Professor Karla Hemming PhD

Professor Karla Hemming

Institute of Applied Health Research
Professor of Biostatistics

Contact details

Address
Public Health, Epidemiology and Biostatistics
Institute of Applied Health Research
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham, B15 2TT

Karla is a Professor of Biostatistics at the Institute of Applied Health Research, University of Birmingham, UK. Karla’s research interests include how to design cluster and stepped-wedge trials so as to maximise their statistical efficiency and minimise their risk of bias; how to model time and treatment effect heterogeneity in longitudinal cluster trials; and the ethical issues surrounding these pragmatic trial designs, such as ethical oversight and consent. Karla has recently led the CONSORT extension for the stepped-wedge cluster randomised trial.

Teaching

Postgraduate supervision

Karla Hemming's research interests include perinatal epidemiology, meta-analysis, missing data and cluster trials. She has conducted and published research in a number of areas, including:

Prescribing errors in electronic prescribing
Large-scale organisational intervention to improve patient safety
Bayesian sensitivity models for missing covariates in the analysis of survival data
Meta-regression with partial information

Publications

Recent publications

Article

Hemming, K, Melo, P, Luo, R, Taljaard, M & Coomarasamy, A 2023, 'A re‐analysis of 150 women's health trials to investigate how the Bayesian approach may offer a solution to the misinterpretation of statistical findings', BJOG: An International Journal of Obstetrics & Gynaecology. https://doi.org/10.1111/1471-0528.17570

Al-Khudairy, L, Akram, Y, Watson, SI, Kudrna, L, Hofman, J, Nightingale, M, Alidu, L, Rudge, A, Rawdin, C, Ghosh, I, Mason, F, Perera, C, Wright, J, Boachie, J, Hemming, K, Vlaev, I, Russell, S & Lilford, RJ 2023, 'Evaluation of an organisational-level monetary incentive to promote the health and wellbeing of workers in small and medium-sized enterprises: a mixed-methods cluster randomised controlled trial', PLOS Global Public Health, vol. 3, no. 7, e0001381. https://doi.org/10.1371/journal.pgph.0001381

Dickinson-Craig, E, Badarch, J, Bartington, S, Hemming, K, Thayakaran, R, Day, R, Pope, F, Chuluunbaatar, B, Boldbaatar, D, Ochir, C, Warburton, D, Thomas, GN & Manaseki-Holland, S 2023, 'Impact assessment of a raw coal ban on maternal and child health outcomes in Ulaanbaatar: a protocol for an interrupted time series study', BMJ open, vol. 13, no. 4, e061723. https://doi.org/10.1136/bmjopen-2022-061723

Hemming, K & Taljaard, M 2023, 'Key considerations for designing, conducting and analysing a cluster randomized trial', International Journal of Epidemiology, pp. 1-11. https://doi.org/10.1093/ije/dyad064

Martin, J, Middleton, L & Hemming, K 2023, 'Minimisation for the design of parallel cluster-randomised trials: An evaluation of balance in cluster-level covariates and numbers of clusters allocated to each arm', Clinical Trials, vol. 20, no. 2, pp. 111–120. https://doi.org/10.1177/17407745221149104

Watson, S, Girling, A & Hemming, K 2023, 'Optimal Study Designs for Cluster Randomised Trials: An Overview of Methods and Results', Statistical methods in medical research. , pp. 1-23. https://doi.org/10.1177/09622802231202379

Watson, SI, Akinyemi, JO & Hemming, K 2023, 'Permutation-based multiple testing corrections for p-values and confidence intervals for cluster randomised trials', Statistics in Medicine. https://doi.org/10.1002/sim.9831

Prevention Workplace Collaboration West Midlands 2023, 'Protocol for a cluster randomised waitlist-controlled trial of a goal-based behaviour change intervention for employees in workplaces enrolled in health and wellbeing initiatives', PLoS ONE, vol. 18, no. 9, e0282848. https://doi.org/10.1371/journal.pone.0282848

Asamane, EA, Quinn, L, Watson, SI, Lilford, RJ, Hemming, K, Sidibe, C, Rego, RT, Bensassi, S, Diarra, Y, Diop, S, Gautam, OP, Islam, MS, Jackson, L, Jolly, K, Kayentao, K, Koita, O, Manjang, B, Tebbs, S, Gale, N, Griffiths, PL, Cairncross, S, Toure, O & Manaseki-Holland, S 2023, 'Protocol for a parallel group, two-arm, superiority cluster randomised trial to evaluate a community-level complementary-food safety and hygiene and nutrition intervention in Mali: the MaaCiwara study (version 1.3; 10 November 2022)', Trials, vol. 24, no. 1, 68. https://doi.org/10.1186/s13063-022-06984-5

Gallos, I, Devall, A, Martin, J, Middleton, L, Beeson, L, Galadanci, H, Alwy al-Beity, F, Qureshi, Z, Hofmeyr, GJ, Moran, N, Fawcus, S, Sheikh, L, Gwako, G, Osoti, A, Aswat, A, Mammoliti, K, Sindhu, KN, Podesek, M, Horne, I, Timms, R, Yunas, I, Okore, J, Singata-Madliki, M, Arends, E, Wakili, AA, Mwampashi, A, Nausheen, S, Muhammad, S, Latthe, P, Evans, C, Akter, S, Forbes, G, Lissauer, D, Meher, S, Weeks, A, Shennan, A, Ammerdorffer, A, Williams, E, Roberts, T, Widmer, M, Oladapo, OT, Lorencatto, F, Bohren, MA, Miller, S, Althabe, F, Gülmezoglu, M, Smith, JM, Hemming, K & Coomarasamy, A 2023, 'Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage', New England Journal of Medicine, vol. 389, no. 1, pp. 11-21. https://doi.org/10.1056/NEJMoa2303966

Hemming, K, Taljaard, M, Gkini, E & Bishop, J 2023, 'Sample size determination for external pilot cluster randomised trials with binary feasibility outcomes: a tutorial', Pilot and Feasibility Studies, vol. 9, no. 1, 163. https://doi.org/10.1186/s40814-023-01384-1

Daniels, J, Dixon, EF, Gill, A, Bishop, J, D’Amico, M, Ahmed, K, Dodds, J, Tryposkiadis, K, Wilks, M, Millar, M, Husain, S, Gray, J, Whiley, A, Moore, PV, Munetsi, RL, Hemming, K, Roberts, T, Plumb, J, Deeks, J, Khan, KS & Thangaratinam, S 2022, 'A rapid intrapartum test for group B Streptococcus to reduce antibiotic usage in mothers with risk factors: the GBS2 cluster RCT', Health Technology Assessment, vol. 26, no. 12, pp. vii-76. https://doi.org/10.3310/BICF1187

Hemming, K, Javid, I & Taljaard, M 2022, 'A review of high impact journals found that misinterpretation of non-statistically significant results from randomized trials was common', Journal of Clinical Epidemiology, vol. 145, pp. 112-120. https://doi.org/10.1016/j.jclinepi.2022.01.014

Bick, D, Bishop, J, Coleman, T, Dean, S, Edwards, E, Frawley, H, Gkini, E, Hay-Smith, J, Hemming, K, Jones, E, Oborn, E, Pearson, M, Salmon, V, Webb, S & MacArthur, C 2022, 'Antenatal preventative pelvic floor muscle exercise intervention led by midwives to reduce postnatal urinary incontinence (APPEAL): protocol for a feasibility and pilot cluster randomised controlled trial', Pilot and Feasibility Studies, vol. 8, no. 1, 231. https://doi.org/10.1186/s40814-022-01185-y

Review article

Quinn, L, Veenith, T, Bion, J, Hemming, K, Whitehouse, T & Lilford, R 2022, 'Bayesian analysis of a systematic review of early versus late tracheostomy in ICU patients', British Journal of Anaesthesia, vol. 129, no. 5, pp. 693-702. https://doi.org/10.1016/j.bja.2022.08.012

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