Jonathan studied pre-clinical medicine at the University of Oxford and clinical medicine at the University of Cambridge. Following qualification in 2005 he worked as a doctor in East Anglia before moving to Birmingham in 2007 to work with Professor Christopher Buckley as an Academic Clinical Fellow in Rheumatology.
Jonathan has a longstanding keen interest in inflammatory pathology and development of novel therapeutics for the treatment of such illnesses. For three years from 2009 he worked at Merck Research Laboratories, California, on the role of interleukin-23 in spondyloarthropathy. He returned to clinical rheumatology as a Clinical Lecturer in Birmingham in 2012.
Jonathan Sherlock works on the role of inflammatory cytokines in spondyloarthropathy, particularly the role of interleukin(IL)-23. This work has demonstrated that these conditions are driven by IL-23 which acts upon IL-23 responsive cells resident in the canonical sites of pathology such as the entheseal insertions of tendons and ligaments to bone.
IL-23 induces spondyloarthropathy by acting on ROR-γt(+) CD3(+)CD4(-)CD8(-) entheseal resident T cells.
Sherlock JP, Joyce-Shaikh B, Turner SP, Chao CC, Sathe M, Grein J, Gorman DM, Bowman EP, McClanahan TK, Yearley JH, Eberl G, Buckley CD, Kastelein RA, Pierce RH, Laface DM, Cua DJ. Nature Medicine 2012 Jul 1;18(7):1069-76
Autoimmunity's collateral damage: Gut microbiota strikes 'back'. Cua DJ, Sherlock JP.
Nature Medicine 2011 Sep 7;17(9):1055-6
Evidence-based management of ANCA vasculitis. Carruthers D, Sherlock J.
Best Pract Res Clin Rheumatol. 2009 Jun;23(3):367-78
A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis.
Hou TZ, Bystrom J, Sherlock JP, Qureshi O, Parnell SM, Anderson G, Gilroy DW, Buckley CD.
FEBS Lett. 2010 Sep 24;584(18):3955-61
Myasthenia gravis: diagnosis delayed or missed Sherlock J, McGourty J, Brown J
Geriatric Medicine 2007 3:49-53
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain.
Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W, Kwan S, Churakova T, Zurawski S, Wiekowski M, Lira SA, Gorman D, Kastelein RA, Sedgwick JD. Nature. 2003 Feb 13;421(6924):744-8
Red cell indices as predictors of iron depletion in blood donors. Alexander HD, Sherlock JP, Bharucha C.
Clin Lab Haematol. 2000 Oct;22(5):253-8