Dr Martyn Chidgey PhD

Dr Martyn Chidgey

Institute of Clinical Sciences
Senior Lecturer

Contact details

Address
Institute of Clinical Sciences
College of Medical and Dental Sciences
University of Birmingham
Cancer Sciences Building
Vincent Drive
Birmingham, B15 2TT

Martyn Chidgey is a Senior Lecturer in the Institute of Clinical Sciences.  His main research interest is in the biology of desmosomes, intercellular junctions of epithelial tissues and cardiac muscle.  He has published numerous research papers, reviews, book chapters and encyclopaedia entries on the topic.  Martyn is heavily involved in teaching and lectures to medical, dental, science and pharmacy undergraduate students.

Qualifications

  • PhD Biochemistry 1983 
  • BSc Biochemistry 1979

Biography

Martyn Chidgey qualified with a BSc and PhD in Biochemistry from Cardiff University.  He subsequently worked as a Research Fellow at a number of UK institutions including St. Mary’s Hospital Medical School (now part of Imperial College), Leicester University and the University of Manchester.  Martyn developed his research interest in desmosomes whilst in the last of these posts.  He joined the University of Birmingham as a Lecturer in 1999, and has continued his work on desmosomes and their role in human disease. 

Teaching

Year Lead for Biological Sciences teaching (BDS Year 1)

 Module Co-Ordinator for:

  • Introduction to biomedical sciences (BDS Year 1)
  • Fundamentals of life science (BSc Biomedical science Year 1)
  • Cancer and stratified medicine (BSc Biomedical science Year 2 (joint with Professor Malcolm Taylor)
  • Elective preparation (MBChB Year 4)
  • Elective and report (MBChB Year 5)

Lecturer and Small Group Teacher for MBChB, BDS, BSc Biomedical science and Pharmacy students. 

Student wellbeing:

Year 4 (Welfare) Tutor for MBChB course.

Personal Mentor for MBChB and BSc Biomedical Sciences courses.  

Postgraduate supervision

Martyn is interested in supervising doctoral research students in the following areas:

  • The cell, molecular and structural biology of desmosomes and their proteins

If you are interesting in studying any of these subject areas please contact Martyn on the contact details above, or for any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk or call +44 (0)121 414 5005.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

The main focus of Martyn’s laboratory is to investigate the role of desmosomes in the biology of epithelial tissues and cardiac muscle, both in normal development and disease.  Desmosomes are intercellular junctions that are essential for the maintenance of tissue integrity, and are abundant in tissues such as the skin and heart, that are subjected to mechanical stress.  Loss of desmosomal adhesion can result in devastating skin blistering diseases such as pemphigus, and unexpected heart failure in arrhythmogenic right ventricular cardiomyopathy (ARVC).  Martyn is interested in the role of desmosomes in cell differentiation, wound healing and cancer.  He is working on the cell and structural biology of desmosomal proteins such as desmocollin, desmoglein and desmoplakin, using techniques such as transfection and immunocytochemistry, and nuclear magnetic resonance spectroscopy and X-ray crystallography, to learn about their structure and interactions at the cellular and molecular level.  

Publications

Fogl F, Mohammed F, Al-Jassar C, Jeeves M, Knowles TJ, Rodriguez-Zamora P, White SA, Odintsova E, Overduin M and Chidgey M (2016) Mechanism of intermediate filament recognition by plakin repeat domains revealed by envoplakin targeting of vimentinNature Communications  7, 10827

Jeeves M, Fogl C, Al-Jassar C, Chidgey M and Overduin M (2016) Sequence-specific 1H, 13C and 15N backbone resonance assignments of the plakin repeat domain of human envoplakin. Biomol. NMR Assign.  10, 167-170.

Al-Jassar C, Bikker H, Overduin M and Chidgey M (2013). Mechanistic basis of desmosome-targeted diseases J. Mol. Biol.  425, 4006-4022.

Al-Jassar C, Bernado P, Chidgey M and Overduin M (2013). Hinged plakin domains provide specialized degrees of articulation in envoplakin, periplakin and desmoplakin. PLoS ONE 8, e69767.

Al-Jassar C, Knowles T, Jeeves M, Kami K, Behr E, Bikker H, Overduin M and Chidgey M. (2011). The non-linear structure of the desmoplakin plakin domain and the effects of cardiomyopathy-linked mutations. J. Mol. Biol. 411, 1049-1061.

Kami K, Chidgey M, Dafforn T and Overduin M (2009). The desmoglein-specific cytoplasmic region is intrinsically disordered in solution and interacts with multiple desmosomal protein partners. J. Mol. Biol. 386, 531-543.