekh, D, Perry, R, Pudney, EJ, Sadiq, A, Soge, O, Soloman, R, Soltan, M, Strecker, M, Thein, OS, Thickett, D, Thomas, A & Thornton, R 2022, 'Utility of severity assessment tools in COVID-19 pneumonia: a multicentre observational study', Clinical Medicine, vol. 22, no. 1, pp. 63-70. https://doi.org/10.7861/clinmed.2020-1107
Lugg, ST, Mackay, WR, Faniyi, AA, Faustini, SE, Webster, C, Duffy, JE, Hewison, M, Shields, AM, Parekh, D, Richter, AG, Scott, A & Thickett, DR 2022, 'Vitamin D status: a U-shaped relationship for SARS-CoV-2 seropositivity in UK healthcare workers', BMJ Open Respiratory Research, vol. 9, no. 1, e001258. https://doi.org/10.1136/bmjresp-2022-001258
Review article
Davis, LC, Sapey, E, Thickett, DR & Scott, A 2022, 'Predicting the pulmonary effects of long-term e-cigarette use: are the clouds clearing?', European Respiratory Review, vol. 31, no. 163, 210121. https://doi.org/10.1183/16000617.0121-2021
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