Trish Lalor is a non-Clinical lecturer in The Centre for Liver research. She is a PhD supervisor for clinical fellows and basic science students in the Centre for Liver Research, supervises undergraduate research projects, and acts as a personal mentor for MBChB students
Trish has published over 30 research papers in scientific journals as well as reviews and book chapters in the fields of leukocyte recruitment, endothelial biology and liver disease. Her research has been supported by research grants from The Medical Research Council, The Wellcome Trust, BBSRC, NIH and The European Union and by commercial collaborations with Unilever.
She is currently a member of the Editorial Board of the ‘World Journal of Gastroenterology’ and ‘World Journal of Hepatology’ and also acts as a language editor for several titles in this journal series. She has served on the editorial board of the journal ‘Transplantation’. Trish was a member of the school faculty for The European Association for the Study of the Liver (EASL) Basic Hepatology School, and served as a scientific representative on the committee responsible for The British Association for the Study of the Liver (BASL)
Trish is currently supervising doctoral research students in the areas of liver inflammation and links with metabolic regulation, liver endothelial biology and leukocyte and stem cell recruitment.
For any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk or call +44 (0)121 414 5005.
For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.
RESEARCH THEMES
Liver inflammation, liver endothelial biology, stem cell recruitment, hepatic disease pathogenesis
RESEARCH ACTIVITY
Dr Lalors research focuses on using a cell biological approach to understand the molecular mechanisms of hepatic disease. In particular she has a long-standing interest in the phenotype and function of the unique endothelial cells (HSEC) which line the hepatic sinusoid. Her research involves using complex multicellular models, cell co-cultures and human tissue samples to understand the regulation of HSEC phenotype and function and how these cells contribute to the immune environment within the hepatic sinusoid. A particular area of interest is the regulation of leukocyte and stem cell recruitment and retention within the liver, and these studies use novel flow-based models to recreate the shear-stress in the sinusoidal environment. Trish also has ongoing studies investigating the detailed phenotype of HSEC at a genetic level and how these cells may contribute to glucose and lipid homeostasis and alcohol-induced liver injury.
Shetty S, Weston CJ, Oo YH, Westerlund N, Stamataki Z, Youster J, Hubscher SG, Salmi M, Jalkanen S, Lalor PF, Adams DH. (2011) Common Lymphatic Endothelial and Vascular Endothelial Receptor-1 Mediates the Transmigration of Regulatory T Cells across Human Hepatic Sinusoidal Endothelium. J Immunol (In press)
E.Liaskou, C.Weston, P.F Lalor, N. Pullen, S.Jalkanen, D.H Adams (2011) Regulation of MAdCAM-1 expression in human liver tissue by amine oxidase activity. Hepatology 53(2):661-72.
Aspinall AI, Curbishley SM, Lalor PF, Weston CJ; Miroslava Blahova, Liaskou E, Adams RM, Holt AP, Adams DH. (2010) CX(3)CR1 and vascular adhesion protein-1-dependent recruitment of CD16(+) monocytes across human liver sinusoidal endothelium Hepatology. Jun;51(6):2030-9
Lalor PF, Curbishley SM and Adams DH (2010) Identifying homing interactions in T cell traffic in human disease. Methods Mol Biol. 616:231-52.
Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH (2010) Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver J Immunol. 184(6):2886-98
Kavanagh DP, Durant LE, Crosby HA, Lalor PF, Frampton J, Adams DH, Kalia N (2010) haematopoetic stem cell recruitment to injured murine liver sinusoids depends on (alpha)4(beta)1 integrin/VCAM-1 interactions. GUT 59 (1) 79-87
Crosby HA, Lalor PF, Ross E, Newsome PN, Adams DH (2009) Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4. J Hepatol.;51(4):734-49
Holt AP, Haughton EL, Lalor PF, Filer A, Buckley CD, Adams DH (2009) Liver myofibroblasts regulate infiltration and positioning of lymphocytes in human liver. Gastroenterology 136(2):705-14