Professor Una Martin PhD FRCP FBPS FBIHS

Professor Una Martin

Birmingham Medical School
Emeritus Professor

Contact details

Address
Institute of Clinical Sciences
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Professor Una Martin is an Emeritus Professor.

Una was Director of the Institute of Clinical Sciences, Dean of Birmingham Medical School and Professor of Clinical Pharmacology at the University of Birmingham. She was a Consultant in General Medicine and Clinical Pharmacology at University Hospital Birmingham Foundation Trust where she led the Hypertension Service. Professor Martin was also President of the British and Irish Hypertension Society from 2019 - 2021.

Qualifications

  • FBHS Edinburgh 2014
  • FBPS London 2012
  • FRCP London 2007
  • FRCPI Dublin 1998
  • PhD University of Edinburgh 1992 (Drug disposition in Chronic Renal Failure)
  • MRCPI Dublin 1986
  • BSc Pharmacology (First Class Honours)
  • University College Dublin 1985
  • MB BCh BAO University College Dublin 1983 (Honours Medicine & Surgery)

Biography

Una joined the University in 1996 as a part-time Senior Lecturer in the College of Medical and Dental Sciences (MDS) and was promoted to Professor of Clinical Pharmacology in 2015. Key leadership roles within the University have been Programme Director of the National Institute of Health Research (NIHR)/Wellcome Trust Clinical Research Facility (WTCRF) (2011-2015), Athena SWAN lead College of Medical and Dental Sciences (2009-2017), Deputy Pro-Vice Chancellor (DPVC) for Equalities 2015-2020.

Una has had an honorary contract with University Hospital Birmingham Foundation Trust as a consultant in General Medicine and Clinical Pharmacology. She has led and delivered the Hypertension Service at the Trust since 1998, combining clinical care with research into assessment, diagnosis and management of patients with high blood pressure. She was President of the British and Irish Hypertension Society since September 2019 - October 2021.

Una took on the role of Head and Dean of the newly formed Birmingham Medical School in September 2019 and in August 2021 Una became Director of the Institute of Clinical Sciences. Una retired from the University in July 2022.

Teaching

At undergraduate level, Una’s main contribution has been to develop and deliver the 5th year Therapeutics teaching programme and Prescribers’ Licence (previously the Therapeutics OSCE) as module lead for prescribing in the MBChB. The expertise gained was used to develop the National Prescribing Assessment which the College has now adopted. Una was lead for the Hypertension module in the postgraduate MSc in cardiovascular medicine with responsibility for programme design and recruitment of speakers. She is responsible for Clinical Pharmacology training in the West Midlands as Chair of the Specialist Training Committee.

Her national contribution to Clinical Pharmacology has been recognised by a Fellowship from the British Pharmacological Society in 2012. She has completed several terms as External Examiner for Therapeutics in the UK and Ireland.

Postgraduate supervision

Louisa Edwards. Sensory-motor function in hypertension British Heart Foundation PhD awarded 2003; Post Doctoral Research Fellow, 2004-2009 (Co-supervisor)

Tehreem Butt: Patient experiences of Adverse Drug Reactions; MD awarded 2012 (Co-supervisor)

Rebecca Branch: Peripheral neuropathy in hypertension; MPhil awarded 2011 (Principal Supervisor)

Jamie Coleman: Monitoring for adverse drug reactions; MD awarded 2008. (Co-supervisor). 

Abimbola Aiku:  Investigation of mechanisms underlying development of endothelial dysfunction in Asians.  PhD awarded 2020 (Second supervisor with Professor Janice Marshall)

Kyriakos Tsitoglou: Investigation of localised exercise training as a way of reducing cardiovascular risk with ageing in Caucasian and Asian populations. Funded by The Greek Foundation.  (PhD under joint supervision with Professor Janice Marshall)

Research

Current projects

Una’s area of expertise is in hypertension and her contribution to the field has been recognised by a Fellowship of the British Hypertension Society. Her research has had a major impact on how hypertensive patients are diagnosed and treated both in the UK and Internationally.  Highlights include:

She has investigated ethnic differences in blood pressure measured by ambulatory, clinic and home monitoring.

Her clinical experience in ambulatory monitoring (ABPM) informed the design and interpretation of a systematic review published in the BMJ and subsequent cost effective analysis published in the Lancet which led to a major change in NICE guidelines in 2011 (NICE clinical guideline 127).

Her delivery of an ABPM service was used as a template in a subsequent NICE implementation guideline (NICE clinical guideline 127) and her team developed an instruction video on ABPM on behalf of the British Hypertension Society.

She has published several papers relevant to the day to day management of hypertension for example on the relationship between inter-arm blood pressure measurements to ambulatory readings, the problem of adverse drug reactions in antihypertensive treatment in patients aged >80 years, the worrying trend of prescription of inappropriate (and potentially teratogenic) antihypertensive agents to women of child bearing age and the challenges of non-adherence to prescribed medication in patients on long term antihypertensive medication

Other activities

Equalities

Una has been an effective advocate for Athena SWAN at Birmingham. She led the MDS self-assessment team (SAT) which achieved a College, first Silver Award in 2014. As DPVC for Equalities (2015-2019) she established workstreams to include self-assessment teams for the Race Equality Charter (awarded 2020), University Athena SWAN and Stonewall applications. She set up a national network of Academic Equality leads to share good practice and facilitate developments across the sector.

Programme Director of the NIHR/WTCRF

Una was Programme Director of the NIHR/WTCRF, a partnership between the University of Birmingham and University Hospital Birmingham Foundation Trust from 2011-2015. This is a key strategic role for the delivery of Clinical Research in the College of MDS.

Publications

Highlight publications

Sheppard, JP, Albasri, A, Franssen, M, Fletcher, BJ, Pealing, L, Roberts, N, Obeid, A, Pucci, M, McManus, RJ & Martin, U 2018, 'Defining the relationship between arm and leg blood pressure readings: a systematic review and meta-analysis', Journal of Hypertension, vol. 36, no. 1, pp. 600-670. https://doi.org/10.1097/HJH.0000000000001958

Martin, U, Haque, MS, Wood, S, Greenfield, SM, Gill, PS, Mant, J, Mohammed, MA, Heer, G, Johal, A, Kaur, R, Schwartz, C & McManus, RJ 2015, 'Ethnicity and differences between clinic and ambulatory blood pressure measurements', American Journal of Hypertension, vol. 28, no. 6, pp. 729-38. https://doi.org/10.1093/ajh/hpu211

PROOF-BP investigators 2018, 'Prospective external validation of the Predicting Out-of-OFfice Blood Pressure (PROOF-BP) strategy for triaging ambulatory monitoring in the diagnosis and management of hypertension: an observational cohort study', BMJ, vol. 361, k2478. https://doi.org/10.1136/bmj.k2478

Recent publications

Article

Mcdonagh, STJ, Sheppard, JP, Warren, FC, Boddy, K, Farmer, L, Shore, H, Williams, P, Lewis, PS, Baumber, R, Fordham, J, Martin, U, Aboyans, V & Clark, CE 2021, 'Arm Based on LEg blood pressures (ABLE-BP): can systolic leg blood pressure measurements predict systolic brachial blood pressure? Protocol for an individual participant data meta-analysis from the INTERPRESS-IPD Collaboration', BMJ open, vol. 11, no. 3, e040481. https://doi.org/10.1136/bmjopen-2020-040481

Sheppard, JP, Albasri, A, Gupta, P, Patel, P, Khunti, K, Martin, U, McManus, R & Hobbs, R 2021, 'Measuring adherence to antihypertensive medication using an objective test in older adults attending primary care: cross-sectional study', Journal of Human Hypertension. https://doi.org/10.1038/s41371-021-00646-w

Lawson, AJ, Hameed, MA, Brown, R, Cappuccio, FP, George, S, Hinton, T, Kapil, V, Lenart, J, Lobo, MD, Martin, U, Menon, M, Nightingale, A, Rylance, PB, Webb, DJ & Dasgupta, I 2020, 'Nonadherence to antihypertensive medications is related to pill burden in apparent treatment-resistant hypertensive individuals', Journal of Hypertension, vol. 38, no. 6, pp. 1165-1173. https://doi.org/10.1097/HJH.0000000000002398

Hodgkinson, J & Martin, U 2019, 'Schedules for Self-Monitoring Blood Pressure: a Systematic Review', American Journal of Hypertension, vol. 32, no. 4, pp. 350-364. https://doi.org/10.1093/ajh/hpy185

Mukhtar, O, Lip, G & Martin, U 2018, 'A randomized controlled cross-over trial evaluating differential responses to antihypertensive drugs (used as mono- or dual-therapy) on the basis of ethnicity: The - comparIsoN oF optimal hypertension RegiMens; part of the ancestry informative markers in HYpertension programme – AIM-HY INFORM trial', American Heart Journal. https://doi.org/10.1016/j.ahj.2018.05.006

Sheppard, JP, Stevens, S, Stevens, R, Mant, J, Martin, U, Hobbs, R & McManus, RJ 2018, 'Association of guideline and policy changes with incidence of lifestyle advice and treatment for uncomplicated mild hypertension in Primary Care: a longitudinal cohort study in the Clinical Practice Research Datalink', BMJ open, vol. 8, e021827. https://doi.org/10.1136/bmjopen-2018-021827

Sheppard, JP, Stevens, S, Stevens, R, Martin, U, Mant, J, Hobbs, R & McManus, RJ 2018, 'Benefits and harms of antihypertensive treatment for low-risk patients with mild hypertension', JAMA internal medicine, vol. 178, no. 12, pp. 1626-1634. https://doi.org/10.1001/jamainternmed.2018.4684

TASMINH4 investigators 2018, 'Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4): an unmasked randomised controlled trial', The Lancet, vol. 391, no. 10124, pp. 949-959. https://doi.org/10.1016/S0140-6736(18)30309-X

Omer, HMRB, Hodson, J, Pontefract, SK & Martin, U 2018, 'Inpatient falls in older adults: a cohort study of antihypertensive prescribing pre- and post-fall', BMC Geriatrics, vol. 18, 58. https://doi.org/10.1186/s12877-018-0749-8

Monahan, M, Jowett, S, Lovibond, K, Gill, P, Godwin, M, Greenfield, S, Hanley, J, Hobbs, FDR, Mant, J, Martin, U, McKinstry, B, Williams, B, Sheppard, J & McManus, R 2018, 'Predicting Out-Of-Office Blood Pressure (Proof-BP) in the clinic for the diagnosis of hypertension in primary care: an economic evaluation', Hypertension, vol. 71, no. 2, pp. 250–261. https://doi.org/10.1161/HYPERTENSIONAHA.117.10244

Smeuninx, B, McKendry, J, Wilson, D, Martin, U & Breen, L 2017, 'Age-Related anabolic resistance of myofibrillar protein synthesis is exacerbated in obese inactive individuals', Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 9, pp. 3535–3545. https://doi.org/10.1210/jc.2017-00869

Sheppard, JP, Martin, U & McManus, RJ 2017, 'Diagnosis and management of resistant hypertension', Heart, vol. 103, no. 16. https://doi.org/10.1136/heartjnl-2015-308297

Schwartz, C, Christopher, C, Koshiaris, C, Gill, P, Greenfield, S, Haque, MS, Heer, G, Johal, A, Kaur, R, Mant, J, Martin, U, Mohammed, MA, Wood, S & McManus, RJ 2017, 'Interarm Difference in Systolic Blood Pressure in Different Ethnic Groups and Relationship to the "White Coat Effect": A Cross-Sectional Study', American Journal of Hypertension. https://doi.org/10.1093/ajh/hpx073

Comment/debate

Clark, CE, Mcdonagh, STJ, Mcmanus, RJ & Martin, U 2021, 'COVID-19 and hypertension: risks and management. A scientific statement on behalf of the British and Irish Hypertension Society', Journal of Human Hypertension, vol. 35, no. 4, pp. 304-307. https://doi.org/10.1038/s41371-020-00451-x

Other contribution

Jalal, Z, Martin, U, Sajid, M, Ullah Shah, K, Khan, TM & Dar, M 2018, Non-adherence to antihypertensive medication in asian countries: a systematic review and meta-analysis. PROSPERO. <https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=117403>

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