Dr Parth Narendran FRCP PhD

Dr Parth Narendran

Institute of Metabolism and Systems Research
Reader in Diabetes Medicine
Honorary Consultant Physician

Contact details

Telephone
+44 (0)121 414 3006
Telephone (2)
+44 (0)121 371 4407
Fax
+44 (0)121 415 8712
Email
p.narendran@bham.ac.uk
Twitter
@parthnarendran
Address
Institute of Metabolism and Systems Research
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
B15 2TT
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Parth is a qualified clinician by background. His research is primarily on type 1 diabetes, in particular on how to preserve the function of insulin producing pancreatic beta cells.

He is currently the co-lead for the West Midlands Clinical Research Network and was previously the diabetes theme lead for the Birmingham and Black Country Clinical Research Network from 2010-14. He leads the Diabetes Research Unit and the Type 1 Diabetes clinical service at the Queen Elizabeth Hospital. He is the author of over 50 peer-reviewed publications including publications that have been cited by international bodies on Type 1 diabetes and its management. He currently sits on the Regional Advisory Committee for the NIHR RfPB programme and was previously on the Research Advisory Board of the Diabetes Research and Wellness Foundation (2009-11). He currently sits on the Profession Conference Organising Committee for Diabetes UK. Parth reviews for all the major national and international diabetes journals and contributes to the NIHR Horizon Scanning Research and Intelligence centre for new therapies.

Qualifications

  • FRCP  Royal College of Physicians, London, UK
  • PhD     Immunology, University of Bristol
  • MRCP Royal College of Physicians, London, UK
  • MBBS  Kings College School of Medicine and Dentistry, University of London
  • BSc     Immunology and Medical Sciences, Kings College, University of London

Biography

Parth undertook his initial immunology research training as part of an intercalated degree. This led to a PhD at the University of Bristol exploring peptide immunotherapy for type 1 diabetes, and subsequently to a post-doctoral fellowship exploring immune tolerance at the Walter and Eliza Hall Institute in Melbourne.

 Parth obtained his basic medical degree in London before completing his higher specialist training in Manchester and Bristol. He took up his current post as an Honorary Consultant Physician at The Queen Elizabeth Hospital, Birmingham in 2005.

Teaching

Lead for MBChB Final Year AIP Medicine

Supervision of academic trainees in diabetes and endocrinology

Lecture: Diabetes Mellitus       CEP     MBChB1

Lecture: Introduction to Diabetes        Endo/Repro     BMedSc3

Lecture: Immunology of Diabetes       Endo/Repro     BMedSc3

Lecture: DKA/Hypoglycaemia AIP      MB ChB

SGT: Diabetes CEP   MPharm1

Lecture: Pharmacology of Diabetes                MPharm1

SGT: Diabetes CEP     MBChB1

Practical: Diabetes      CEP     MBChB1

Postgraduate supervision

Parth has supervised over 10 MD and PhDs on the subject of diabetes and immunology

Research

Parth’s research focuses on type 1 diabetes. His work has extended from bench based investigations, to trials of therapies in individual patients, development of a national biorepository and examination of large datasets. This research has examinined defects in the immune system that predispose to type 1 diabetes, exploring different approaches to preserving the function of insulin producing beta cells, and using ‘big data’ to understand the natural history of type 1 diabetes

Other activities

Parth’s clinical interests focus on type 1 diabetes and he is involved in the structured education programme, the adolescent transition and insulin pump service for University Hospital Birmingham NHS Foundation Trust.

Parth is also the Diabetes theme lead for the Birmingham and Black Country Comprehensive Local Research Network.

Publications

Chimen M, McGettrick HM, Apta B, Kuravi SJ, Yates CM, Kennedy A, Odedra A, Alassiri M, Harrison M, Martin A, Barone F, Nayar S, Hitchcock JR, Cunningham AF, Raza K, Filer A, Copland DA, Dick AD, Robinson J, Kalia N, Walker LS, Buckley CD, Nash GB, Narendran P*, Rainger GE*. (*joint senior and corresponding author).Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. Nature Medicine. 2015 May;21(5):467-75.

Kenefeck R, Wang CJ, Kapadi T, Wardzinski L, Attridge K, Clough LE, Heuts F, Kogimtzis A, Patel S, Rosenthal M, Ono M, Sansom DM, Narendran P, Walker LS. Follicular helper T cell signature in type 1 diabetes. J Clin Invest. 2015 Jan;125(1):292-303.

 Narendran P, Neale AM, Lee BH, Ngui K, Steptoe RJ, Morahan G, Madsen O, Dromey J, Jensen KP, Harrison LC. (2006). Proinsulin is encoded by an RNA splice variant in human blood myeloid cells. Proceedings of the National Academy of Science. 103(44), 16430-16435.

 Nadia Lascar, Amy Kennedy, Beverley Hancock, David Jenkins, Robert C Andrews, Sheila Greenfield, Parth Narendran. Attitudes and barriers to exercise in adults with type 1 diabetes (T1D) and how best to address them: a qualitative study. PLOS ONE. 2014 Sep 19;9(9):e108019. 

 Pang TTL, Chimen M, Goble E, Dixon N, Benbow A, Eldershaw SE, Thompson D, Gough SCL, Narendran P. (2013). Reduced adiponectin receptor expression by monocytes in type 1 diabetes (T1D) results in a pro-inflammatory response to islet antigen. Journal of Clinical Endocrinology and Metabolism. 98(3), 418-428.

 Nirantharakumar K, Hemming K, Narendran P, Marshall T, Coleman JJ. (2013). A Prediction Model for Adverse Outcome in Hospitalized Patients With Diabetes. Diabetes Care. 36 (11), 3566-3572.

 Penaranda C, Kuswanto W, Hofmann J, Kenefeck R, Narendran P, Walker LS, Bluestone JA, Abbas AK, Dooms H. (2012). IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells. Proceedings of the National Academy of Sciences USA. 109(31), 12668-73.

 Parth Narendran. An alternative approach to immunomodulation for type 1 diabetes (T1D): antigen specific immunotherapy in utero. Diabetes. 2015 Oct;64(10):3347-9

 Narendran P, Solomon TP, Kennedy A, Chimen M, Andrews RC. The time has come to test the beta cell preserving effects of exercise in patients with new onset type 1 diabetes. Diabetologia. 2015 Jan;58(1):10-8.

 Kennedy A, Nirantharakumar K, Chimen M, Pang TTL, Hemming K, Andrews RC,  Narendran P. (2013) Does exercise improve glycaemic control in type 1 diabetes?  A systematic review and meta-analysis. PLOS ONE. 8(3), 58861.

 M Chimen, A Kennedy, K Nirantharakumar, TT Pang, R Andrews, P Narendran. (2011) What are the health benefits of physical activity in type 1 diabetes mellitus? A literature review. Diabetologia. 55(3), 542-51.