Dr Ana Maria Gonzalez

 

Senior Lecturer in Neuroscience and College Enhancement Educational Fellow

Neurotrauma and Neurodegeneration

Gonzalez,Ana2-Cropped-110x146

Contact details

Room WX2.19, Institute of Biomedical Research (West)
School of Clinical and Experimental Medicine
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

About

Ana Maria Gonzalez is a Senior Lecturer in Neuroscience and  College Educational Enhancement Fellow

Qualifications

  • Ph.D. (Biology, Cum Laude), Universidad Autónoma de Madrid, Spain, 1991
  • B.S. (Biology), Universidad de los Andes, Bogotá, Colombia, 1982
  • Associate of the Higher Education Academy, University of Birmingham, 2011

Biography

Ana Maria Gonzalez is a Senior Lecturer in the Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences. She received her BSc degree in Biology from Universidad de Los Andes in Bogota, Colombia in 1981. 

After working for 3 years as a research fellow in Hospital Ramon y Cajal in Madrid, Spain, she moved to the US where she worked in the Laboratories for Neuroendocrinology at the Salk and Scripps Institutes in La Jolla, California. In 1991 she obtained her PhD from Universidad Autonoma de Madrid. She went back to California and in 1995 joined "Selective Genetics" - a biotechnology company in San Diego where she worked as a Senior Scientist for 6 years.

In 2001 she moved to London and was appointed Senior Lecturer in the Division of Physiology, School of Biomedical Sciences at King's College London. In 2004, she joined the University of Birmingham as a Senior Lecturer. 

Teaching

  • Module Coordinator of “Neutrauma: Neurodegeneration and Regeneration”, a third year elective Module in the Medical Sciences Programme
  • Delivery of lectures and SGT in years 1, 2 and 3 of Medical Sciences Programme
  • Delivery of Learning Skills Sessions for year 1 MBChB students
  • Personal mentor MBChB students
  • Personal mentor for PhD students and Research Fellows
  • Supervision of 2nd year Medical Sciences students during Summer Laboratory Studentships
  • Internal Supervisor for Elective Studies for 4th year MBChB students

Postgraduate supervision

Supervision of undergraduate and higher degrees in research PhD, MRes, MSc

Research

Dr Ana Maria Gonzalez is a member of various Research Groups within theNeurotrauma and Neurodegeneration Section. One of her main research interests is in Neuroendocrine control of CNS homeostasis.

Braindamage due to CNS trauma is one of the leading causes of morbidity andmortality in the world.  CNS injury canhave severe systemic and CNS sequelae including cerebral salt wasting, brainoedema, subarachnoid and ventricular haemorrhage, hydrocephalus and post-traumaticventricular enlargement.

Cerebrospinalfluid (CSF) bathes the brain and spinal cord and is vital for the maintenanceof fluid homeostasis within the central nervous system. The production of CSFby the choroid plexus is tightly regulated providing the necessary nutrientsand removing any waste which may compromise the normal homeostasis of thecentral nervous system. Some of the molecules produced and secreted by thechoroid plexus include growth factors and neuropeptide hormones (i.e.fibroblast growth factors, transforming growth factors, aquaporins, etc) knownplay critical roles in CNS homeostasis. 

CSF Disorders Research Page.

Other activities

  • Member of the Learning and Teaching Committee, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham UK
  • Member of the eLearning Committee, College of Medical and Dental Sciences, University of Birmingham UK
  • Member of the Neurotrauma and Neurodegeneration Postgraduate Research Students Review, School of Clinical and Experimental Medicine, University of Birmingham UK
  • Deputy coordinator Pharmaceutical Enterprise Module (Masters Programme, School of Pharmacy), College of Medical and Dental Sciences, University of Birmingham UK
  • Coordinator of the Histology and Microscopy Facilities for Integrative Physiology, School of Clinical and Experimental Medicine, University of Birmingham UK
  • Member of the Health and Safety Committee for the School of Clinical and Experimental Medicine, University of Birmingham UK
  • Member of the Programme Committee for the Centre for Learning and Academic Development (CLAD), University of Birmingham

Awards:
Dr Gonzalez has received a 2013 Summer Studentship Award from the Society for Endocrinology (http://www.endocrinology.org)

Society-For-Endocrinology

Publications

Gonzalez AM, Berlanga O, Leadbeater WE, Cooper-Charles L, Sims K, Logan A, Eliceiri B, Berry M, Baird A (2009) The deployment of adenovirus-containing gene activated matrices onto severed axons after central nervous system injury leads to transgene expression in target neuronal cell bodies. The journal of gene medicine 11:679-688

Gonzalez AM, Taylor WM, Johanson CE, King JC, Leadbeater WE, Stopa EG, Baird A (2010) Co-localization and regulation of basic fibroblast growth factor and arginine vasopressin in neuroendocrine cells of the rat and human brain. Cerebrospinal Fluid Res 7:13

Gonzalez AM, Leadbeater W, Podvin S, Borboa A, Burg M, Sawada R, Rayner J, Sims K, Terasaki T, Johanson C, Stopa E, Eliceiri B and Baird A (2010) Epidermal growth factor targeting of bacteriophage to the choroid plexus for gene delivery to the central nervous system via cerebrospinal fluid. Brain Res 1359:1-13

Gonzalez AM, Taylor WM, Johanson CE, King JC, Leadbeater WE, Stopa EG and Baird A (2010) Co-localization and regulation of basic fibroblast growth factor and arginine vasopressin in neuroendocrine cells of the rat and human brain. Cerebrospinal Fluid Res 7:13

Baird A, Eliceiri BP, Gonzalez AM, Johanson CE, Leadbeater W and Stopa EG (2011) Targeting the choroid plexus-CSF-brain nexus using peptides identified by phage display. Methods Mol Biol 686:483-498

Chan SY, Martin-Santos A, Loubiere LS, Gonzalez AM, Stieger B, Logan A, McCabe CJ, Franklyn JA and Kilby MD (2011) The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation. J Physiol 589(Pt 11):2827-2845

Eliceiri BP, Gonzalez AM and Baird A (2011) Zebrafish model of the blood-brain barrier: morphological and permeability studies. Methods Mol Biol 686:371-378

Gonzalez AM, Leadbeater WE, Burg M, Sims K, Terasaki T, Johanson CE, Stopa EG, Eliceiri BP and Baird A (2011) Targeting choroid plexus epithelia and ventricular ependyma for drug delivery to the central nervous system. BMC Neurosci 12:4

Gonzalez AM, Podvin S, Lin SY, Miller MC, Botfield H, Leadbeater WE, Roberton A, Dang X, Knowling SE, Cardenas-Galindo E, Donahue JE, Stopa EG, Johanson CE, Coimbra R, Eliceiri BP and Baird A (2011) Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury. Fluids Barriers CNS 8(1):6

Podvin S, Gonzalez AM, Miller MC, Dang X, Botfield H, Donahue JE, Kurabi A, Boissaud-Cooke M, Rossi R, Leadbeater WE, Johanson CE, Coimbra R, Stopa EG, Eliceiri BP and Baird A (2011) Esophageal cancer related gene-4 is a choroid plexus-derived injury response gene: evidence for a biphasic response in early and late brain injury. PLoS One 6(9):e24609

Sawada R, Peterson CY, Gonzalez AM, Potenza BM, Mueller B, Coimbra R, Eliceiri BP and Baird A (2011) A phage-targeting strategy for the design of spatiotemporal drug delivery from grafted matrices. Fibrogenesis Tissue Repair 4:7

Susarla R, Gonzalez AM, Watkinson JC and Eggo MC (2011) Expression of receptors for VEGFS on normal human thyroid follicular cells and their role in follicle formation. J Cell Physiol 227(5):1992-2002

Johanson CE, Gonzalez AM, Miller M, Podvin S, Stopa E and Baird A (2013) Augurin in choroid plexus-cerebrospinal fluid: Implications for subependymal neurogenesis. In The Handbook of Biologically Active Peptides, 2nd edition, A. Kastin, ed., Elsevier Press, 2013.

Botfield H, Gonzalez AM, Abdullah O, Skjolding AD, Berry M, McAllister JP II and Logan A (2013) Decorin prevents the development of juvenile communicating hydrocephalus. Brain (in press)

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