Dr Chris Weston BSc PhD

 

Post-Doctoral Research Fellow

School of Immunity and Infection

ChrisWeston-Cropped-110x146

Contact details

Telephone +44 (0)121 415 8784

Fax +44 (0)121 415 8701

Email c.j.weston@bham.ac.uk

NIHR Biomedical Research Unit and Centre for Liver Research
5th Floor Institute for Biomedical Research
The Medical School
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

About

Chris Weston is a post-doctoral research fellow based in the Centre for Liver Research who has received grant funding from the MRC and the Wellcome Trust.

His research focus is the regulation of immune mediated injury and fibrosis in the human liver, with a view to establish the role that amine oxidases such as vascular adhesion protein-1 (VAP-1) and the lysyl oxidase family (LOX, LOXL1-4) play in this process. He is also interested in the development of therapeutic agents to target inflammatory liver disease and works closely with clinical colleagues to facilitate the transition from bench to bedside.

Qualifications

  • PhD Biochemistry, Birmingham 2001
  • BSc Biochemistry with Biotechnology, Birmingham 1998

Biography

Dr Weston graduated in Biochemistry with Biotechnology from the University of Birmingham in 1998. He then completed a PhD in Biochemistry at Birmingham in the laboratory of Prof. Baz Jackson working on the transhydrogenase of Entamoeba histolytica which controls the balance of reducing equivalents, as NAD(H) and NADP(H), in the cell.

He then took up a post-doctoral position shared between the Schools of Biosciences and Chemistry at Birmingham working on small catalytic peptides and DNA-binding proteins with Dr. Oliver Smart and Prof. Rudolf Allemann.

Chris joined the NIHR Biomedical Research Unit Centre for Liver Research in 2004, working with Prof. David Adams on the mechanisms of inflammatory cell recruitment in chronic liver disease and is currently involved in projects ranging from the establishment of fibrosis, tumour immunology, leukocyte recruitment to hepatic manifestations of the metabolic syndrome. He is currently employed on a Wellcome Trust Programme grant investigating the role of Vascular Adhesion Protein-1 in hepatic inflammation and disease progression.

Teaching

Postgraduate supervision

Chris is interested in supervising doctoral research students in the following areas:

  • The role of amine oxidases in liver disease and primary liver cancer
  • Lymphocyte recruitment to the human liver

If you are interesting in studying any of these subject areas please contact Chris on the contact details above, or for any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk or call +44 (0)121 414 5005

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

RESEARCH THEMES
Chronic and acute inflammation, liver immunology, clinical trials, amine oxidases, fibrosis, tumour immunology

RESEARCH ACTIVITY
The establishment of chronic liver disease results from a persistence of hepatic insult leading to inflammation and scarring (fibrosis). Lymphocyte recruitment to the injured liver is mediated by specialised endothelial cells that line the liver blood channels (sinusoids). Dr Weston’s research focus is the study of the complex interactions between liver infiltrating immune cells and the hepatic endothelium using flow-based adhesion assays, confocal microscopy and transfection technologies. As part of this research Chris is exploring the role of amine oxidases, such as vascular adhesion protein-1 (VAP-1), in the establishment of liver disease and determining their contribution to the development of hepatic inflammation and fibrosis in vivo and in vitro. The aims of these research activities are the identification of novel biomarkers of hepatic injury and the development of therapeutic agents for the treatment of chronic liver disease.

Patent: “Use of VAP-1 inhibitors for treating fibrotic conditions (WO/2011/029996)”

Other activities

  • Membership of the British Association for the Study of the Liver
  • STEM ambassador to promote Science and Technology for children and young people

Publications

Weston CJ, Shepherd EL and Adams DH
Cellular localization and trafficking of Vascular Adhesion Protein-1 as revealed by an N-terminal GFP fusion protein
J Neural Transm., 2013 Jun; 120(6):951-61

Shetty S*, Bruns T*, Weston CJ, Stamataki Z, Oo YH, Long HM, Reynolds GM, Pratt G, Moss P, Jalkanen S, Hubscher SG, Lalor PF and Adams DH
Recruitment mechanisms of primary and malignant B cells to the human liver
Hepatology, 2012; 56(4):1521-31

Bhogal RH, Weston CJ, Curbishley SM, Adams DH and Afford SC
Activation of CD40 with platelet derived CD154 promotes reactive oxygen species dependent death of human hepatocytes during hypoxia and reoxygenation
PLoS One, 2012; 7(1):e30867

Bhogal RH, Weston CJ, Curbishley SM, Adams DH and Afford SC
Autophagy: A Cyto-Protective Mechanism which Prevents Primary Human Hepatocyte Apoptosis During Oxidative Stress
Autophagy, 2012; 8(4):545-58

Weston CJ and Adams DH
Hepatic consequences of Vascular Adhesion Protein-1 Expression
J. Neural Transm. 2011; 118(7), 1055-1064

Bhogal RH, Hodson J, Bartlett DC, Weston CJ, Curbishley SM, Haughton E, Williams KT, Reynolds GM, Newsome PN, Adams DH and Afford SC
Isolation of primary human hepatocytes from normal and diseased liver tissue: a one hundred liver experience
PLoS One. 2011; 6(3):e18222

Bhogal RH, Weston CJ, Curbishley SM, Bhatt AN, Adams DH and Afford SC
Variable responses of small and large human hepatocytes to hypoxia and hypoxia/reoxygenation (H-R)
FEBS Lett. 2011; 585(6), 935-941

Shetty S, Weston CJ, Oo YH, Westerlund NM, Stamataki Z, Youster J, Hubscher SG, Salmi M, Jalkanen S, Lalor PF and Adams DH
Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium
J. Immunol. 2011; 186(7), 4147-4155

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