Dr Shishir Shetty MRCP PhD

Image of Shishir Shetty

Institute of Immunology and Immunotherapy
Wellcome Trust Intermediate Clinical Fellow
Honorary Consultant Hepatologist

Contact details

Address
Centre for Liver Research/Institute of Immunology and Immunotherapy/ MRC Centre for Immune Regulation/ Institute of Biomedical Research
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Shishir Shetty is a clinician scientist in the Centre for Liver Research/ National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit and honorary consultant hepatologist at the Queen Elizabeth Liver Transplant Unit, Birmingham. He has received grant funding from the Wellcome Trust, the Core Charity, The Bardhan Research and Education Trust and the Rosetrees charity

Shishir’s research focus is the regulation of leucocyte recruitment to the liver and the role of novel adhesion molecules including scavenger receptors. He is also studying how scavenger receptors influence the tissue microenvironment in fibrosis and cancer. The overall aim is to identify new targets of therapy for inflammatory liver disease and primary liver cancer. His clinical interests include the management of hepatocellular cancer and co-existing liver disease.

Qualifications

  • CCT, 2011
  • PhD Immunology, 2011
  • Membership of the Royal College of Physicians, 2002
  • MbChB, 1999

Biography

Dr Shetty graduated in Medicine from the University of Leicester in 1999. He undertook his general medical training in Liverpool and then specialised in gastroenterology and hepatology, initially in London followed by the West Midlands. During his specialist training he obtained a research fellowship from the CORE charity and Bardhan Research and Education Trust to work on lymphocyte trafficking supervised by Professor David Adams and Dr Patricia Lalor in the University of Birmingham. 

He gained his PhD in 2011 and also received his Certificate of Completion of Training in gastroenterology and general medicine. In the same year he was awarded a Wellcome Trust Intermediate Fellowship that commenced in April 2012. In recognition of the work produced during his PhD he was awarded the CORE research prize in 2012 and the Dame Sheila Sherlock research medal in 2013.

The focus of his Wellcome Trust fellowship is to study the role of CLEVER-1, a C-type Lectin, in chronic inflammatory liver disease. Shishir is also an honorary consultant hepatologist at the Queen Elizabeth Hospital Birmingham and works in the liver unit with a special interest in hepatocellular carcinoma.

Teaching

Postgraduate supervision

Dr Shetty is interested in supervising doctoral research students in the following areas:

  • Lymphocyte adhesion and migration via hepatic endothelium.
  • Lymphocyte subset recruitment to the inflamed liver.
  • The role of C-type lectins in chronic liver disease and primary liver cancer.

If you are interested in studying any of these subject areas please contact Dr Shetty on the contact details above, or for any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk or call +44 (0)121 414 5005.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

Inflammatory liver diseases follow a common pathway with chronic tissue injury leading to the recruitment and activation of immune cells followed by excess extracellular matrix deposition by activated liver resident pericytes (hepatic stellate cells) driving the development of fibrosis. Dr Shetty’s research theme is related to the recruitment and activation of immune cells during chronic liver disease. He has focused on the receptor CLEVER-1/stabilin-1 which is expressed on sinusoidal endothelium and subsets of macrophages. His recent work has demonstrated that this receptor plays a critical role in tissue homeostasis within the liver and protects against fibrosis. 

Another research focus is lymphocyte recruitment which occurs within the unique environment of the hepatic sinusoids lined by hepatic endothelium. He studies lymphocyte subset interactions with hepatic endothelium using flow adhesion assays and confocal microscopy. The aim is to identify receptors that modulate lymphocyte recruitment, which could be therapeutic targets for liver disease. 

During his PhD, he demonstrated that CLEVER-1 mediated the recruitment of regulatory T cells and B cells via hepatic sinusoidal endothelium. He also described a novel pathway of lymphocyte migration through hepatic endothelium via a transcellular route.

Other activities

  • Member of the Royal College of Physicians
  • Member of British Gastroenterology Society
  • Member of British Association for the Study of the Liver

Publications

Patten DA, Wilson GK, Bailey D, Shaw RK, Jalkanen S, Salmi M, Rot A, Weston CJ, Adams DH and Shetty S (2016) Human liver sinusoidal endothelial cells promote intracellular crawling of lymphocytes during recruitment- a new step in migration. Hepatology [Epub ahead of print]

Than NN, Ghazanfar A, Hodson J, Tehami N, Coldham C, Mergental H, Manas D, Shah T, Newsome PN, Reeves H and Shetty S (2016) Comparing clinical presentations, treatments and outcomes of hepatocellular carcinoma due to Hepatitis C and Non Alcoholic Fatty Liver Disease. QJM [Epub ahead of print]

Hoare M, Ito Y, Kang T, Weekes M, Matheson MJ, Patten DA, Shetty S,  Parry AJ, Menon S, Salama R, Antrobus R, Tomimatsu K, Howat W, Lehner PJ, Zender L and Narita M (2016) NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol 18(9):979-92

Rantakari P, Patten DA, Valtonen J, Karikoski M, Gerke H, Dawes H, Laurila J,  Ohlmeier S, Elima K, Hubscher SG, Weston CJ, Jalkanen S, Adams DH, Salmi M and Shetty S (2016) Stabilin-1expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury. Proc Natl Acad Sci U S A 113(33):9298-303

Shetty S, Weston CJ, Adams DH and Lalor PF (2014) A flow adhesion assay to study leucocyte recruitment to human hepatic sinusoidal endothelium under conditions of shear stress. J Vis Exp (85)

Shetty S, Adams DH and Hubscher SG *2012) Post-transplant liver biopsy and the immune response: lessons for the clinician. Expert Rev Clin Immunol 8(7):645-61

Shetty S, Bruns T, Weston CJ, Stamataki Z, Oo YH, Long HM, Reynolds GM, Pratt G, Moss P, Jalkanen S, Hubscher SG, Lalor PF and Adams DH (2012) Recruitment mechanisms of primary and malignant B cells to the human liver. Hepatology 56(4):1521-31

Shetty S, Weston C, Oo YH, Westerlund N, Stamataki Z, Youster J, Hubscher SG, Salmi M, Jalkanen S, Lalor PF and Adams DH (2011) Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium. J Immunol 186(7):4147-55