Dr Tull is Research Fellow in the College of Medical and Dental Sciences.
Samantha has published 14 research papers in peer reviewed journals in the fields of cardiovascular and renal inflammatory disease. These include one last author and four first author publications.
PGCert in Academic Practice (PCAP) – FLTHE - 2014 (pass with merit)
University of Birmingham
Ph.D. in Cardiovascular Sciences 2004, University of Leicester
Thesis: Changes to endothelial cell function induced by oxidative stress; a model of cell senescence.
M.Sc. in Experimental & Molecular Pathology 1994, University of Dundee
Thesis: The effect of copper on endothelial cell proliferation and cell cycle distribution.
B.Sc. Hons. (2.1) in Bio-analytical Science 1992, Kingston University
Thesis: Effects of dietary carbohydrate on blood glucose levels in Carp and Tilapia.
Dr Samantha Tull is a tutor for the integrated problem solving (IPAS) course for both 1st and 2nd year medical students. She also participates in the annual research taster program (which has now been incorporated into IPAS). This involves small group teaching to give 1st year medical students (i) access to lab-based research and (ii) an opportunity to analyse and critique papers in a journal club setting.
She recently passed with merit the 2014 PCAP –FLTHE course after producing with a short thesis, based on her teaching.
Samantha has several years experience as a non-clinical cell biologist working primarily on human hematopoietic and endothelial cells. Throughout her career, she has investigated how the normal and pathological functions of cells are regulated by their biochemical, cellular and physical microenvironments.
She has returned to her roots in the cardiovascular sciences, recently joining the Fabritz/Kirchhof group, where she focuses on the molecular side of the group’s research with some links to clinical studies.
She previously worked within Prof Roy Bicknell’s research team. His group investigates (i) the location, targeting and possible function/s of tumour endothelial markers in specific cancers at the cellular/ molecular level. The ultimate aim of this research is to develop new or improved cancer treatments.
Her previous research focused on how alterations in endothelial behaviour mediate the underlying inflammatory processes which occur during development of chronic cardiovascular and renal diseases. She has utilised these cells predominantly in static and flow based adhesion assays to determine the molecular events governing adhesive interactions and affecting the development of chronic inflammatory diseases of the vasculature.
After entering the field of renal immunobiology, she supervised and/or mentored two PhD studentships. This small research group investigated the role of neutrophil derived proteases in vasculitis. This work was expanded to study cross-talk between glomerular cells and its role in vasculitis. As a part of this research, they explored deeper in the role of microenvironments in vasculitis, studying (i) endothelial-stromal interactions (ii) neutrophil and macrophage recruitment (iii) the lipid environment (lipid composition, antioxidants, signaling) and (iv) and the counter-play between these factors and neutrophil-derived proteases.
Two scientific papers were published from the renal study in:
PLoS One (a 1st authorship), and
Nephrology Dialysis Transplantation (a last authorship)
Before entering the renal field, her previous research focused on cardiovascular disease. This earlier period was even more productive as she set up or was directly involved in projects whose findings were published in the following journals: Atherosclerosis; Blood; Journal of Vascular Surgery; British Journal of Surgery; Annals of Clinical Biochemistry; International Journal of Experimental Pathology and Kidney International (impact factor 7.916, 6.968);
Most noteworthy papers include:
Journal of Nutrition (impact factor 4.196, 5 year 4.686- joint first authorship)
PLOS biology (impact factor 12.690, 5 year 13.447- first authorship)
Circulation Research (5yr Impact Factor= 9.857 - first authorship)
Kuravi SJ, Bevins A (jointed first), Satchell SC, Harper L, Williams JM, Rainger GE, Savage CO and Tull SP (2012) Neutrophil serine proteases mediate inflammatory cell recruitment by glomerular endothelium and progression towards dysfunction. Nephrol Dial Transplant 27(12):4331-8
Tull SP, Bevins A, Kuravi SJ, Satchell SC, Al-Ani B, Young SP, Harper L, Williams JM, Rainger GE, Savage CO (2012) PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells. PLoS One 7(8):e43916
Yates CM, Tull SP (jointed first), Madden J, Calder PC, Grimble RF, Nash GB and Rainger GE (2011) Docosahexaenoic acid (DHA), inhibits the adhesion of flowing neutrophils to cytokine stimulated human umbilical vein endothelial cells. J Nutr 141(7):1331-4
Tull SP, Yates CM, Maskrey BH, O'Donnell VB, Madden J, Grimble RF, Calder PC, Nash GB and Rainger GE (2009) Omega-3 Fatty Acids and Inflammation: Novel Interactions Reveal a New Step in Neutrophil Recruitment. PLoS Biol 7(8):e1000177
Luu NT, Madden J, Calder PC, Grimble RF, Shearman CP, Chan T, Tull SP, Dastur N, Rainger GE and Nash GB (2007) Comparison of the pro-inflammatory potential of monocytes from healthy adults and those with peripheral arterial disease using an in vitro culture model. Atherosclerosis 193(2):259-68
Tull SP, Anderson SI, Hughan SC, Watson SP, Nash GB and Rainger GE (2006) Cellular Pathology of Atherosclerosis: Smooth Muscle Cells Promote Adhesion of Platelets to Cocultured Endothelial Cells. Circ Res 98(1):98-104
Hayes PD, Tull S, Hayes NJ, Goodall AH, Thompson MM, Bell PRF, London NJM and Naylor AR (2005) Thromboembolic events after carotid endarterectomy are associated with the HPA-3 platelet receptor polymorphism. British Journal of surgery 92(4) 507-8
Williams JC, Fotherby MD, Forster LA, Tull SP and Ferns GA (2000) Mononuclear cell adhesion to collagen ex vivo is related to pulse pressure in elderly subjects. Atherosclerosis 151(2):463-9