Dr Hannah Batchelor BSc, PhD

Dr Hannah Batchelor

School of Pharmacy
Senior Lecturer in Pharmaceutics, Formulation and Drug Delivery

Contact details

Address
Pharmacy and Therapeutics Section
Institute of Clinical Sciences
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Hannah Batchelor is a Senior Lecturer in Pharmaceutics, Formulation and Drug Delivery. Her previous experience within pharmaceutical industry and the NHS brings extensive knowledge of drug delivery and the design of clinical trials. Hannah is passionate about involving children and young people in research and undertakes a lot of public engagement activity. 

Her research focuses on the design and manipulation of medicines to create age appropriate drug formulations to maximise clinical efficacy in paediatric patients.  This encompasses pharmaceutical science as well as clinical evaluations of medicines administered to children.

She is an expert in optimisation of drug formulations to maximise their biopharmaceutical performance.

Qualifications

  • Professional Certificate in Learning and Teaching in Higher Education (2003)
  • PhD in Dug Delivery, University of London (2000)
  • BSc in Pharmacology and Chemistry, University of Sheffield (1996)

Biography

Hannah Batchelor graduated from a combined honours degree in Pharmacology and Chemistry at the University of Sheffield in 1996. She went on to work as a formulation scientist at Reckitt and Colman (now Reckitt Benckiser) primarily working on over the counter (OTC) medicines (Gaviscon® and Gaviscon Advance®).

In 2000 she was awarded her PhD in Drug Delivery from the University of London for a research project that explored the use of alginates in coating and protecting the oesophagus from gastric reflux.

She took up a lectureship in Pharmaceutics at Aston University immediately following her PhD where her research efforts focussed on targeted drug delivery systems and gastro-retentive therapies.

In 2008 she joined AstraZeneca as a senior scientist in biopharmaceutics where she worked on several drugs in development and lead the paediatric biopharmaceutics research group.

In 2011 she joined the R&D team at Heart of England NHS Foundation Trust as a Research Portfolio Manager to facilitate NHS lead researchers as well as develop collaborations with regional Universities.

Hannah has been a member of staff at the University of Birmingham since 2012, initially as an NIHR funded research fellow working on age-appropriate paediatric medicines.

Teaching

Hannah Batchelor holds a postgraduate Certificate in Learning and Teaching and has experience in lecturing to undergraduate and postgraduate students. She has also published educational research papers.

She currently teaches on the MSc Pharmaceutical Enterprise; MPharm, MBCHB, Chemical engineering (MEng) programmes at the University of Birmingham.

Outside of the University of Birmingham she teaches on the MSc in Paediatric Medicines Development and Evaluation awarded by the University of Rome Tor Vergata (Global Research in Paediatrics).

She has also taught on a MOOC (Massive open online course) on “Drug Origins” which attracted 5500 participants in 2014.

She was responsible for writing a module within the SCRIPT project on paediatric prescribing (www.safeprescriber.org).

Postgraduate supervision

Hannah Batchelor is interested in supervising research projects in the following areas:

  • The use of scientific principles to design or manipulate medicines for paediatric use.  This includes the formulation of age-appropriate novel products.
  • Generation of understanding of paediatric physiology and biopharmaceutics to ensure clinical efficacy is maximised. This characterisation of the absorption pathways in paediatric patients will aid in the prediction of clinical performance of medicines.
  • Development of in silico tools to predict drug performance in paediatric populations. This can include de-risking potential clinical studies.

If you are interesting in studying any of these subject areas please contact Hannah on the contact details above, or for any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk  or call +44 (0)121 414 5005.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings

Research

The main research themes are:

  • Evaluation of the barriers to administration of paediatric medicines and the assessment of acceptability of paediatric medicines and dosing devices
  • Scientific understanding of the impact of manipulation of existing medicines for use in children
    • Including understanding and implications of manipulations of medicines with food and/or drink
    • On their acceptability to the traget population
  • Generation of understanding of paediatric biopharmaceutics to best design medicines for children
    • Including in vivo relevant dissolution testing
    • In vivo relevant drug release/diffusion from formulations and manipulated medicines
  • Demonstrate the value of in silico modelling to predict the performance of medicines in children to minimise testing in patients where possible
    • Including a review of PK and bridging studies in paediatric populations

She is currently co-supervising a PhD project; Konstantinos Stamatopoulos on, “In-vivo fluid mechanical models of drug delivery to the colon and in-vitro testing methods”. With Prof Mark Simmons, School of Chemical Engineering, University of Birmingham.   This was featured on the BBC inside Science programme.

She is also involved in an Innovate UK funded project, “Accelerating paediatric formulation development through smart design and predictive science“ that involves collaborators from AstraZeneca, Pfizer, Bristol Myers Squibb and GSK.  

Other activities

Hannah Batchelor is a member the Clinical Research Network: Children, funded by the National Institute for Health Research, which is dedicated to supporting research into many different aspects of health care. 

Hannah gave a TEDx talk in April 2015 

Hannah is also the paediatric biopharmaceutics workstream leader within the European Paediatric Formulation Initiative (www.eupfi.org). 

Outreach activities to talk to children and young people about medicines and clinical research are an important aspect of Hannah’s work. She has visited schools, hospitals and community events.

See her personal website for further details 

Hannah has been invited to present at several National and International meetings on paediatric medicines development 

An online webinar is available from the  Global Research in Paediatrics (GRiP) series of "Meet the Expert in Paediatric Formulations".  This session "In-vitro biopharmaceutic methods in the development of oral dosage forms for children" 3rd October 2013 

Publications

  1. K Stamatopoulos, H K Batchelor, F Alberini, M JH Simmons (2016) Use of PLIF to assess the mixing performance of small volume USP 2 apparatus in shear thinning media. Chemical Engineering Science. 149:1-9
  2. Gilchrist, F., Ahmed, A., Batchelor, H., Marriott, J. & Lenney, W. (2016) A review of prednisolone prescribing for children with acute asthma in the UK. Journal of Asthma.
  3. Wan, M., Al Hashimi, A. & Batchelor, H. (2016) Pharmacy and formulation support for paediatric clinical trials in England. International Journal of Pharmaceutics available online: 30-MAR-2016 DOI information: 10.1016/j.ijpharm.2016.03.059
  4. R H Venables, H K Batchelor, H Stirling, J F Marriott. 2016. Barriers to administering non-oral formulations in a paediatric population: A semi-structured interview study. International Journal of Pharmaceutics, vol. 497(1-2), 12-17.
  5. H K Batchelor, R Appleton, D B Hawcutt. (2015) Comparing paediatric intravenous phenytoin doses using physiologically based pharmacokinetic (PBPK) modelling software. Seizure. 2015 Dec;33:8-12. doi: 10.1016/j.seizure.2015.10.006.
  6. K Stamatopoulos, H K Batchelor, F Alberini, J Ramsay, M JH Simmons (2015) Understanding the impact of media viscosity on dissolution of a highly water soluble drug within a USP 2 mini vessel dissolution apparatus using an optical planar induced fluorescence (PLIF) method.  International Journal of Pharmaceutics, Volume 495, Issue 1, 10 November 2015, Pages 362-373, ISSN 0378-5173, http://dx.doi.org/10.1016/j.ijpharm.2015.09.002.
  7. H K Batchelor, R H Venables, S Ranmal,  C Tuleu. 2015. Oral formulations for paediatrics: palatability studies. Hospital Pharmacy Europe (http://www.hospitalpharmacyeurope.com/drug-delivery/oral-formulations-paediatrics-palatability-studies)
  8. R Venables, H Stirling, H K Batchelor and John Marriott (2015) Problems with oral formulations prescribed to children: a focus group study of healthcare professionals. International Journal of Clinical Pharmacy. Published online July 2015 DOI 10.1007/s11096-015-0152-x
  9. H K Batchelor. (2015) Influence of food on paediatric gastrointestinal drug absorption following oral administration: a review. Children (2015) 2:244-271 doi:10.3390/children2020244
  10. H K Batchelor, S Salunke and C Tuleu. (2015) Formulating better medicines for children—reflections. International Journal of Pharmaceutics. Published online 7th May 2015. DOI: 10.1016/j.ijpharm.2015.05.017 (IF=3.46)
  11. F Liu, S Ranmal, HK Batchelor, M Orlu-Gul, TB Ernest, IW Thomas, T Flanagan, R Kendall, C Tuleu. (2015) Formulation factors affecting acceptability of oral medicines in children. International Journal of Pharmaceutics. Published online 13th May 2015 . DOI: 10.1016/j.ijpharm.2015.05.013  (IF=3.46)
  12. H K Batchelor and J F Marriott. (2015). Formulations for children: problems and solutions. British Journal of Clinical Pharmacology. 79(3):405-418 DOI: 10.1111/bcp.12268 (IF = 3.58)
  13. H K Batchelor and J F Marriott. (2015). Paediatric pharmacokinetics: key considerations. British Journal of Clinical Pharmacology. 79(3):395-404 DOI: 10.1111/bcp.12267 (IF = 3.58)
  14. R Venables, H K  Batchelor, J Hodson, H Stirling, J Marriott. (2015) Determination of formulation factors that affect oral medicines acceptability in a domiciliary paediatric population, International Journal of Pharmaceutics, Volume 480, Issues 1–2, 1 March 2015, Pages 55-62 (IF = 3.46)
  15. H K  Batchelor, R H Venables, J F Marriott, T Mills. (2015) The application of tribology in assessing texture perception of oral liquid medicines, International Journal of Pharmaceutics, Volume 479, Issue 2, 20 February 2015, Pages 277-281  (IF = 3.46)
  16. F Liu, S Ranmal, HK Batchelor, M Orlu-Gul, TB Ernest, IW Thomas, T Flanagan, C Tuleu. (2014) Patient-Centred Pharmaceutical Design to Improve Acceptability of Medicines: Similarities and Differences in Paediatric and Geriatric Populations. Drugs. Published online: 2 October 2014 DOI 10.1007/s40265-014-0297-2 (IF=4.13)
  17. H K  Batchelor, N Fotaki and S Klein. (2014) Paediatric Biopharmaceutics. Advanced Drug Delivery Reviews. 73: 102-126 http://dx.doi.org/10.1016/j.addr.2013.10.006  (IF = 12.89)
  18. H K  Batchelor. (2014) Paediatric Biopharmaceutics Classification System: Current status and future decisions. International Journal of Pharmaceutics. 469(2)251-253. http://dx.doi.org/10.1016/j.ijpharm.2014.02.046 (IF = 3.46)
  19. HK Batchelor, JF Marriott, RH Venables, J Hodson, HF Stirling (2014) Tablets or liquids for children: who decides and why? Arch Dis Child 2014;99:Suppl 1 A162-A163 Published Online First: 7 April 2014 doi:10.1136/archdischild-2014-306237.374
  20. HK Batchelor, JF Marriott, RH Venables, HF Stirling, C Callens, K Hughes, C Miller. Tablet preferences in children and young people. Arch Dis Child 2014;99:Suppl 1 A168 Published Online First: 7 April 2014 doi:10.1136/archdischild-2014-306237.384
  21. R Venables, H K  Batchelor, H Stirling and J F Marriott. (2013) Making the decision – liquids or tablets for children? International Journal of Pharmacy Practice 21 (Suppl. 2):122-123 DOI: 10.1111/ijpp.12064 
  22. H K  Batchelor, (2007) A constructivist method for teaching concentration calculations to pharmacy students. Pharmacy Education 7(1):69-76

  23. H K  Batchelor, (2004), The importance of a mathematics diagnostic test for incoming pharmacy undergraduates.  Pharmacy Education. 4(2):69-74

  24. H K  Batchelor, (2004), Diagnostic test for pharmacy students as a successful learning and teaching tool. MSOR Connections Vol 4 No 4.