Dr Rachel Upthegrove MBBS, MRCPsych PhD

Dr Rachel Upthegrove

Institute of Clinical Sciences
Clinical Senior Lecturer

Contact details

Address
Institute of Clinical Science and School of Psychology
The Barberry National Centre for Mental Health
25 Vincent Drive
Birmingham
B15 2FG

Rachel is a Clinical Senior Lecturer in Psychiatry with active research interests in the field of schizophrenia, first episode psychosis, youth mental health, self harm and suicide. Clinically Rachel has worked for over 19 years in psychiatry, 10 of which within the field of Early Intervention in Psychosis.

Qualifications

  • PhD University of Birmingham 2011
  • MPhil University of Birmingham 2001
  • Member of the Royal College of Psychiatrists 1999
  • MBBS University of London 1993

Biography

Rachel qualified with MBBS at the Royal Free Hospital School of Medicine in 1993, and after house jobs and two years of general medicine in London moved to Birmingham to begin a career in Psychiatry. In the closing days of the asylum era, exposure to severe mental illness piqued a longstanding interest in understanding these disorders, comorbidities and predictors of poor and fatal outcomes. As a consultant psychiatrist from 2006, Rachel developed and lead the South Birmingham Early Intervention Service, and latterly served as Head of Profession for the Youth Service.

Teaching

  • BMedSc Psychological Medicine Programme Lead
  • Year 1, 2 and GEC
  • MPharm

Postgraduate supervision

PhD Students

Carl Krynicki 
Markella Grigoriou 
Alexander Tate
Emily Fisher

Research

Rachel’s primary research interests and background encompass the investigation of schizophrenia and psychosis, with particular emphasis on the importance of symptom dimensions and outcomes.

Current projects include:

HuSH: How we Understand Hallucinations. Charitable Trust Funded Study £32,000. C.I. Dr Rachel Upthegrove 2013-2015 Using phenomenological interviews and ethnographic diary methods, the AVH study aims to gain a deeper insight of the experience of hearing voices. The techniques used for data collection have previously been shown to encourage reflexive thinking and foster open discussion. Results obtained will inform further qualitative and neuroimaging work to explore whether themes emerging from this phenomenological approach map onto our current understanding of the biological processes underpinning AVH in schizophrenia and non-psychotic illness.

BioPoP: Biological correlates of dimensional symptoms of psychosis. C.I. Rachel Upthegrove. This study aims to discover whether neuroimaging and cellular biomarkers can be identified for specific symptom dimensions in first episode psychosis. This has important implications for the accurate early identification of patients with poor prognosis and the development of novel, targeted, treatments.

PRONIA: EU FP7 Funded: Personalised Prognostic Tools for Early Psychosis Management. C.I. Nikos Koutsolerious. PRONIA will use routine brain imaging and complementary data to optimise candidate biomarkers for the prediction and staging of psychoses and aim to generate a prognostic system that generalises well across different mental health services. We will also implement new multi-modal risk quantification tools to predict mental health-related disability in young help-seekers. The fusion of these tools with clinical knowledge will produce cybernetic prognostic services that accurately identify help-seekers at the highest risk of psychosis, poor functioning and suicide-related mortality. More information available here

ECLIPSE/CIRCUITS: NIHR PGfAR funded Building Resilience and Recovery through Enhancing Cognition and quality of Life in the early PSychosEs (ECLIPSE) - Study 9: Implementation of Cognitive Remediation into Early Intervention.  C.I. Til Wykes and Eileen Joyce. More information available here

Other activities

  • Consultant Psychiatrist Early Intervention Service
  • Editorial Board British Journal of Psychiatry (Systematic Reviews Editor)
  • British Association for Psychopharmacology: Council Member 2016-
  • Previous Assistant Clinical Director Youth Service, BSMHFT
  • ST4-6 Trainer in Adult Psychiatry
  • Year 5 Welfare Tutor

Publications

Upthegrove R, Ives J, Broome MR, Caldwell K, Wood SJ and Oyebode F. (2016). Auditory verbal hallucinations in first-episode psychosis: a phenomenological investigation. British Journal of Psychiatry Open, 2(1), 88-95.

Marwaha S, Thompson A, Upthegrove R, Broome MR. 15 Years on- Early Intervention for a new generation. British Journal of Psychiatry 209 (3) 186-188

Upthegrove R, Marwaha S and Birchwood M. Depression and schizophrenia: cause, consequence or trans-diagnostic issue? Schizophrenia Bulletin doi: 10.1093/schbul/sbw097

Upthegrove R, Chard C, Jones L, Gordon –Smith K, Forty L, Jones I and Craddock N. (2015) Adverse Childhood Events and Psychosis in Bipolar Affective DisorderBritish Journal of Psychiatry 206 (3) 191-197

Lisiecka D, Suckling J, Thomas RE, Barnes TRE, Chaudhry IB, Dazzan P, Husain N, Jones PB, Joyce EM, Lawrie SM, Upthegrove R and Bill Deakin . The benefit of minocycline on negative symptoms in early-phase psychosis in addition to standard care - extent and mechanism (BeneMin): study protocol for a randomized controlled trial. Trials. (2015) 16:71 DOI 10.1186/s13063-015-0580-

Upthegrove R, Manzanares-Teson N and Barnes NM. Cytokine function in medication-naive first episode psychosis: A systematic review and meta-analysis. 2014 Schizophrenia Research, 155(1), 101-108.

Upthegrove R, Ross K, Brunet K, McCollum R and Jones L. Depression in first episode psychosis: The role of subordination and shame. 2014 Psychiatry Research, 217(3), 177-184.

Upthegrove R, Birchwood M, Ross K, Brunett R, McCollum R and Jones L. The evolution of depression and suicidality in first episode psychosis. Acta Psych Scandinavica 2010, 122:3, 211-218