Professor Mark David Kilby DSc MB BS MD FRCPI FRCOG

Professor Mark David Kilby

Institute of Metabolism and Systems Research
Dame Hilda Lloyd Professor of Fetal Medicine
Lead for the Centre for Women’s & New-born Health

Contact details

Telephone
+44 (0)121 627 2778
Fax
+44 (0) 623 6875
Email
m.d.kilby@bham.ac.uk
Twitter
@Mark_D_Kilby
Address
Academic Department of Obstetrics & Gynaecology
Academic Floor, Third Floor
Birmingham Women’s Foundation Trust
Edgbaston
Birmingham
B15 2TG

Professor Mark Kilby is a clinical scientist working in the field of fetal medicine and therapy. His work focuses upon diverse themes crossing the interface between laboratory-based research and translational clinical trials in valuating diagnostic tests and therapeutic interventions.

The laboratory based work focuses upon aspects of fetal and fetoplacental endocrine/paracrine signalling including the roles of thyroid hormone, glucocorticoids and vitamin D. His group also investigate the cellular immunity (especially T-cell) between the fetoplacental unit and the mother and the control of immunomodulation in human pregnancy. His translational work has focused upon diagnostic accuracy of testing in pregnancy and the evaluation of fetal therapy in singleton and complex multiple pregnancy.

He has over 350 publications and multiple books and review articles. Professor Kilby is a member of the Executive of the Institute of Metabolism and Systems Research. He also leads the Centre for Women’s and Children’s Health and a representative on the Birmingham Health Partners. He has recently given the Mead Johnson Lecturer for the Perinatal Society of the USA and in 2015 received the prestigious Arnaldo Bruno from the Accademia Nazionale dei Lincei in Rome – one of the oldest scientific academia in the world (alma mater to Galileo!) for research and services to Fetal Medicine. He has trained postgraduate academic clinical lecturers and subspecialty trainees from the UK and over the world and leads recruitment for ACF and ACLs in Obstetrics and Gynaecology.

Website : http://www.markkilby.co.uk/
Linkedin : markkilby

 

Qualifications

Professor of Maternal and Fetal Medicine, presently holding the Dame Hilda Lloyd Chair of Fetal Medicine at the University of Birmingham:

  • MB BS. Guy’s Hospital, University of London. 1984.

  • MD. University of Nottingham. 1990.

  • Member of the Royal College of Obstetricians & Gynaecologists (MRCOG). 1991.

  • Fellow of the Royal College of Obstetricians & Gynaecologists (FRCOG). 2007.

  • Doctor of Science (DSc). University of Birmingham. 2011.

  • Fellow of the Royal College of Physicians of Ireland (FRCPI). 2015.

Biography

Professor Kilby was appointed as an Honorary Consultant and Senior Lecturer in Maternal and Fetal Medicine at the University of Birmingham (and Birmingham Women’s NHS Foundation Trust) in March 1996.

After qualification from Guy’s Hospital Medical School in 1984, he performed house jobs at Guy’s Hospital. He was then attached to junior obstetric and gynaecological posts in London, Nottingham and the West Midlands. After a period of research at Nottingham University he was awarded an MD thesis in 1990.

After a sabbatical at the University of Toronto in Canada (Fetal Medicine Centre/Research Institute at the Mount Sinai Hospital), he accredited in general Obstetrics and Gynaecology from the Royal College of Obstetricians and Gynaecologists in 1985. After further specialist training in Birmingham, he obtained his subspecialty accreditation in Maternal and Fetal Medicine from the Royal College of Obstetricians and Gynaecologists in 1996. He is fully registered with the GMC (2926274) and is on the General and Specialist Register for Obstetrics and Gynaecology/Maternal and Fetal Medicine. He underwent revalidation in 2014.

Professor Kilby is one of six accredited consultant subspecialists providing regional and supra-regional care for pregnant women with fetal medicine problems at the West Midlands Fetal Medicine Centre which is situated within the Birmingham Women’s NHS Foundation Trust. The Fetal Medicine Centre at the Birmingham Women’s Hospital NHS Foundation Trust has a catchment area from other referral hospitals within the West Midlands and indeed the whole of the Midlands and the north. Its catchment population is approximately 8 million and it provides a large referral base for an extensive number of local and tertiary referrals.

Professor Kilby’s clinical expertise relates to prenatal diagnosis, the diagnosis of fetal anomalies, conditions requiring fetal therapy including complications of monochorionic twins and intrauterine growth restriction. He has published over 300 peer reviewed original articles on topics related to fetal medicine and the basic science and translational research (from bench to bedside) applied to his subspecialty.

He was the fetal medicine elected representative on the Executive Committee of the British Society of Maternal and Fetal Medicine (BMFMS) between 2000 and 2006 and subsequently until 2009 he served as the clinical scientific adviser on this Executive Committee. In 2011 he was elected as President of the British Society of Maternal and Fetal Medicine and served in this role until 2015. He was elected to the Council of the Royal College of Obstetricians and Gynaecologists as a Members representative and served for the West Midlands between 2002 and 2008. He has subsequently been re-elected as a Fellows representative from 2011 through to 2017. He thus is a full member of the Council of the Royal College of Obstetricians and Gynaecologists.He has served as Chairman on the Research Advisory Committee for the charity Wellbeing of Women (2008 to 2010) and has served on the Clinical Guideline Groups for the National Institute of Clinical Excellence examining routine care for multiple pregnancies (as the Chairperson), interventional therapy in fetal medicine (2006 to present) and intrapartum care of the fetus (2016-).

He was appointed a full Professor (personal Chair) in Maternal and Fetal Medicine to the University of Birmingham in 2003 and then was subsequently appointed as the Dame Hilda Lloyd Chair of Fetal Medicine in 2006 (a position he still holds).Career History2003- Professor of Fetal Medicine, University of Birmingham1999-2003 Clinical Reader, University of Birmingham 1996-1999 Senior Lecturer, University of Birmingham 1994-1996 Clinical Lecturer and Subspecialty trainee in Maternal and Fetal Medicine, University of Birmingham.1992-1994. Clinical Research Fellow (MRC Canada), Samuel Lundfeld Institute, University of Toronto.

Teaching

  • Undergraduate MB ChB (University of Birmingham): First year. Fetal Circulation.

  • Undergraduate MB ChB (University of Birmingham). Human Pregnancy. Small Group teaching.

  • Undergraduate MB ChB (University of Birmingham).Development 1. Obstetrics and Gynaecology.

  • External Examiner of Obstetrics and Gynaecology (MB ChB): Chinese University of Hong Kong.

  • Postgraduate teaching: MRCOG. At RCOG.

  • Postgraduate: RCOG Subspecialty training: Deputy Preceptor at BWH.

  • Responsible for recruitment and Academic supervision for ACL and ACF in Obstetrics & Gynaecology.

Postgraduate supervision

  • Supervision of non-clinical PhD students.

  • Supervision of Clinical PhD students.

  • Supervision of Advanced Specialist training in Maternal and Fetal Medicine.

Research

Research Summary

  • Steroids and the fetoplacental unit: This primarily is focusing upon the actions of vitamin D on both trophoblast and decidua (which contains a heterogeneous mix of immune cells)(uNK, macrophages, dendritic and T-cells) in health and disease (i.e. pre-eclampsia, fetal growth restriction and pregnancy loss).

  • New technologies in prenatal diagnosis and their clinical application: This focuses upon the development and clinical application of non-invasive prenatal testing (NIPT) and new genomic techniques (exome & whole genome sequencing) in prenatal the investigation of fetal anomalies.

  • The evaluation of diagnostic testing and fetal therapy in the management of the ‘sick baby’ in-utero:  The evaluation of diagnostic prenatal ultrasound and tests in utero.  The critical appraisal of evidence and evaluation of fetal therapeutic techniques.

  • The management of monochorionic twins (including twin to twin transfusion syndrome). Investigation the pathophysiology and management of morbid monochorionic twin pregnancies.

  • Maternal immunotolerance and fetal immunology.

Funded by:    

  • Wellcome Trust
  • Action Medical Research
  • Wellbeing of Women
  • Wiseman Trust
  • HTA

Other activities

  • Immediate past-President of the British Maternal & Fetal Medicine Society.

  • Chair of the Wellbeing of Women Scientific Advisory Committee (2006-2011).

  • Chairman of the NICE Clinical Guideline Group for the Management of Multiple Pregnancy (2011).

  • Member of the NICE Guideline Panel for Interventional Medicine (presently).

  • Council Fellows Representative for the Royal Collage of Obstetricians and Gynaecologists (presently).

  • National Complex Obstetric Commissioning Group at NHS E (presently).

  • Member of the NICE Guideline Group for Intrapartum Care (Fetal)(Presently).

  • Chairman of the Subspecialty Training Committee at RCOG.

  • Obstetric Representative on the British Association of Perinatal Medicine.

  • Editor of the Journal of the International Study of Ultrasound in Obstetrics & Gynaecology.

  • He has charitable connections with:

    • Wellbeing of Women (Research into Women’s Health).

    • Richard & Jack Wiseman Trust (Research into complications of Twins).

    • TAMBA

Publications

Selected publications

Over 300 publications that have an h-index of 52; i10 index of 155 and RG score of 47.2.

All cited on pubmed Kilby M (http://www.ncbi.nlm.nih.gov/pubmed?term=kilby%20M).

  1. Morris, RK; Malin GL; Quinlan-Jones E; Middleton LM; 4; Hemming K; Burke D; Daniels JP; Khan KS; Deeks J; Kilby MD. On behalf of the Percutaneous vesicoamniotic shunting in Lower Urinary Tract Obstruction (PLUTO) Collaborative Group.  Percutaneous vesicoamniotic shunting versus conservative management for fetal lower urinary tract obstruction (PLUTO): a randomised trial. Lancet. 2013;382(9903):1496-506

  2. Slaghekke F, Lopriore E, Lewi L, Middeldorp JM, van Zwet EW, Weingertner AS, Klumper FJ, DeKoninck P, Devlieger R, Kilby MD, Rustico M, Deprest J, Favre R, Oepkes D. Fetoscopic Laser Coagulation of the Vascular Equator versus Selective Coagulation for Twin-to-Twin Transfusion Syndrome: a randomised trial. Lancet.2014;29(6):1161-72.

  3. Morris RK, Riley RD, Doug M, Deeks JJ, Kilby MD. Diagnostic accuracy of spot urinary protein and albumin to creatinine ratios for detection of significant proteinuria or adverse pregnancy outcome in patients with suspected pre-eclampsia: systematic review and meta-analysis. BMJ. 2012;345:e4342.

  4. Lissauer D, Piper K, Goodyear O, Kilby MD†, Moss PA† (†Equal senior author). Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity. J Immunol. 2012;189(2):1072-80.

  5. Chan SY, Susarla R, Canovas D, Vasilopoulou E, Ohizua O, McCabe CJ, Hewison M, Kilby MD. Vitamin D promotes human extravillous trophoblast invasion in vitro. Placenta. 2015;36(4):403-9.