Dr Alice M Turner MBChB (Hons), MRCP, PGCE (MedEd), PhD

Dr Alice Turner

Institute of Inflammation and Ageing
Senior Clinical Lecturer
Honorary Consultant Respiratory Physician

Contact details

Institute of Inflammation and Ageing
Centre for Translational Inflammation Research
Mindelsohn Way
B15 2WB

Alice Turner (nee Wood) is a Senior Clinical Lecturer and Consultant in Respiratory Medicine.

Alice’s research interests are predominantly in chronic obstructive pulmonary disease and alpha 1 antitrypsin deficiency, fields in which she has published widely. She lectures to both Medical and Dental Students at the University and is involved in clinical teaching and examining in several local hospitals.


  • PhD
  • PGCE(MedEd)
  • MRCP
  • MBChB (Hons)


Alice graduated from the University of Leicester and has done postgraduate training via the Universities of Dundee and Birmingham, the latter being where she completed a PhD focussed on genetic and environmental influences on COPD and alpha 1 antitrypsin deficiency (AATD). Some of her work in this area resulted in the award of a Young Investigator Prize from the British Lung Foundation in 2009 and the European Lung Science Young Investigator Prize in 2010. The majority of her research has been carried out in Birmingham, although she has strong collaborative links with Harvard University, where she spent a short sabbatical in 2009. She has been a consultant in respiratory medicine at Heart of England NHS Foundation Trust since 2011, and senior clinical lecturer in respiratory medicine at University of Birmingham since 2013. She has published widely in COPD and AATD, and has ongoing research projects funded by the Alpha 1 Foundation, EPSRC and others.

Her current research projects are largely on clinical aspects of COPD and AATD, genetic epidemiology/functional genetics in AATD, and shared pathogenesis of COPD and lung cancer. Her clinical work is mostly at Heart of England NHS Foundation Trust, where she is COPD lead, but she also leads the AATD service at Queen Elizabeth Hospital.


 Degree course/year/module Activity
 Clinical module lead; 6 lectures, 2 small group sessions
 Project lead in lung cancer; 1 lecture, 2 small group sessions
 Clinical component lead; 2 clinics, 2 small group sessions
  •  BDS/3rd/Human Disease
 Module lead (medicine)
 Average 2 students pa for final year dissertation project

Postgraduate supervision

The following is a list of recent or current postgraduate degree supervision. Enquiries from self-funding potential students or those wishing to pursue a Fellowship in my current areas of research interest are welcome by email.

  • MD - Immunomodulatory properties of vitamin D in tuberculosis (write up)
  • MD - Multi-modality classification of AATD related COPD (submitted)
  • MD - Immune activation in AATD associated lung disease (year 3)
  • MD - Ambulatory oxygen therapy in COPD (write up)
  • PhD - Cell specific genomics exploring shared pathogenesis between COPD and lung cancer (year 2)
  • MD - Determinants of type 2 respiratory failure in COPD (write up)
  • PhD - The role of hypoxia in vascular co-morbidity in chronic inflammatory disease (write up)


Clinical and genetic/genomic aspects of AATD

Genetic association work formed the majority of my PhD, but since that time I have had broader clinical research work based around disease progression and clinical phenotyping in AATD. I continue to conduct some work in genetics, which is now more focussed on functional effects of associated SNPs and use of genetic or genomic techniques to personalise therapy.

Systematic reviews in COPD and AATD

I have been involved in 2 major NIHR funded reviews since 2012, both of which have published HTA reports and manuscripts. In addition one of my MD students has led a systematic review of ambulatory oxygen use, which has now been published, and a review of the utility of urinary biomarkers has been undertaken and is under submission. More recently I have gained funding as supervisor and PI respectively for projects which will systematically review diagnostic and therapeutic strategies in AATD. This moves my reviewing closer to my main research area of AATD.

Co-morbidity in COPD

Thus far my primary research in this area has included work on muscle disease and lung cancer. Our group have conducted a randomized, controlled, double-blinded crossover study of ambulatory oxygen against a gas mix equivalent to medical air, with a primary outcome focussed on muscle disease. Parallel animal models run by a PhD student investigated the role of chronic v intermittent hypoxia on muscle and vascular tissue in rats. Lung cancer pathogenesis, particularly shared pathogenesis with COPD, emerged as a theme from my functional genetic work, with both vitamin D binding protein (DBP) and iron regulatory binding protein (IREB2) appearing to play a role; these genes have been the subject of published work and a grant respectively.

Other activities

  • Editorial board member International Journal of Rare Disease and Orphan Drugs – Feb 2016 onwards
  • BTS specialist advisory group on COPD – Oct 2015 onwards
  • European Respiratory Society task force on AATD – March 2015 onwards
  • Editorial board member World Journal of Respirology – 2014 onwards


Ejiofor SI, Bayliss S, Gassamma A & Turner AM (2016) Ambulatory oxygen for exercise induced desaturation and dyspnea in COPD: Systematic review and meta-analysis. Chronic Obstr Pulm Dis (Miami) 3(1):419-34

Green CE, Vayalapra S, Hampson JA, Mukherjee D and Turner AM (2015) PiSZ AATD: pulmonary phenotype and prognosis relative to PiZZ and PiMM COPD. Thorax 70(10):939-45

Turner AM, Lim WS, Rodrigo C, Welham SA and Calvert JM (2015) A care-bundles based approach to improving standards of care in COPD: Results of a national project. Thorax 70(10):992-4

Soriano JB, Lamprecht B, Ramírez AS, Martinez-Camblor P, Kaiser B, Alfageme I, Almagro P, Casanova C, Esteban C, Soler-Cataluña JJ, de Torres JP, Miravitlles M, Celli BR, Marin JM, Puhan MA, Sobradillo P, Lange P, Sternberg AL, Garcia-Aymerich J, Turner AM, Han MK, Langhammer A, Leivseth L, Bakke P, Johannessen A, Roche N and Sin DD (2015) A pooled analysis of 15,632 COPD patients comparing the GOLD 2007 and 2011 staging systems for COPD focused on mortality. Lancet Respir Med 3(6):443-50

Majothi S, Jolly K, Heneghan HR, Price MJ, Riley RD, Turner AM, Bayliss SE, Moore DJ, Singh SJ, Adab P, Fitzmaurice DA and Jordan RE (2015) Supported self-management for patients with COPD who have recently been discharged from hospital: a systematic review.  Int J Chron Obstruct Pulmon Dis 10: 853-67

Gale NK, Jawad M, Dave C and Turner AM (2015) Adapting to domicilliary non-invasive ventilation in chronic obstructure pulmonary disease: a qualitative interview study. Palliative Med 29(3):268-77

Dave C, Turner AM, Thomas A, Beauchamp B, Chakraborty B, Ali A, Mukherjee R and Banerjee D (2014) Utility of respiratory ward-based NIV in aciodotic hypercapnic respiratory failure. Respirology 19:1241-7

Ward H, Turner AM and Stockley RA (2014) Spirometric and gas transfer discordance in AATD; patient characteristics and progression. Chest 145(6):1316-24