Trudy Knight embarked on a career in pharmaceutical sciences, with the aim of gaining substantial experience in all aspects of Professional Pharmacy. She worked in several NHS Hospitals, in various specialities, including Clinical Ward Pharmacy, Pharmaceutical Manufacture of sterile and non-sterile products, Quality Control (Analytical Chemistry and Microbiology), Drug Information and Teaching pre-registration Pharmacists.
Throughout this time, she developed, not only her original interest in pharmacology and therapeutics, but also in the adverse effects of drugs, safe prescribing, and skills in production of personalised formulations to avoid toxicity, in particular for dermatological conditions and paediatric patients. She is particularly interested in manifestation and mechanisms of idiosyncratic drug reactions. Her PhD study was on the molecular basis of immune-mediated hepatotoxicity induced by halothane, in the Department of Pharmacology and Toxicology, at St. Mary’s Hospital Medical School, London.
Trudy further expanded her experience in pharmaceutical toxicological work by employments in Academia, and in Pharmaceutical Industries (Roche Pharmaceuticals plc, and Faulding Pharmaceuticals plc.) in areas of Pharmacologjcal and Toxicological Research, Regulatory Affairs, Evidence Based Pharmacotherapy, Systematic Reviews and Health Technology Assessments, and Teaching Pharmacology. At the University of Birmingham, she has worked on the Birmingham Graduate Entry (MBChB) Course (GEC).
Trudy also has concern for human safety following inhalational exposures to chemicals in the environment and occupations, and is presently based in the Institute of Occupational and Environmental Medicine at the University of Birmingham. She is currently working (p/t) as Project Manager of the large multidisciplinary academic nano- research project, FABLE (From Airborne Exposures to Biological Effects: the impact of nanoparticles on human health) funded (£2.2million) by NERC/MRC. The research investigates the nature of metal nanoparticles found in ambient and indoor environments, synthesis and characterisation of metal nanoparticles, investigation of their ability to cross cellular membranes and their intracellular behaviour, and their toxicity in various cell types in vitro, and in in vivo models. The work is done in several laboratories across Birmingham University campus, at the University of Aberdeen and at Public Health England in Oxford. Trudy is also involved with environmental and health government organisations, with the aim of finally transferring outcomes of the project to inform policy.