Dr Shetty graduated in Medicine from the University of Leicester in 1999. He undertook his general medical training in Liverpool and then specialised in gastroenterology and hepatology, initially in London followed by the West Midlands. During his specialist training he obtained a research fellowship from the CORE charity and Bardhan Research and Education Trust to work on lymphocyte trafficking supervised by Professor David Adams and Dr Patricia Lalor in the University of Birmingham.
He gained his PhD in 2011 and also received his Certificate of Completion of Training in gastroenterology and general medicine. In the same year he was awarded a Wellcome Trust Intermediate Fellowship that commenced in April 2012. In recognition of the work produced during his PhD he was awarded the CORE research prize in 2012.
The focus of his Wellcome Trust fellowship is to study the role of CLEVER-1, a C-type Lectin, in chronic inflammatory liver disease. Shishir is also an honorary consultant hepatologist at the Queen Elizabeth Hospital Birmingham and works in the liver unit with a special interest in hepatocellular carcinoma.