Wiebke is interested in disorders of the adrenal and the gonads, with a specific focus on sex steroids and the regulation of their metabolism and action. Her group has identified human mutations in co-factor generating enzymes playing a crucial role in steroidogenesis, PAPS synthase and P450 oxidoreductase, and are interested in their role in the pathophysiology of androgen excess and androgen deficiency.
A major focus of the work addresses the role of mass spectrometry in steroid analysis including its use as a discovery tool in adrenal and gonadal disorders and in the diagnosis and monitoring of steroid-producing and steroid-dependent tumours.
Wiebke Arlt’s research group is supported by the Medical Research Council, the Wellcome Trust, the European Commission (FP7 Health, Marie Curie), the European Science Foundation, the European Society of Paediatric Endocrinology, the Society for Endocrinology and the Birmingham Children’s Hospital Research Foundation.
Idkowiak J, O’Riordan S, Reisch N, Malunowicz EM, Collins F, Kerstens MN, Koehler B, Graul-Neumann LM, Szarras-Czapnik M, Silink M, Dattani MT, Shackleton CHL, Maiter D, Krone N, Arlt W. (2010) Pubertal presentation in seven patients with congenital adrenal hyperplasia due to P450 oxidoreductase deficiency.J Clin Endocrinol Metab Dec 29 [epub ahead of print]
Arlt W, Willis DS, Wild SH, Krone N, Doherty EJ, Hahner S, Han TS, Carroll PV, Conway GS, Rees DA, Stimson RH, Walker BR, Connell JMC, Ross RJ. (2010) Health status of adults with congenital adrenal hyperplasia: a cohort study by the United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE). J Clin Endocrinol Metab, 95(11): 5110-21.
Radford DJ, Wang K, McNelis JC, Taylor AE, Hechenberger G, Hofmann J, Chahal H, Arlt W, Lord JM. (2010) Dehydropeiandrosterone sulphate directly activates protein kinse C-β to increase human neutrophil superoxide generation. Mol Endocrinol, 24(4): 813-21.
Noordam C*, Dhir V*, McNelis JC, Schlereth F, Hanley NA, Krone N, Smeitink JA, Smeets R, Sweep FC, Claahsen-van der Grinten HL, Arlt W. (2009) Inactivating PAPSS2 mutations in a patient with premature pubarche. N Engl J Med, 360(22): 2310-2318. *These authors contributed equally
Debono M, Ghobadi C, Rostami-Hodjegan A, Huatan H, Campbell M, Newell-Price J, Darzy K, Merke D, Arlt W, Ross RJ. (2009) Modified-release hydrocortisone to provide circadian cortisol profiles. J Clin Endocrinol Metab, 94(5): 1548-1554.
Dhir V, Ivison HE, Krone N, Shackleton CHL, Doherty AE, Stewart PM, Arlt W. (2007) Differential inhibition of CYP17A1 and CYP21A2 activities by the P450 oxidoreductase mutant A287P. Mol Endocrinol, 21:1958-1968.
Hammer F, Subtil S, Lux P, Maser-GluthC, Stewart PM, Allolio B, Arlt W. (2005) No evidence for hepatic conversion of dehydroepiandrosterone sulfate (DHEAS) to DHEA – in vivo and in vitro studies. J Clin Endocrinol Metab, 90: 3600-3605.
Arlt W, Walker EA, Draper N, Ivison HE, Ride JP, Hammer F, Chalder SM, Borucka M, Hauffa BP, Malunowicz EM, Stewart PM, Shackleton CHL. (2004) Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study. Lancet, 363: 2128-2135.