Dr Ye Htun Oo MBBS, MRCP, PhD

Dr Ye Htun Oo

Institute of Immunology and Immunotherapy
Medical Research Council Clinician Scientist
Consultant Hepatologist

Contact details

Telephone
+44 (0)121 414 8700
Fax
+44 (0)121 414 8701
Email
y.h.oo@bham.ac.uk
Address
Centre for Liver Research & NIHR Birmingham Liver Biomedical Research Unit
5th Floor, IBR, University of Birmingham
Liver and Hepatobiliary Unit, UHB NHS Foundation Trust
Wolfson Drive, Edgbaston, Birmingham, B15 2TH

Ye Htun Oo is a Medical Research Council Clinician Scientist at Centre for Liver Research, University of Birmingham and Honorary Consultant Hepatologist at UHB NHS Foundation Trust.

Ye is a clinical academic and his major clinical interest include liver transplantation, viral and autoimmune hepatitis. He conducts dedicated viral and autoimmune hepatitis clinics, involved in DAA clinical trials and hepatitis C vaccination trials.

He is an Honorary Consultant Hepatologist in Liver Transplant and Hepato-biliary Department at University Hospital Birmingham NHS Foundation Trust.

Ye’s major basic research interests are in hepatic tolerance, pathogenesis of liver inflammation and repair in autoimmune liver diseases, chronicity of HCV & HBV infection and operational tolerance.

He aims to translate understanding of scientific background for future cell and cytokine therapy for patients with autoimmune, viral hepatitis and in liver transplantation. His current focus is on understading the balance of effector immune cells and regulatory T/B cells in human liver inflammation.

He aim to restore immune homeostasis with GMP grade autologous regulatory T cells as part of his translational cell therapy programme.

Qualifications

  • MRC Clinician Scientist & Consultant Transplant Hepatologist (2012-
  • CCST General Internal Medicine/Gastroenterology 2011
  • PhD  (Regulatory T cells and Th17/Tc17 subsets) 2010
  • Member of Royal College of Physicians 2001
  • MBBS 1995

Biography

Ye qualify in Medicine in 1995 from Rangoon, Burma. He joined West Midlands Gastroenterology/Hepatology training programme in 2002 where he completed his clinical training in Gastroenterology/ General Internal Medicine and Transplant Hepatology. He studied PhD on Hepatic Immunology particularly focusing on hepatic tolerance and human Regulatory T cells and intrahepatic lymphocyte subsets balance in liver inflammation and repair under supervision of Pro VC and Dean, Professor David Adams. Following his PhD, he invested a year to develop GMP grade regulatory T cells with a vision to apply as new therapy in immune mediated liver diseases. He is also involved in HBV and HCV therapeutic vaccination and VIRGIL project on Hepatitis B.

He received a Clinician Scientist fellowship award from Medical Research Council in Jan 2012 to investigate both basic and preclinical study on Regulatory T cells homing with a subsequent plan to develop future translational Treg therapy. He joined his colleagues in Liver Medicine clinical team as a Consultant Transplant Hepatologist in Jan 2012.

Teaching

Teaching Programmes

Postgraduate supervision

Ye is interested in supervising PhD on research fellows and students in the following areas:

  • Hepatic tolerance in relation to effector cells and regulatory T cells balance
  • Hepatic innate cells crosstalk with Treg in hepatic inflammation and fibrosis
  • Gut-Liver link with micro biome.
  • Role of IL-17 in hepatic repair.

If you are interesting in studying any of these subject areas please contact Ye on y.h.oo@bham.ac.uk or the contact details above.

Research

Research theme (Basic Science)

  • Hepatic tolerance in relation to effector cells and regulatory T cells balance.
  • Innate cell crosstalk with Treg in hepatic inflammation and fibrosis
  • Gut-Liver link with microbiome.
  • Role of IL-17 in hepatic repair.

Research theme (Translational)

  • GMP grade autologous human Regulatory T cells therapy in liver diseases.
  • Cytokine therapy

Research team

Ye’s research team bridge both basic science and translational therapy exploring new immunological markers, predictors (CyTOF), OMIC profiles for patients’ stratification and developing new cell and cytokine therapies for his patients’ care. He leads an active research team with cross-collaboration nationally, across Europe, Asia and US.

Clinical Research Activities

  • Dedicated AIH clinic
  • Post transplant HCV clinic

Research grants

  1. Medical Research Council Intermediate Fellowship
  2. QEH Charity
  3. UK- Autoimmune Hepatitis (UK-AIH) deep immunophenotyping grant (NIHR Rare Disease Translational Research Collaboration).
  4. BDRF grant

Other activities

  • Honorary Consultant Hepatologist
  • British Association for Study of the Liver Disease member
  • European Association for Study of the Liver Disease member
  • American Association for Study of the Liver Disease member
  • Member of British Viral Hepatitis Group
  • Sutton Runners

Publications

Full list of publications

Accepted article

BACTERIA EXPOSED BILIARY EPITHELIUM AND LIVER B CELLS ACTIVATE
INTRAHEPATIC MAIT CELLS IN AN MR1-DEPENDENT MANNER
Journal of Hepatology
Hannah C Jeffery*1, Bonnie van Wilgenburg*2, Ayako Kurioka2, Krishan Parekh1, Kathryn Stirling1, Sheree Roberts1, Emma E Dutton3, Stuart Hunter1, Daniel Geh1, Manjit K Braitch1, Jeremy Rajanayagam1, Tariq Iqbal4, Thomas Pinkney4, Rachel Brown4, David R Withers3, David H Adams1,4, Paul Klenerman*2 & Ye Htun Oo*1,4


AUTOIMMUNE HEPATITIS: PROGRESS FROM GLOBAL IMMUNOSUPPRESSION TO PERSONALISED REGULATORY T CELL THERAPY

Canadian Journal of Gastroenterology & Hepatology
Nwe Ni Than, Hannah C Jeffery, Ye Htun Oo