Mark Webber studied for a BSc (Hons) in Microbiology from the University of Birmingham between 1994 and 1997. He went on to complete a master’s degree in Medical Microbiology and Infectious diseases (1998) and then study for a PhD in the School of Immunity and Infection between 1998 and 2001 with Professor Laura Piddock. Subsequently Mark has continued to work in Birmingham investigating aspects of multiple antibiotic resistance, bacterial stress responses and biofilm formation, predominantly in Grgam negative pathogens.
Mark was awarded a BBSRC David Phillips fellowship to study novel mechanisms of resistance to the common antimicrobial, triclosan in 2007.
Mark is active within the antimicrobial resistance research community and was appointed as an Editor for the Journal of Antimicrobial Chemotherapy in December 2006, was appointed as an Editor for the Journal of Medical Microbiology in November 2009 and appointed to the editorial board of PLoS ONE in December 2010. Mark was co-organiser of both the ‘Antimicrobial Resistance Mechanisms Workshops’ in Nov 2009 and Nov 2010, which attracted ~110 academic attendees from the UK.
Mark was awarded the 2010 WH Pierce prize for ‘Outstanding contribution to microbiology’ by the Society for Applied Microbiology. He acts as an expert assessor of grant applications for the Wellcome trust, British Society for Antimicrobial Chemotherapy, Agencie National de la Recherche and Irish Health Research Board. Mark also is an expert member of the CAAMIC (centre for application of advanced materials in infection control) panel.
Mark is interested in supervising doctoral research students in the following areas:
The role of stress as a signal and how supercoiling can alter global gene expression.
How does adaptation to high density life (biofilm) alter metabolite and drug transport
If you are interesting in studying any of these subject areas please contact Mark on the contact details above, or for any general doctoral research enquiries, please email: firstname.lastname@example.org or call +44 (0)121 414 5005.
For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.
Microbial drug resistance, Bacterial stress responses, Regulation of gene expression, Mechanisms of biofilm formation
Biocide-antibiotic cross resistance
The main focus of Marks current work (supported by his fellowship and a project grant from BBSRC) is investigation of how exposure of bacteria to biocides can select for cross resistance to antibiotics. The role of generic stress responses relevant to both biocide and antibiotic resistance are being investigated using a combination of contemporary sequencing, transcriptomic and proteomic approaches to identify key loci involved in increased tolerance to biocides and antibiotics. Most of this work focuses on the food borne pathogen Salmonella.
Efflux pumps and biofilm formation
Recently Mark has been involved in work demonstrating that multidrug efflux systems have roles beyond solute export in Gram negative bacteria, this includes a requirement for some efflux systems to be intact to form a normal biofilm. Mark supervises a PhD project investigating the mechanisms by which multidrug efflux systems contribute to biofilm formation, again in Salmonella.
Transferable antibiotic resistance
Mark also has an interest in mobile genetic elements which mediate transfer of antibiotic resistance genes, he co-supervises a PhD student with Professor Laura Piddock who has determined the sequence of a plasmid carrying an extended spectrum beta lactamase and designed a PCR based molecular test to follow its epidemiology in isolates around the world. Mark also has an active collaboration with a Nigerian research group where levels of antibiotic resistance are very high and has characterised the nature of resistance genes and plasmids present in Nigeria which may act as a reservoir for spread of resistance around the world.
Cottell JL, Webber MA, Coldham NG, Taylor D, Cerdeño-Tárraga Ana, Hauser H, Thomson N, Woodward MJ, Piddock LJ. (2011), Complete Sequence and Molecular Epidemiology of an IncK Epidemic Plasmid Encoding bla CTX-M-14 Widely Disseminated in Humans and Animals. Emerging Infectious Diseases. In press.
Porsby CH, Webber MA, Nielsen KF, Piddock LJ, Gram L. (2011), Resistance and Tolerance to Tropodithietic Acid, an Antimicrobial in Aquaculture, is Hard to Select. Antimicrob Agents Chemother. Jan 24. [Epub ahead of print]
Ogbolu DO, Daini OA, Ogunledun A, Alli AO, Webber MA. (2011), High levels of multidrug resistance in clinical isolates of Gram-negative pathogens from Nigeria. Int J Antimicrob Agents. 37(1):62-6.
Copitch JL, Whitehead RN, Webber MA. (2010), Prevalence of decreased susceptibility to triclosan in Salmonella enterica isolates from animals and humans and association with multiple drug resistance. Int J Antimicrob Agents. 36(3):247-51.
Webber MA, Coldham NG. (2010), Measuring active efflux in gram-negative bacteria. Methods Mol Biol. 642:173-80.
Chaudhuri RR, Sebaihia M, Hobman JL, Webber MA, Leyton DL, Goldberg MD, Cunningham AF, Scott-Tucker A, Ferguson PR, Thomas CM, Frankel G, Tang CM, Dudley EG, Roberts IS, Rasko DA, Pallen MJ, Parkhill J, Nataro JP, Thomson NR, Henderson IR. (2010), Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042. PLoS One. 20;5(1):e8801.
Gunell M, Webber MA, Kotilainen P, Lilly AJ, Caddick JM, Jalava J, Huovinen P, Siitonen A, Hakanen AJ, Piddock LJ. (2009), Mechanisms of resistance in non-typhoidal Salmonella enterica exhibiting a non-classical quinolone resistance phenotype. Antimicrob Agents Chemother. 53(9):3832-3836.
Webber MA, Bailey AM, Blair JM, Morgan E, Stevens MP, Hinton JC, Ivens A, Wain J, Piddock LJ. (2009), The global consequence of disruption of the AcrAB-TolC efflux pump in Salmonella enterica includes reduced expression of SPI-1 and other attributes required to infect the host. J Bacteriol. 191(13):4276-85.