Dr Melissa Grant PhD

Dr Melissa Grant

School of Dentistry
Senior Lecturer in Biological Sciences

Contact details

Address
The School of Dentistry
5 Mill Pool Way
Edgbaston
Birmingham
B5 7EG
United Kingdom

Melissa Grant is a senior lecturer in biological sciences within the School of Dentistry in the Institute of Clinical Sciences. Uniquely situated in both the School of Dentistry and the School of Biosciences she has interdisciplinary collaborations with both scientists and clinicians. She is particularly interested in defining proteomic profiles of inflammatory fluids and understanding the processes and prevention of disease development and progression.

Qualifications

  • PhD Biochemistry, University of Birmingham, 2001.
  • BSc (Hons) Biochemistry, University of Birmingham, 1997.

Biography

Melissa graduated in 1997 with a BSc in Biochemistry and immediately took up a CASE Award (Du Pont) PhD in the laboratories of Dr Dennis Briggs, studying enzymes involved in the germination of wheat grain. These enzymes would ultimately be exploited in the improvement of animal feeds and in bread baking, allowing bread to rise more and yield a ‘fluffier’ loaf.  

She was introduced to the field of proteomic research at the end of her PhD and subsequently went on to set up the proteomic laboratory of Prof Helen Griffiths at Aston University. Leading on from her interests in nutrition Melissa investigated the effects of vitamins C, E and folate on human health and disease, including cancer, Alzheimer’s and heart diseases. She analysed both human plasma samples and cell culture derived samples, generating a number of papers during this post doctoral research.

In 2005 she joined the School of Dentistry's Periodontal Research Group at the University of Birmingham as lead postdoctoral fellow on projects to assess how micronutrients could be used to improve oral health. She was appointed as lecturer in 2011 in biological sciences and has office and laboratory space in both the schools of dentistry and biosciences. She has also continued with her interests in proteomic analysis investigating inflammatory fluids from the gingival crevice and from around inflamed hearing aids. She is co-director of the Periodontal Research Group (PRG). 

Teaching

Melissa has successfully completed the associate program of post graduate certificate in learning and teaching in higher education (PGCert LTHE) and is involved in

Postgraduate supervision

Melissa is interested in supervising doctoral research students in the areas of:

The exploration of periodontal and peri-implant inflammation in humans and other mammals across the life course. 

Understanding disease progression and prevention in the oral cavity or peri-implant.

Research

Melissa’s research centres around interdisciplinary collaborations and clinician-scientist partnerships:

She is involved in a number of projects revealing biomarker discovery, either in programmes of oral health, investigating gingivitis and periodontitis, or at epithelial-implant interfaces in the mouth and surrounding bone anchored hearing aids (BAHAs). Aditionally she is involved in examining the fundamental process of inflammation at the cellular level, particularly of the neutrophil. 

Other activities

Melissa is a member of a number of professional bodies to support her research including: The Biochemical Society; The British Society of Proteome Research, The International Association of Dental Research, The Society of Free Radical Research and the Academy of Osseointegration.  She is an Impact Champion for the School of Dentistry. She has undergone Medici training and Aurora training and is an Athena Swan lead for the School of Dentistry. 

She is an ambassdor for public engagement for the School of Dentistry and former Crucible labs alumna. She continues to collaborate in innovative blue skies research and engage the public and young scientists through public and school presentations, workshops and art-science collaborations, such as the HAB project (which, in collaboration with NASA and Rocket Mavericks, searches for novel extremophiles in the stratosphere that could be exploited for novel functions). She has been a fellow at Birmingham Open MEdia since 2014. She is an academic curator of the Ronald Cohen Collection and leads the Open Wide public engagement project at the School of Dentistry. 

Publications

Milward MR, Ling MR, Grant MM, Chapple IL. Oral Epithelial Cell Culture Model for Studying the Pathogenesis of Chronic Inflammatory Disease.  Methods Mol Biol. 2017;1537:381-401.

Chapple IL, Griffiths HR, Milward MR, Ling MR, Grant MM. Antioxidant Micronutrients and Oxidative Stress Biomarkers.  Methods Mol Biol. 2017;1537:61-77.

 Muzila M, Rumpunen K, Wright H, Roberts H, Grant M, Nybom H, Sehic J, Ekholm A, Widén C.  Alteration of Neutrophil Reactive Oxygen Species Production by Extracts of Devil's Claw (Harpagophytum). Oxid Med Cell Longev. 2016;2016:3841803.

Davis IJ, Jones AW, Creese AJ, Staunton R, Atwal J, Chapple ILC, Harris S & Grant MM. Longitudinal quantification of the GCF proteome during progression from gingivitis to periodontitis in a canine model. J Clin Periodontol. 2016 Jul;43(7):584-94

Roberts H, White P,  Dias I, McKaig S, Thakker N, Grant MM & Chapple ILC. Characterisation of neutrophil function in Papillon Lefévre Syndrome. J Leukoc Biol. 2016 Aug;100(2):433-44

Koro C, Hellvard A, Delaleu N, Binder V, Scavenius C, Bergum B, Główczyk I, Roberts HM, Chapple IL, Grant MM, Rapala-Kozik M, Klaga K, Enghild JJ, Potempa J, Mydel P. Carbamylated LL-37 as a modulator of the immune response. Innate Immun. 2016 Apr;22(3):218-29

SpenglerJ, LugonjaB, Ytterberg AJ, Zubarev RA, Creese A, Pearson MJ, Grant MM, M. Milward M, K. Lundberg K,  Buckley CD, A. Filer A, Raza K, Cooper PR, Chapple IL, D. Scheel-ToellnerD. Activated neutrophils represent a source of extracellular enzymatically active peptidylarginine deiminases, a prerequisite for the production of citrullinated autoantigens in the rheumatoid joint. Annals of the Rheumatic Diseases 2015 Aug 5.

Roberts, HM, Ling MR, Insall R, Kalna, G, Chapple ILC, Grant MM. Impaired neutrophil directional chemotactic accuracy in chronic periodontitis patients. Journal of Clinical Periodontology 2015, 42 :1-11.

Hazeldine J, Harris P, Chapple IL, Grant M, Greenwood H, Livesey A, Sapey E, Lord JM. Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals. Aging Cell. 2014 13:690-8.

Mittal S, Revell M, Barone F, Hardie DL, Matharu GS, Davenport AJ, Martin RA, Grant MM, Mosselmans F, Pynsent P, Sumathi VP, Addison O, Revell PA, Buckley  CD. Lymphoid Aggregates That Resemble Tertiary Lymphoid Organs Define a Specific Pathological Subset in Metal-on-Metal Hip Replacements. PLoS ONE 2013 8: e63470