Alastair Denniston is Hon Senior Lecturer, College of Medical and Dental Sciences and Consultant Ophthalmologist (Uveitis and Medical Retina) at the University Hospitals Birmingham NHS Foundation Trust.
Alastair’s specialist interest within ophthalmology is ocular immunity. He was awarded an MRC Clinical Research Training Fellowship in 2006, and completed his PhD in Dendritic Cell Regulation in the Ocular Microenvironment in 2009. He regularly publishes research papers in scientific journals as well as reviews and book chapters, but is best known for writing the Oxford Handbook of Ophthalmology with Professor Philip Murray (Professor of Ophthalmology and Head of the Academic Unit of Ophthalmology, University of Birmingham).
Alastair is keen to promote awareness of ophthalmic research and has been actively involved with the MRC Max Perutz Science Writing Prize (runner-up in 2009) and the British Science Festival.
Alastair’s motivation, whether in research or in the clinic, is to improve our care of patients with potentially blinding ocular disease.
Denniston A.K., Tomlins P., Williams G.P., Kottoor S, Khan I.J., Oswal K., Salmon M., Wallace G.R., Rauz S., Murray P.I., Curnow S.J. Aqueous humor suppression of dendritic cell function helps maintain immune regulation in the eye during human uveitis Invest Ophthalmol Vis Sci 2012;53(2):888-96.
Hamada S, Khan I, Denniston A.K., Rauz S. Childhood Blepharokeratoconjunctivitis: Characterising a Severe Phenotype in White Adolescents. Br J Ophthalmol 2012 (In Press)
Williams G.P., Denniston A.K.O., Oswal K.S., Tomlins P.J., Barry R.J., Rauz S.,Curnow S.J. The dominant human conjunctival epithelial CD8ab+ T cell population is maintained with age but the number of CD4+ T cells increases. Age (Dordr). 2011 (In Press)
Sreekantham S., Denniston A.K.(Joint first author), Murray P.I. Survey of expert practice and perceptions of the supporting clinical evidence for the management of uveitis-related cataract and cystoid macular oedema Ocular Immunology and Inflammation 2011; 19(5):353-7
Trivedi D., Denniston A.K., Murray P.I. Safety profile of anterior chamber paracentesis performed at the slit lamp. Clinical and Experimental Ophthalmology 2011 (In Press)
Denniston A.K., Kottoor S.H., Khan I., Oswal K., Williams G.P., Abbott J., Wallace G.R., Salmon M., Rauz S., Murray P.I., and Curnow S.J. Endogenous cortisol and TGF-beta in human aqueous humour contribute to ocular immune privilege by regulating dendritic cell function. Journal of Immunology 2011;186(1):305-11.
Mandal N., Harborne P., Salmon N., Holder R., Denniston A.K., Murray P.I. Comparison of two ophthalmoscopes for direct ophthalmoscopy. Clinical and Experimental Ophthalmology 2010:39(1);30-36
Curnow S.J., Fariclough M.E., Schmutz C., Kissane S., Denniston A.K., Nash K., Buckley C.D., Lord J. and Salmon M. Distinct types of fibrocyte differentiate from mononuclear cells in the presence and absence of serum. PLOS One 2010; 5(3):e9730
Aralikatti A.M.V., Mitra A., Denniston A.K., Haque M.S., Ewer A.K., Butler L. Is ethnicity a risk factor for severe retinopathy of prematurity? Arch Dis Child 2010; 95(3):F174-6
Nessim M., Denniston A.K., Nolan W., Holder R., Shah P. ReGAE 8: Is There A Relationship Between Social Deprivation And Acute Primary Angle Closure? Br J Ophthalmol 2010;94(10):1304-6.
Sood V,. Rahman R, Denniston A.K. Phacoemulsification and foldable intraocular lens implant combined with 23 gauge transconjunctival sutureless vitrectomy J Cataract Refract Surg 2009; 35(8): 1380-4.
Simon D., Denniston A.K., Tomlins P.J., Wallace G.R., Rauz S., Salmon M., Murray P.I., Curnow S.J. Soluble gp130, an antagonist of IL-6 trans-signalling, is elevated in uveitis aqueous humour Invest Ophthalmol Vis Sci 2008; 49: 3988-91