Dr Daniel Fulton

Dr Daniel Fulton

Institute of Inflammation and Ageing
Birmingham Fellow

Contact details

Address
Neuroscience and Ophthalmology
Institute of Inflammation and Ageing
College of Medical and Dental Sciences
IBR West
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Daniel Fulton is a Birmingham Fellow in the Neuroscience and Ophthalmology group of the Institute of Inflammation and Ageing. Dr Fulton also holds an honorary appointment at the School of Life Science at the University of Warwick through his role as a Senior Research Fellow in the Science Cities Research Alliance.

Qualifications

  • PhD Neuroscience, 2003
  • BSc Zoology, 1999

Biography

Daniel obtained his PhD in Neuroscience at the University of Sussex in 2003 where his thesis focused on the cellular mechanisms of learning and memory. Following his PhD he pursued postdoctoral research at the University of California Los Angeles (UCLA) where he continued to work on synaptic plasticity and learning and memory. In 2007 he joined the lab of Anthony Campagnoni (also at UCLA) where he begun his work on glial biology. Daniel’s work as a Research Neuroscientist in the Campagnoni lab focused on the physiological properties of oligodendrocytes and the expression of novel myelin proteins within striatal neurons. In 2010 Daniel was awarded a Senior Fellowship with the Science City Research Alliance and in 2011 he obtained a Marie Curie Career Integration Grant. Using these fellowships Daniel returned to the UK to pursue independent work at the University of Warwick investigating the role of neuronal activityin oligodendrocyte development and myelin formation. In July 2013 Daniel moved to the University of Birmingham to take up a Birmingham Fellowship through which he is establishing the Oligodendrocyte and Myelin Research Group within the Institute of Inflammation and Ageing.

Work within the Oligodendrocyte and Myelin Research Group continues to explore activity-dependent mechanisms controlling myelin formation and repair, while also establishing new work to identify novel signalling pathways controlling oligodendrocytes injury, and developing new approaches to image the response of myelin proteins during inflammatory and excitotoxic injury.

Teaching

  • BMedSc
    • Deputy module lead, Neurotrauma: Degeneration and Regeneration
    • Neuroscience 2
    • Integrative Pharmacology

Postgraduate supervision

Daniel is currently supervising 2 PhD students. 

If you are interested in studying with Daniel, please contact him on the contact details above, or for any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk or call +44 (0)121 414 5005.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

Daniel’s research focus is on the development and repair of myelin, the insulating material that ensures efficient nerve impulse conduction and supports the heath of the axon. Damage to myelin through traumatic injury and disease disturbs the coordinated flow of information throughout the CNS, and compromises the health of the underlying axons, leading to impairments in cognition and movement.

The overall aim is to develop a better understanding of the cellular and molecular mechanisms controlling myelin formation, injury, and repair, and identify novel therapeutic targets capable of protecting CNS myelin and promoting its repair.


 [1]Link to lab web page

Other activities

  • Institute Representative for Early Career Researchers
  • Institute lead for Postgraduate Research Plagiarism

Publications

Berry M, Ahmed Z, Morgan-Warren P, Fulton D and Logan A (2016) Prospects for mTOR-mediated functional repair after central nervous system trauma. Neurobiology of Disease 85:99-110

Rassul SM, Neely RK and Fulton D (2015) Live-imaging in the CNS: Insights on oligodendrocytes, myelination, and their responses to inflammation. Neuropharmacology pii: S0028-3908(15)30103-9 [Epub ahead of print]

Fannon J, Tarmier W and Fulton D (2015) Neuronal activity and AMPA-type glutamate receptor activation regulates the morphological development of oligodendrocyte precursor cells. Glia 63(6):1021-35

Leoni G, Rattray M, Fulton D, Rivera A and Butt AM (2014) Immunoablation of cells expressing the NG2 chondroitin sulphate proteoglycan. Journal of Anatomy 224(2):216-27

Fulton D, Paez P, Spreur V, Handley V, Colwell CS, Campagnoni A and Fisher R (2011) Developmental activation of the proteolipid protein promoter transgene in neuronal and oligodendroglial cells of the neostriatum in mice. Developmental Neuroscience 33(2):170-184 *Selected for Editors Choice*

Paez PM, Fulton D, Spreuer V, Handley V and Campagnoni AT (2011) Modulation of canonical transient receptor potential channel 1 in the proliferation of oligodendrocyte precursor cells by the golli products of the myelin basic protein gene. Journal of Neuroscience 31(10):3625-3637

Fulton D, Paez PM, Fisher R, Handley V, Colwell CS and Campagnoni AT (2010) Regulation of L-type Ca++ Currents and process morphology in white matter oligodendrocyte precursor cells by golli-myelin proteins. Glia 58:1292-1303

Paez PM, Fulton D, Spreuer V, Handley V and Campagnoni AT (2009) Multiple kinase pathways regulate voltage-dependent Ca++ influx & migration in oligodendrocyte precursor cells. Journal of Neuroscience 30(18):6422-643

Fulton D1, Paez PM1 and Campagnoni AT (2010) The multiple roles of myelin protein genes during the development of the oligodendrocyte. ASN Neuro 2(1):e00027 1Equal author contribution

Paez PM, Fulton DJ, Spreuer V, Handley V,Campagnoni CW and Campagnoni AT (2009) Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca2+ influx. Journal of Neuroscience 29(20):6663-6676