Samantha has several years’ experience as a non-clinical cell biologist working primarily on human hematopoietic and endothelial cells. Throughout her career, she has investigated how the normal and pathological functions of endothelial cells are regulated by their biochemical, cellular and physical microenvironments.
She is currently working within Prof Roy Bicknell’s research team which investigates (i) the location, targeting and possible function/s of tumour endothelial markers in specific cancers at the cellular/ molecular level. Dr Tull is specifically investigating the role of ECSCR (a highly expressed endothelial marker) in angiogenesis and tumour progression. The ultimate aim of this research is to develop new or improved cancer treatments.
Her previous research focused on how alterations in endothelial behaviour mediate the underlying inflammatory processes which occur during development of chronic cardiovascular and renal diseases.
She has utilised these cells predominantly in static and flow based adhesion assays to determine the molecular events governing adhesive interactions and affecting the development of chronic inflammatory diseases of the vasculature. After entering the field of renal immunobiology, she supervised and/or mentored two PhD studentships. This small research group investigated the role of neutrophil derived proteases in vasculitis.
This work was expanded to study cross-talk between glomerular cells and its role in vasculitis. As a part of this research, they embarked on a deeper exploration of the role of microenvironments in vasculitis, studying (i) endothelial-stromal interactions (ii) neutrophil and macrophage recruitment (iii) the lipid environment (lipid composition, antioxidants, signaling) and (iv) and the counter-play between these factors and neutrophil-derived proteases. Two scientific papers were published from the renal study in PLoS One (a 1st authorship) and Nephrology Dialysis Transplantation (a last authorship).
Before entering the renal field, her previous research focused on cardiovascular disease. This earlier period was also productive as she set up, or was directly involved in, projects where findings were published in the following journals: Atherosclerosis; Circulation Research; Blood; Journal of Vascular Surgery; British Journal of Surgery; Annals of Clinical Biochemistry; International Journal of Experimental Pathology and Kidney International (impact factor 7.916, 6.968); Journal of Nutrition (impact factor 4.196, 4.686- joint first authorship); PLoS biology (impact factor 12.690 5 year 13.447- first authorship).
Kuravi SJ, Bevins A (jointed first), Satchell SC, Harper L, Williams JM, Rainger GE, Savage CO. Tull SP (2012). Neutrophil serine proteases mediate inflammatory cell recruitment by glomerular endothelium and progression towards dysfunction.- Nephrology Dialysis and Transplantation Dec;27(12):4331-8.
Tull SP, Bevins A, Kuravi SJ, Satchell SC, Al-Ani B, Young SP, Harper L, Williams JM, Rainger GE, Savage CO (2012). PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells. PLoS One;7(8):e43916. doi: 10.1371/journal.pone.0043916. Epub 2012 Aug 29.
Yates CM, Tull SP (jointed first), Madden J, Calder PC, Grimble RF, Nash GB, Rainger GE (2011). The omega-3-polyunsaturated fatty acid, Docosahexaenoic acid (DHA), inhibits the adhesion of flowing neutrophils to cytokine stimulated endothelial cells J Nutr. Jul;141(7):1331-4.
Tull SP, Yates CM, Maskrey BH, O'Donnell VB, Madden J, Robert F. Grimble RF, Calder PC, Nash GB, Rainger G.E. Omega-3 Fatty Acids and Inflammation: Novel Interactions Reveal a New Step in Neutrophil Recruitment (2009). PLoS Biol 7(8): August issue
Luu NT, Madden J, Calder PC, Grimble RF, Shearman CP, Chan T, Tull SP, Dastur N, Rainger GE, Nash GB (2007). Comparison of the pro-inflammatory potential of monocytes from healthy adults and those with peripheral arterial disease using an in vitro culture model. Atherosclerosis. Aug;193(2):259-68
Tull SP, Anderson SI, Hughan SC, Watson SP, Nash GB, Rainger GE (2006). Cellular Pathology of Atherosclerosis: Smooth Muscle Cells Promote Adhesion of Platelets to Cocultured Endothelial Cells. Circulation Research Jan 6;98(1):98-104
Hayes PD, Tull S, Hayes NJ, Goodall AH, Thompson MM, Bell PRF, London NJM, Naylor, AR (2005). Thromboembolic events after carotid endarterectomy are associated with the HPA-3 platelet receptor polymorphism. British Journal of Surgery April Vol 92(4) 507-8
Williams JC, Fotherby MD, Forster LA, Tull SP, Ferns GA. Mononuclear cell adhesion to collagen ex vivo is related to pulse pressure in elderly subjects (2000). Atherosclerosis Aug;151(2):463-9