Ye Htun Oo is a Medical Research Council Clinician Scientist at Centre for Liver Research, University of Birmingham and Honorary Consultant Hepatologist at UHB NHS Foundation Trust.
Ye is a clinical academic and his major clinical interest include liver transplantation, viral and autoimmune hepatitis. He conducts dedicated viral and autoimmune hepatitis clinics, involved in DAA clinical trials and hepatitis C vaccination trials.
He is an Honorary Consultant Hepatologist in Liver Transplant and Hepato-biliary Department at University Hospital Birmingham NHS Foundation Trust.
Ye’s major basic research interests are in hepatic tolerance, pathogenesis of liver inflammation and repair in autoimmune liver diseases, chronicity of HCV & HBV infection and operational tolerance.
He aims to translate understanding of scientific background for future cell and cytokine therapy for patients with autoimmune, viral hepatitis and in liver transplantation. His current focus is on understading the balance of effector immune cells and regulatory T/B cells in human liver inflammation.
He aim to restore immune homeostasis with GMP grade autologous regulatory T cells as part of his translational cell therapy programme.
Ye research team bridge both basic science and translational work. Currently his group consists of two post-doctoral scientists, one PhD student and intercated medical students.
Research theme (Basic Science)
A) Effector and Treg balance in liver inflammation and fibrosis
B) Innate and adaptive immune cells crosstalk with Treg in hepatic inflammation and fibrosis
c) Tumor Immunology
D) Viral Immunology
Research theme (Translational)
GMP grade Human Regulatory T cells theapy
Research theme (Clinical)
Dedicated AIH clinic
Post transplant HCV clinic
Full list of publications
Regulatory T cell directed therapies in liver diseases
YH Oo, S Sakaguchi
Journal of Hepatology 2013 Nov (in press)
CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver.
Oo YH, Banz V, Kavanagh D, Liaskou E, Withers DR, Humphreys E, Reynolds GM, Lee-Turner L, Kalia N, Hubscher SG, Klenerman P, Eksteen B, Adams DH.
J Hepatol. 2012 Nov;57(5):1044-51.
Regulatory T cells and autoimmune hepatitis: defective cells or a hostile environment?
Oo YH, Adams DH.
J Hepatol. 2012 Jul;57(1):6-8.
Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man;
Barnes E, Folgori A, Capone S, Swadling L, Aston S, Kurioka A, Meyer J, Huddart R, Smith K, Townsend R, Brown A, Antrobus R, Ammendola V, Naddeo M, O'Hara G, Willberg C, Harrison A, Grazioli F, Esposito ML, Siani L, Traboni C, Oo Y, Adams D, Hill A,Colloca S, Nicosia A, Cortese R, Klenerman P.
Sci Transl Med. 2012 Jan 4;4(115):115ra1.
Entecavir treatment for chronic hepatitis B: adaptation is not needed for the majority of naïve patients with a partial virological response. Zoutendijk R, Reijnders JG, Brown A, Zoulim F, Mutimer D, Deterding K, Petersen J, Hofmann WP, Buti M, Santantonio T, van Bömmel F, Pradat P, Oo Y, Luetgehetmann M, Berg T, Hansen BE, Wedemeyer H, Janssen HL; VIRGIL Surveillance Study Group.
Hepatology. 2011 Aug;54(2):443-51
Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver; Journal of Immunology; 2010 Mar 15;184(6):2886-98
YH Oo, C Weston, P F Lalor, S Curbishley, DR Withers, GM Reynolds, S Shetty, J Harki, JC Shaw, B Eksteen, SG Hubscher, LS Walker, DH Adams
Analysis of CD161 expression on human CD8+ T cells defines a functional subset with tissue-homing properties;
Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3006-11)
Billerbeck E, Kang YH, Walker L, Lockstone H, Grafmueller S, Fleming V, Flint J, Willberg CB, Bengsch B, Seigel B, Ramamurthy N,
Zitzmann N, Barnes EJ, Thevanayagam J, Bhagwanani A, Leslie A, YH Oo, Kollnberger S, Bowness P, Drognitz O, Adams DH, Blum HE, Thimme R, Klenerman P.
Tacrolimus and Cyclosporin doses and blood levels in Hepatitis C and Alcoholic liver disease patients after liver transplantation
YH Oo, T Dudley, P Nightingale, G Haydon, D Mutimer
Liver Transplantation 2008, Jan 14(1) 81-87