Dr Adriana Flores-Langarica PhD

 

Postdoctoral fellow

School of Immunity and Infection

AdrianaFlores-Langarica-Cropped-110x146

Contact details

School of Immunity and Infection
College of Medical and Dental Sciences
Medical School Building
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

About

Adriana Flores-Langarica is a post doctoral research fellow working in Professor Adam Cunningham’s group in the School of Immunity and Infection.

Her main research interest is the induction of the immune response in vivo. She is currently investigating the importance of different dendritic cell subsets and their impact to the T and B cell responses during Salmonella infection.

Qualifications

  • PhD in Immunology. National School of Biological Sciences. Mexico. 2005.
  • MSc in Experimental Pathology. Centre for Advanced Research, CINVESTAV-IPN, Mexico. 2003
  • BSc Biology. National University of Mexico UNAM. 2001

Biography

Dr. Flores received her PhD. in Immunology by the The National School of Biological Sciences in Mexico in 2005 from where she moved to The Rockefeller University to work in antigen targeting to dendritic cells and adjuvant strategies. She carried on working in DCs biology at the University of Oxford for two years. And in 2008 she incorporated to the University of Birmingham to work at Dr. Cunningham Lab studying immune responses in vivo infection models.

Publications

Marshall JL, Flores-Langarica A, Kingsley RA, Hitchcock JR, Ross EA, López-Macías C, Lakey J, Martin LB, Toellner KM, Maclennan CA, Maclennan IC, Henderson IR, Dougan G, Cunningham AF. (2012) The capsular polysaccharide Vi from Salmonella typhi is a B1b antigen. J Immunol. 15;189(12):5527-32.

Flores-Langarica A, Marshall JL, Hitchcock J, Cook C, Jobanputra J, Bobat S, Ross EA, Coughlan RE, Henderson IR, Uematsu S, Akira S, Cunningham AF. (2012) Systemic flagellin immunization stimulates mucosal CD103+ DCs and drives FoxP3+ Treg and IgA responses in the mesenteric lymph node. J Immunol. 15;189(12):5745-54.

Ross EA, Coughlan RE, Flores-Langarica A, Lax S, Nicholson J, Desanti GE, Marshall JL, Bobat S, Hitchcock J, White A, Jenkinson WE, Khan M, Henderson IR, Lavery GG, Buckley CD, Anderson G, Cunningham AF. (2012) Thymic function is maintained during Salmonella-induced atrophy and recovery. J Immunol. 1;189(9):4266-74.

Withers DR, Gaspal FM, Mackley EC, Marriott CL, Ross EA, Desanti GE, Roberts NA, White AJ, Flores-Langarica A, McConnell FM, Anderson G, Lane PJ. (2012) Cutting Edge: Lymphoid tissue inducer cells maintain memory CD4 T cells within secondary lymphoid tissue. J Immunol. 1;189(5):2094-8.

Ross EA, Coughlan RE, Flores-Langarica A, Bobat S, Marshall JL, Hussain K, Charlesworth J, Abhyankar N, Hitchcock J, Gil C, López-Macías C, Henderson IR, Khan M, Watson SP, Maclennan IC, Buckley CD, Cunningham AF. (2011) CD31 is required on CD4+ T cells to promote T cell survival during Salmonella infection. J Immunol. 15;187(4):1553-65.

Flores-Langarica A, Marshall JL, Bobat S, Mohr E, ‎Hitchcock J, Ross E, Coughlan R, Khan M, Van Rooijen N, Henderson IR, MacLennan ICM, Cunningham AF. (2011) T Zone Localized Monocyte-Derived Dendritic Cells Promote Th1 Priming to Salmonella. Eur J Immunol. 41(9):2654-65. PMID: 21630252.

Bobat S*, Flores-Langarica A*, Hitchcock J, Marshall JL, Kingsley RA, Goodall M, Gil-Cruz C, Serre K, Leyton DL, Letran SE, Gaspal F, Chester R, Chamberlain JL, Dougan G, López-Macías C, Henderson IR, Alexander J, Maclennan IC, Cunningham AF. (2011) Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella Typhimurium infection. Eur J Immunol. 41(6):1606-18. *Equally contributing authors.

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